公开(公告)号：US5903149A

公开(公告)日：1999-05-11

申请号：US843030

申请日：1997-04-11

申请人： Oded Gonen ,  Gadi Goelman ,  John S. Leigh ,  Lizann Bolinger

发明人： Oded Gonen ,  Gadi Goelman ,  John S. Leigh ,  Lizann Bolinger

IPC分类号： G01R33/48 ,  G01R33/485 ,  G01R33/54 ,  G01V3/00

CPC分类号： G01R33/485 ,  G01R33/446 ,  G01R33/4822

摘要： Acquisition of three-dimensional image-guided localized proton spectroscopy (.sup.1 H-MRS) in the human brain is achieved on a standard clinical imager with a hybrid of chemical shift imaging (CSI) and transverse Hadamard spectroscopic imaging (HSI). 16.times.16.times.4 arrays of 3.5 and 1 ml voxels were obtained in 27 minutes. The spatially-selective HSI 90.degree. pulses were incorporated naturally into a PRESS double spin-echo sequence to subdivide the VOI into 4 partitions along its short axis. Two-dimensional CSI is performed along the other long axes. Because the hybrid excites the spins in the entire VOI, a .sqroot.N signal-to-noise-ratio (SNR) gain per given examination time is realized compared to sequentially interleaving N two-dimensional slices. A twofold gain in sensitivity is demonstrated in the brain for N=4.

摘要翻译： 在具有化学位移成像（CSI）和横向Hadamard光谱成像（HSI）的混合物的标准临床成像仪上实现人脑中三维图像引导的局部质子光谱（1H-MRS）的获取。 在27分钟内获得3.5×1×1ml体素的16×16×4阵列。 空间选择性HSI 90°脉冲自然并入PRESS双自旋回波序列，以将VOI沿其短轴细分为4个分区。 沿其他长轴执行二维CSI。 由于混合动力在整个VOI中激发自旋，相比于顺序交错N个二维切片，实现了每个给定检测时间的2ROOT + E，rad N + EE信噪比（SNR）增益。 N = 4时脑中的灵敏度提高了两倍。

公开(公告)号：US20050099178A1

公开(公告)日：2005-05-12

申请号：US10916640

申请日：2004-08-12

申请人： Scott King ,  Lizann Bolinger

发明人： Scott King ,  Lizann Bolinger

IPC分类号： G01R33/561 ,  G01V3/00

CPC分类号： G01R33/5611

摘要： In a method of spatial encoding in magnetic resonance experiments, encoding kernels are imposed into the magnetization signal during the excitation or re-focussing process using a transmit array coil. Separate transmit array coil elements are provided so that in a particular phase encode direction, z in this case, they can be driven to produce partially orthogonal B1 fields, Tt(r), that exhibit a Fourier phase distribution given by Tt(r)=T0ei(ktTz)=T0ei(tΔkzz). The NMR signal, Sm(kn), received by a coil array element m of the M receive coils, during application of a pulse sequence for the n-th phase encoding step in k-space is then given by Sm(kn)=∫drρ′(r)ei(kn·r)Cm(r) such that ρ′(r)=ρ(r)Tt(r)=ρ(r)T0ei(tΔkzz) where kn is the nth spatial encoding k-space trajectory for the spatial dimension r, Cm(r) is the receive coil sensitivity, and ρ′(r) represents the magnetization spatial distribution arising from the spin density spatial distribution ρ(r), the pulse sequence and the transmit array excitation/re-focussing phase profile. It is clear that using an appropriately driven transmit array capable of producing the tth phase encode term, gradient phase encode steps may be eliminated.

公开(公告)号：US07141973B2

公开(公告)日：2006-11-28

申请号：US10916640

申请日：2004-08-12

申请人： Scott King ,  Lizann Bolinger

发明人： Scott King ,  Lizann Bolinger

IPC分类号： G01V3/00

CPC分类号： G01R33/5611

摘要： In a method of spatial encoding in magnetic resonance experiments, encoding kernels are imposed into the magnetization signal during the excitation or re-focussing process using a transmit array coil. Separate transmit array coil elements are provided so that in a particular phase encode direction, z in this case, they can be driven to produce partially orthogonal B1 fields, Tt(r), that exhibit a Fourier phase distribution given by Tt(r)=T0ei(ktTz)=T0ei(tΔkzz). The NMR signal, Sm(kn), received by a coil array element m of the M receive coils, during application of a pulse sequence for the n-th phase encoding step in k-space is then given by Sm(kn)=∫drρ′(r)ei(kn·r)Cm(r) such that ρ′(r)=ρ(r)Tt(r)=ρ(r)T0ei(tΔkzz) where kn is the nth spatial encoding k-space trajectory for the spatial dimension r, Cm(r) is the receive coil sensitivity, and ρ′(r) represents the magnetization spatial distribution arising from the spin density spatial distribution ρ(r), the pulse sequence and the transmit array excitation/re-focussing phase profile. It is clear that using an appropriately driven transmit array capable of producing the tth phase encode term, gradient phase encode steps may be eliminated.