公开(公告)号：US20120329877A1

公开(公告)日：2012-12-27

申请号：US13489745

申请日：2012-06-06

申请人： Onur Atasoylu ,  Carlo Ballatore ,  Kurt R. Brunden ,  Longchun Huang ,  Donna M. Huryn ,  Michael James ,  Virginia M.Y. Lee ,  Francesco Piscitelli ,  Amos B. Smith, III ,  James Soper ,  John Q. Trojanowski

发明人： Onur Atasoylu ,  Carlo Ballatore ,  Kurt R. Brunden ,  Longchun Huang ,  Donna M. Huryn ,  Michael James ,  Virginia M.Y. Lee ,  Francesco Piscitelli ,  Amos B. Smith, III ,  James Soper ,  John Q. Trojanowski

IPC分类号： C07C311/19 ,  A61P11/00 ,  A61P3/10 ,  A61P11/06 ,  A61K31/18 ,  A61P25/28

CPC分类号： C07C311/17 ,  A61K31/18 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07D257/04

摘要： The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6 alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and X is O or N; as well as tautomers and pharmaceutically acceptable salt forms thereof. Uses of these compounds are also described.

摘要翻译： 本发明涉及式I化合物：其中A是n是0,1或2; m为0或1; R 1是H或C 1-6烷基，R 2是H，C 1-6烷基，取代或未取代的芳基或取代或未取代的杂芳基; X为O或N; 以及互变异构体及其药学上可接受的盐形式。 还描述了这些化合物的用途。