公开(公告)号：US20120308613A1

公开(公告)日：2012-12-06

申请号：US13455277

申请日：2012-04-25

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

IPC分类号： A61K9/72 ,  A61K31/58 ,  A61K31/137 ,  A61K47/26 ,  A61P11/00

CPC分类号： A61K9/0075 ,  A61K9/0078 ,  A61K9/145 ,  A61K31/167 ,  A61K31/573 ,  A61K31/58

摘要： A formulation for an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; active particles; and additive material to which is able to promote release of the active particles from the carrier particles on actuation of the inhaler device. The formulation has excellent flowability even at relatively high fine particle contents.

摘要翻译： 用于吸入器装置的制剂包括直径至少为50μm且质量中值直径至少为175μm的载体颗粒; 活性颗粒; 以及添加剂材料，其能够在致动吸入器装置时促进活性颗粒从载体颗粒中的释放。 该制剂即使在相对高的细颗粒含量下也具有优异的流动性。

公开(公告)号：US07541022B2

公开(公告)日：2009-06-02

申请号：US10257886

申请日：2001-04-17

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

IPC分类号： A61K9/14 ,  A61K9/16

CPC分类号： A61K9/16 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1682 ,  A61K31/167 ,  A61K31/58

摘要： A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

摘要翻译： 用于干粉吸入器的粉末包括：i）由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的分数n; ii）一部分粗颗粒; 和iii）至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地，本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂，可以以简单的方式产生，物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。