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公开(公告)号：US20120071449A1
公开(公告)日：2012-03-22
申请号：US13202081
申请日：2010-02-18
IPC分类号： A61K31/58 , A61K31/573 , A61K31/4704 , A61P9/00 , A61P11/06 , A61P11/00 , A61P37/08 , A61P31/00 , A61K31/137 , A61K31/439
CPC分类号： A61K9/0075 , A61K45/06 , Y10T428/2982
摘要： The present invention relates to a pharmaceutical composition for inhalation. The invention is further directed to a method for setting the performance characteristics of such a pharmaceutical composition and the use of such a composition in the treatment of asthma, COPD, allergies, infectious diseases and diseases of the cardiovascular system.
摘要翻译： 本发明涉及用于吸入的药物组合物。 本发明还涉及一种用于设定这种药物组合物的性能特征的方法以及这种组合物在治疗哮喘，COPD，过敏，感染性疾病和心血管系统疾病中的用途。
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2.发明授权Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets 有权用于干粉吸入器的药物制剂，以硬丸的形式公开(公告)号：US07223748B2
公开(公告)日：2007-05-29
申请号：US11073625
申请日：2005-03-08
申请人： John Nicholas Staniforth , David Alexander Vodden Morton , Rajbir Gill , Gaetano Brambilla , Rossella Musa , Lorenzo Ferrarini
发明人： John Nicholas Staniforth , David Alexander Vodden Morton , Rajbir Gill , Gaetano Brambilla , Rossella Musa , Lorenzo Ferrarini
IPC分类号： A61K31/58 , A61K31/47 , A61K31/135 , A61K9/14 , A61K9/50
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/145 , A61K31/167 , A61K31/573 , A61K31/58
摘要： The invention provides a formulation to be administered as a dry powder for inhalation suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from a pulmonary disease such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation freely flowable, which can be produced in a simple way, is physically and chemically stable and capable of delivering both accurate doses and high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.
摘要翻译： 本发明提供了一种作为吸入干燥粉末施用的制剂，其适用于将活性成分有效递送到患有肺部疾病如哮喘的患者的低呼吸道中。 特别地，本发明提供了作为可自由流动的吸入的干燥粉末施用的制剂，其可以以简单的方式产生，在物理和化学上是稳定的，并且能够递送精确剂量和低强度活性成分的高细颗粒级分 通过使用高电阻或中等电阻器件。
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公开(公告)号：US09351928B2
公开(公告)日：2016-05-31
申请号：US12782283
申请日：2010-05-18
IPC分类号： A61K9/16 , A61K9/14 , A61K31/167 , A61K31/58 , A61K9/00 , A61K31/573
CPC分类号： A61K9/1688 , A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K31/137 , A61K31/167 , A61K31/4468 , A61K31/4985 , A61K31/573 , A61K31/58 , Y10S514/958
摘要： A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.
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公开(公告)号：US20120308613A1
公开(公告)日：2012-12-06
申请号：US13455277
申请日：2012-04-25
申请人： John Nicholas Staniforth , David Alexander Vodden Morton , Rajbir Gill , Gaetano Brambilla , Rossella Musa , Lorenzno Ferrarini
发明人： John Nicholas Staniforth , David Alexander Vodden Morton , Rajbir Gill , Gaetano Brambilla , Rossella Musa , Lorenzno Ferrarini
IPC分类号： A61K9/72 , A61K31/58 , A61K31/137 , A61K47/26 , A61P11/00
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/145 , A61K31/167 , A61K31/573 , A61K31/58
摘要： A formulation for an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; active particles; and additive material to which is able to promote release of the active particles from the carrier particles on actuation of the inhaler device. The formulation has excellent flowability even at relatively high fine particle contents.
摘要翻译： 用于吸入器装置的制剂包括直径至少为50μm且质量中值直径至少为175μm的载体颗粒; 活性颗粒; 以及添加剂材料，其能够在致动吸入器装置时促进活性颗粒从载体颗粒中的释放。 该制剂即使在相对高的细颗粒含量下也具有优异的流动性。
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公开(公告)号：US20100285142A1
公开(公告)日：2010-11-11
申请号：US12782283
申请日：2010-05-18
CPC分类号： A61K9/1688 , A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K31/137 , A61K31/167 , A61K31/4468 , A61K31/4985 , A61K31/573 , A61K31/58 , Y10S514/958
摘要： A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.
摘要翻译： 用于制备用于药物组合物的复合赋形剂颗粒的方法包括研磨步骤，其中在添加剂材料存在下研磨赋形剂材料的颗粒。 产品颗粒尺寸小，铣削时间和能量输入相对较低。 复合颗粒适用于可吸入药物组合物。
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公开(公告)号：US20100209358A1
公开(公告)日：2010-08-19
申请号：US12767530
申请日：2010-04-26
IPC分类号： A61K9/12 , A61K9/14 , A61K31/225
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
摘要翻译： 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法，所述方法包括研磨步骤，其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。
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7.发明申请Composition, device, and method for treating sexual dysfunction via inhalation 审中-公开通过吸入治疗性功能障碍的成分，装置和方法公开(公告)号：US20100018523A1
公开(公告)日：2010-01-28
申请号：US12459686
申请日：2009-07-06
申请人： John Nicolas Staniforth , David Alexander Vodden Morton , Michael Tobyn , Stephen Eason , Quentin Harmer , David Ganderton
发明人： John Nicolas Staniforth , David Alexander Vodden Morton , Michael Tobyn , Stephen Eason , Quentin Harmer , David Ganderton
CPC分类号： A61K9/0075 , A61K9/14 , A61K9/145 , A61K31/4745
摘要： A composition, device, and method for treating sexual dysfunction via inhalation is provided which comprises inhaling a dose of a powder composition, the powder composition comprising apomorphine or pharmaceutically acceptable salts thereof. Preferably, the powder composition further includes a carrier material, the carrier material has an average particle size of from about 40 to about 70 microns, and at least 90 percent of said apomorphine has a particle size of 5 microns or less.
摘要翻译： 提供了通过吸入治疗性功能障碍的组合物，装置和方法，其包括吸入一定剂量的粉末组合物，所述粉末组合物包含阿扑吗啡或其药学上可接受的盐。 优选地，粉末组合物还包括载体材料，载体材料具有约40至约70微米的平均粒度，并且至少90％的所述阿扑吗啡具有5微米或更小的粒度。
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公开(公告)号：US08840930B2
公开(公告)日：2014-09-23
申请号：US13202081
申请日：2010-02-18
CPC分类号： A61K9/0075 , A61K45/06 , Y10T428/2982
摘要： The present invention relates to a pharmaceutical composition for inhalation. The invention is further directed to a method for setting the performance characteristics of such a pharmaceutical composition and the use of such a composition in the treatment of asthma, COPD, allergies, infectious diseases and diseases of the cardiovascular system.
摘要翻译： 本发明涉及用于吸入的药物组合物。 本发明还涉及一种用于设定这种药物组合物的性能特征的方法以及这种组合物在治疗哮喘，COPD，过敏，感染性疾病和心血管系统疾病中的用途。
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公开(公告)号：US20120027863A1
公开(公告)日：2012-02-02
申请号：US13269025
申请日：2011-10-07
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for Pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译： 本发明提供了用于肺部给药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。 本发明还提供了制造微粒的方法。
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公开(公告)号：US08101160B2
公开(公告)日：2012-01-24
申请号：US10257883
申请日：2001-04-17
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/145 , A61K31/167 , A61K31/573 , A61K31/58
摘要： A formulation for use in an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 μm; and active particles. The formulation has excellent flowability even at relatively high contents of fine particles.
摘要翻译： 用于吸入器装置的制剂包括直径至少为50μm，质量中值直径至少为175μm的载体颗粒; 具有质量中值空气动力学直径不超过20μm的赋形剂材料的细颗粒; 和活性颗粒。 该制剂即使在相对高含量的细颗粒下也具有优异的流动性。
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