公开(公告)号：US07276632B2

公开(公告)日：2007-10-02

申请号：US10581033

申请日：2004-12-14

申请人： Rainer Noack ,  Lothar Rüb ,  Clemens Palm

发明人： Rainer Noack ,  Lothar Rüb ,  Clemens Palm

IPC分类号： C07C45/72

CPC分类号： C07C47/24 ,  C07C45/74

摘要： The invention relates to a method for producing 2,3-cis-substituted 2-aryl propenals by condensing a 2-aryl acetaldehyde I with a non-enolizable aldehyde compound II in the presence of a base. The inventive method is characterized in that the reaction is carried out in a solvent mixture comprising at least one water-miscible organic solvent and water at a volume ratio Vsolvent:Vwater ranging between 10:1 and 0.5:1.

摘要翻译： 本发明涉及通过在碱存在下将2-芳基乙醛I与不可烯化醛化合物II缩合来制备2,3-顺式取代的2-芳基丙烯醛的方法。 本发明的方法的特征在于反应在包含至少一种与水可混溶的有机溶剂和水的溶剂混合物中进行，体积比为V < 范围在10：1和0.5：1之间。

公开(公告)号：US07105662B2

公开(公告)日：2006-09-12

申请号：US10471550

申请日：2002-03-15

申请人： Michael Henningsen ,  Andreas Kusche ,  Michael Hüllmann ,  Lothar Rüb ,  Stefan Käshammer ,  Till Gerlach

发明人： Michael Henningsen ,  Andreas Kusche ,  Michael Hüllmann ,  Lothar Rüb ,  Stefan Käshammer ,  Till Gerlach

IPC分类号： C07D265/30

CPC分类号： C07D295/027 ,  C07D295/023 ,  C07D295/03

摘要： The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R1 and R2, independently of one another, are hydrogen, alkyl or cycloalkyl, or R1 and R2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R3 and R4, independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R1 and R2 have the meanings given above, with at least one morpholine of the formula III in which R3 and R4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

摘要翻译： 本发明涉及一种其中R 1和R 2彼此独立地制备式I的N-取代的2,6-二硫代吗啉的方法， 是氢，烷基或环烷基，或R 1和R 2与它们所键合的碳原子一起为5至14元碳环， 通过使至少一种式II的羰基化合物与其中R 1，R 2，R 3和R 4彼此独立地是烷基或环烷基， 和R 2具有上面给出的含义，其中至少一个式III的吗啉其中R 3和R 4具有给定的含义 在氢气和至少一种含金属的催化剂的存在下，催化剂的活性组分基本上由铂族金属组成。