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公开(公告)号：US20110130572A1
公开(公告)日：2011-06-02
申请号：US12788014
申请日：2010-05-26
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译： 本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫 疾病。
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公开(公告)号：US07745643B2
公开(公告)日：2010-06-29
申请号：US12252278
申请日：2008-10-15
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译： 本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫 疾病。
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3.发明授权Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same 有权合成和分离N-（溴乙酰基）-3,3-二硝基氮杂环丁烷的方法及其组合物公开(公告)号：US08471041B2
公开(公告)日：2013-06-25
申请号：US12702782
申请日：2010-02-09
IPC分类号： C07D205/04
CPC分类号： C07D205/04
摘要： A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ and a salt of DNAZ. Water and a solvent are added to the mixture to form an organic phase comprising the ABDNAZ and an aqueous phase comprising the salt of DNAZ. The organic phase and the aqueous phase are separated to produce an ABDNAZ/solvent solution comprising the ABDNAZ and the aqueous phase comprising the salt of DNAZ. A nonsolvent is added to the ABDNAZ/solvent solution to produce an ABDNAZ/solvent/nonsolvent mixture. The ABDNAZ is subsequently recovered. A composition comprising ABDNAZ is also disclosed.
摘要翻译： 通过使DNAZ与溴乙酰溴和三氟化硼乙醚合物反应合成N-（溴乙酰基）-3,3-二硝基氮杂环丁烷（ABDNAZ）并产生包含ABDNAZ和DNAZ盐的混合物的方法。 向混合物中加入水和溶剂以形成包含ABDNAZ的有机相和包含DNAZ盐的水相。 分离有机相和水相以产生包含ABDNAZ和包含DNAZ盐的水相的ABDNAZ /溶剂溶液。 向ABDNAZ /溶剂溶液中加入非溶剂以产生ABDNAZ /溶剂/非溶剂混合物。 随后回收ABDNAZ。 还公开了包含ABDNAZ的组合物。
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4.发明申请METHODS OF SYNTHESIZING AND ISOLATING N-(BROMOACETYL)-3,3-DINITROAZETIDINE AND A COMPOSITION INCLUDING THE SAME 有权合成和分离N-（溴代乙酰基）-3,3-哌啶酮的方法和包括其的组合物公开(公告)号：US20110195947A1
公开(公告)日：2011-08-11
申请号：US12702782
申请日：2010-02-09
IPC分类号： A61K31/397 , C07D205/04 , A61P35/00
CPC分类号： C07D205/04
摘要： A method of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine (ABDNAZ) by reacting DNAZ with bromoacetyl bromide and boron trifluoride etherate to produce a mixture comprising ABDNAZ and a salt of DNAZ. Water and a solvent are added to the mixture to form an organic phase comprising the ABDNAZ and an aqueous phase comprising the salt of DNAZ. The organic phase and the aqueous phase are separated to produce an ABDNAZ/solvent solution comprising the ABDNAZ and the aqueous phase comprising the salt of DNAZ. A nonsolvent is added to the ABDNAZ/solvent solution to produce an ABDNAZ/solvent/nonsolvent mixture. The ABDNAZ is subsequently recovered. A composition comprising ABDNAZ is also disclosed.
摘要翻译： 通过使DNAZ与溴乙酰溴和三氟化硼乙醚合物反应合成N-（溴乙酰基）-3,3-二硝基氮杂环丁烷（ABDNAZ）并产生包含ABDNAZ和DNAZ盐的混合物的方法。 向混合物中加入水和溶剂以形成包含ABDNAZ的有机相和包含DNAZ盐的水相。 分离有机相和水相以产生包含ABDNAZ和包含DNAZ盐的水相的ABDNAZ /溶剂溶液。 向ABDNAZ /溶剂溶液中加入非溶剂以产生ABDNAZ /溶剂/非溶剂混合物。 随后回收ABDNAZ。 还公开了包含ABDNAZ的组合物。
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公开(公告)号：US20090093644A1
公开(公告)日：2009-04-09
申请号：US12252278
申请日：2008-10-15
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译： 本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫 疾病。
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6.发明授权Energetic plasticizer, and explosive and propellant composition containing same 失效能量增塑剂，含有其的爆炸性和推进剂组合物公开(公告)号：US06425966B1
公开(公告)日：2002-07-30
申请号：US09661557
申请日：2000-09-14
IPC分类号： C06B4510
CPC分类号： C06B45/105
摘要： 2,2-dinitro-1,3-propanediol-diformate is a novel low sensitivity, energetic plasticizer that is useful in explosive and propellant compositions. 2,2-dinitro-1,3-propanediol-diformate can be made by reacting 2,2-dinitro-1,3-propane diol with acetic formic anhydride in the presence of pyridine and at least one solvent.
摘要翻译： 2,2-二硝基-1,3-丙二醇二甲酸酯是一种新颖的低灵敏度，高能增塑剂，可用于爆炸和推进剂组合物。 2,2-二硝基-1,3-丙二醇二甲酸酯可以通过使2,2-二硝基-1,3-丙二醇与乙酸甲酸酐在吡啶和至少一种溶剂的存在下反应来制备。
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7.发明授权Polymerization of poly(glycidyl nitrate) from high purity glycidyl nitrate synthesized from glycerol 有权从甘油合成的高纯度缩水甘油硝酸酯聚合聚（缩水甘油基硝酸盐）公开(公告)号：US06362311B1
公开(公告)日：2002-03-26
申请号：US09688819
申请日：2000-10-17
IPC分类号： C08G5968
CPC分类号： C08G65/22 , C06B45/105
摘要： Glycerol is nitrated with at least one nitrating source in a solvent to form a nitrated glycerol solution containing dinitroglycerin. The nitrated glycerol solution is treated with at least one cyclizing agent to convert the dinitroglycerin into glycidyl nitrate, which is polymerized into poly(glycidyl nitrate) (PGN). Distillation or other vaporization techniques are not required to remove nitroglycerin from the glycidyl nitrate prior to polymerization of the glycidyl nitrate. Rather, the nitroglycerin can be carried along with the dinitroglycerin during polymerization. As a consequence, the glycidyl nitrate is not exposed to elevated temperatures sufficient to cause accidental explosion or deflagration of the nitrate ester. Still more preferably, the glycidyl nitrate is not heated above room temperature at any time prior to polymerization. Moreover, given the high energy performance of nitroglycerin, the nitroglycerin can optionally be retained with the PGN, i.e., not washed out, for subsequent processing and end use.
摘要翻译： 甘油在溶剂中用至少一个硝化源进行硝化，以形成含有二硝基甘油的硝化甘油溶液。 硝化甘油溶液用至少一种环化剂处理以将二硝基甘油转化为缩水甘油基硝酸酯，其被聚合成聚（硝酸缩水甘油酯）（PGN）。 在硝酸缩水甘油酯聚合之前，不需要蒸馏或其他蒸发技术从硝酸甘油酯中除去硝酸甘油。 相反，在聚合过程中硝酸甘油可以与二硝基甘油一起携带。 因此，硝酸缩水甘油酯不会暴露于足以引起硝酸酯意外爆炸或爆燃的升高温度。 还更优选地，在聚合之前的任何时间，硝酸缩水甘油酯不被加热到室温以上。 此外，考虑到硝酸甘油的高能量性能，硝酸甘油可以任选地与PGN保留，即不被洗涤，以用于后续的加工和最终用途。
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公开(公告)号：US08178698B2
公开(公告)日：2012-05-15
申请号：US12788014
申请日：2010-05-26
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译： 本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫 疾病。
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公开(公告)号：US06416601B1
公开(公告)日：2002-07-09
申请号：US09784475
申请日：2001-02-15
IPC分类号： C06B2100
CPC分类号： C07D257/02 , Y10S149/124
摘要： Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, is added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.
摘要翻译： 硝胺是在高能材料中发现的更昂贵和经常更丰富的成分之一，例如固体火箭发动机推进剂，爆炸物和烟火。 通过用含有不超过55重量％的硝酸水溶液的硝酸水溶液处理镀铝的能量材料，其中硝酸水溶液与高分子材料的重量比为约4:1至约6:1，常规镀铝能量 材料被消化成溶液，除了硝酸铵基本上不溶于硝酸水溶液中，并且可以回收而不需要硝酸盐的重结晶。 加入硝酸以外的无机酸，优选盐酸，以提高铝的消化速度。 高能材料的处理可以在没有挥发性有机溶剂的情况下进行，从而避免使用挥发性有机溶剂引起的生态，成本和安全问题。
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10.发明授权
公开(公告)号：US5523517A
公开(公告)日：1996-06-04
申请号：US386152
申请日：1995-02-09
IPC分类号： A62D3/00 , A62D3/30 , A62D3/37 , A62D101/06 , A62D101/26 , A62D101/28 , B01D53/04
CPC分类号： A62D3/30 , A62D2101/06 , Y02C20/10 , Y10S149/124
摘要： A process of degrading nitramines by mixing the nitramine with an aqueous dispersion of metal powders and by heating the mixture is disclosed. HMX and RDX are typical nitramines which are degraded according to the present invention. Metal powders which have been successfully used include aluminum and zinc. The weight ratio of nitramine to metal powder is less than about 17:1. The aqueous mixture of nitramine and metal powder is preferably heated to a temperature greater than about 50.degree. C. and up to the boiling point of the mixture. Best results have been obtained when an aqueous base is used in connection with the metal powder. Aqueous ammonia and dilute hydroxide salt solutions are currently preferred aqueous base solutions.
摘要翻译： 公开了通过将硝胺与金属粉末的水分散体混合并通过加热混合物来降解硝胺的方法。 HMX和RDX是根据本发明降解的典型的硝胺。 成功使用的金属粉末包括铝和锌。 硝胺与金属粉末的重量比小于约17：1。 优选将硝胺和金属粉末的水性混合物加热至大于约50℃，直到混合物的沸点。 当与金属粉末结合使用水性碱时，已经获得了最佳结果。 氨水和稀氢氧化物盐溶液目前是优选的碱性溶液。
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