公开(公告)号：US4758561A

公开(公告)日：1988-07-19

申请号：US757499

申请日：1985-07-22

申请人： Guillaume Le Baut ,  Louis Sparfel ,  Marie-Helene Creuzet ,  Claude Feniou ,  Henri Pontagnier ,  Gisele Prat

发明人： Guillaume Le Baut ,  Louis Sparfel ,  Marie-Helene Creuzet ,  Claude Feniou ,  Henri Pontagnier ,  Gisele Prat

IPC分类号： C07D295/10 ,  A61K31/13 ,  A61K31/135 ,  A61K31/34 ,  A61K31/341 ,  A61K31/445 ,  A61K31/55 ,  A61P7/10 ,  A61P11/08 ,  A61P25/24 ,  A61P25/26 ,  C07D307/52 ,  A61K31/40

CPC分类号： A61K31/135

摘要： The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.

摘要翻译： 本发明涉及药物组合物，其包含有效量的具有结构式（I）的产物，其中R 1是氢原子或低级烷基如甲基或乙基，R 2是直链或支链环丙基甲基，2-呋喃基 甲基，苄基，苯基或C1至C4的低级烷基如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基; NR1R2基团也可以表示氮杂环化合物N（CH 2）n，其中n可以是4和6之间的任何值。由于它们具有抗炎，利尿，支气管扩张，抗胆碱能，抗痉挛性 和抗抑郁药。

公开(公告)号：US4757067A

公开(公告)日：1988-07-12

申请号：US005657

申请日：1987-01-21

申请人： Guillaume Le Baut ,  Louis Sparfel ,  Marie-Helene Creuzet ,  Claude Feniou ,  Henri Pontagnier ,  Gisele Prat

发明人： Guillaume Le Baut ,  Louis Sparfel ,  Marie-Helene Creuzet ,  Claude Feniou ,  Henri Pontagnier ,  Gisele Prat

IPC分类号： C07D295/10 ,  A61K31/13 ,  A61K31/135 ,  A61K31/34 ,  A61K31/341 ,  A61K31/445 ,  A61K31/55 ,  A61P7/10 ,  A61P11/08 ,  A61P25/24 ,  A61P25/26 ,  C07D307/52

CPC分类号： A61K31/135

摘要： The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.

摘要翻译： 本发明涉及药物组合物，其包含有效量的结构式（I）的产物，其中R 1是氢原子或低级烷基如甲基或乙基，R 2是直链或支链环丙基甲基，2-呋喃基 甲基，苄基，苯基或C1至C4的低级烷基如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基; NR1R2基团也可以表示氮杂环化合物N（CH 2）n，其中n可以是4和6之间的任何值。由于它们具有抗炎，利尿，支气管扩张，抗胆碱能，抗痉挛性 和抗抑郁药。