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1.发明申请公开(公告)号：US20050123178A1
公开(公告)日：2005-06-09
申请号：US10495407
申请日：2002-11-05
申请人： Pierre Teppaz , Salah Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
发明人： Pierre Teppaz , Salah Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/055 , A61B8/587 , B33Y80/00 , G01R33/58 , G09B23/286
摘要： A multimodality imaging phantom is disclosed which is useful for calibrating devices for imaging vascular conduits. The phantom is compatible with X-ray, ultrasound and magnetic resonance imaging techniques. It allows testing, calibration, and inter-modality comparative study of imaging devices, in static or dynamic flow conditions. It also provides a geometric reference for evaluation of accuracy of imaging devices. The tissue-mimicking material is preferably an agar-based solidified gel. A vessel of known desired geometry runs throughout the gel and is connected to an inlet and outlet at its extremities for generating a flow circulation in the vessel. Said phantom also contains fiducial markers detectable in the above-mentioned modalities. The markers are preferably made of glass and are embedded in a layer of agar gel containing a fat component. The markers are implanted at precise known locations to allow identification and orientation of plane views, and they can be used for calibration, resealing and fusion of 3D images obtained from different modalities, and 3D image reconstruction from angiographic plane views. Also disclosed is a process for manufacturing said phantom.
摘要翻译： 公开了一种多模态成像体模，其用于校准用于成像血管导管的装置。 幻影与X射线，超声和磁共振成像技术兼容。 它允许在静态或动态流动条件下的成像装置的测试，校准和模式间比较研究。 它还提供了用于评估成像设备精度的几何参考。 组织模拟材料优选为基于琼脂的固化凝胶。 具有已知所需几何形状的容器在整个凝胶中运行，并连接到其末端的入口和出口，以在容器中产生流动循环。 所述幻影还包含在上述方式中可检测的基准标记。 标记物优选由玻璃制成并嵌入含有脂肪成分的琼脂凝胶层中。 标记植入在精确的已知位置以允许平面视图的识别和取向，并且它们可用于从不同模态获得的3D图像的校准，重新密封和融合以及来自血管造影平面视图的3D图像重建。 还公开了用于制造所述体模的方法。
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2.发明授权Method and apparatus for estimating systolic and mean pulmonary artery pressures of a patient 有权用于估计患者的收缩期和平均肺动脉压的方法和装置公开(公告)号：US06368283B1
公开(公告)日：2002-04-09
申请号：US09658631
申请日：2000-09-08
IPC分类号： A61B500
CPC分类号： A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0245 , A61B5/7257 , A61B5/7275 , A61B7/04
摘要： The method of estimating systolic and mean pulmonary artery pressures of a patient, comprising the steps of (a) producing an electric signal xs(t) representative of heart sounds of the patient; (b) extracting second heart sound S2(t) from the signal produced in step (a); (c) extracting pulmonary and aortic components P2(t) and A2(t) from S2(t); (d) extracting a signal representative of mean cardiac interval; (e) correlating the pulmonary and aortic components P2(t) and A2(t) to obtain a cross correlation function; (f) measuring a splitting interval of the cross correlation function obtained in step (e); (g) producing a normalized splitting interval; and (h) estimating the systolic and mean pulmonary artery pressures by means of predetermined regressive functions. The present invention also relates to an apparatus for estimating systolic and mean pulmonary artery pressures of a patient.
摘要翻译： 估计患者的收缩期和平均肺动脉压的方法，包括以下步骤：（a）产生代表患者心音的电信号xs（t）; （b）从步骤（a）中产生的信号中提取第二心音S2（t）; （c）从S2（t）提取肺和主动脉成分P2（t）和A2（t）; （d）提取代表平均心脏间隔的信号; （e）将肺和主动脉成分P2（t）和A2（t）相关联以获得互相关函数; （f）测量步骤（e）中获得的互相关函数的分割间隔; （g）产生归一化分割间隔; 和（h）通过预定的回归函数估计收缩期和平均肺动脉压。 本发明还涉及一种用于估计患者的收缩期和平均肺动脉压的装置。
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公开(公告)号：US5602924A
公开(公告)日：1997-02-11
申请号：US164382
申请日：1993-12-09
CPC分类号： A61B7/005
摘要： The electronic stethoscope is designed to minimize the influence of the various types of noise while optimizing auscultation of the sounds of interest, and to enable a cardiologist to auscultate mechanical heart valves. It comprises a probe for sensing sounds of interest produced within a patient's body and for converting these sounds to an electric signal, and an audio amplifier and earphones for reproducing the sounds of interest in response to this electric signal. The stethoscope comprises (a) a first filter unit having a frequency response that optimizes filtering of the tremor and passing of the low frequency sound components of interest in the range including the frequencies lower than 75 Hz, (b) a second filter unit having a frequency response that optimizes both attenuation of the ambient noise and passing of the sound components of interest in the range 110-1300 Hz, taking into consideration the variation of sensitivity of the human ear in function of frequency, (c) a third filter unit for passing the sounds of mechanical heart valves, and (d) a level detector detecting the amplitude level of the electric signal to activate a pulse generator of which the pulses are applied to the audio amplifier for momentarily and repeatedly disabling this audio amplifier when the detected amplitude level is higher than a predetermined amplitude level threshold.
摘要翻译： 电子听诊器旨在最大程度地减少各种类型的噪音的影响，同时优化感兴趣的声音的听诊，并使心脏科医生能够听取机械心脏瓣膜。 它包括用于感测在患者体内产生的感兴趣的声音并用于将这些声音转换成电信号的探针，以及响应于该电信号再现感兴趣的声音的音频放大器和耳机。 听诊器包括（a）具有频率响应的第一滤波器单元，其优化在包括低于75Hz的频率的范围内的震颤和感兴趣的低频声音分量的通过，（b）第二滤波器单元，具有 频率响应，考虑到人耳在频率函数上的灵敏度的变化，优化环境噪声的衰减和感兴趣的声音分量在110-1300Hz的范围内，（c）第三滤波器单元，用于 传递机械心脏瓣膜的声音，以及（d）检测电信号的振幅电平的电平检测器，激活脉冲发生器，脉冲发生器将脉冲施加到音频放大器，以便在检测到的振幅时立即重复禁用该音频放大器 电平高于预定的幅度电平门限。
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4.发明授权公开(公告)号：US07439493B2
公开(公告)日：2008-10-21
申请号：US10495407
申请日：2002-11-05
申请人： Pierre Teppaz , Salah Dine Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
发明人： Pierre Teppaz , Salah Dine Qanadli , Guy Cloutier , Gilles Soulez , Richard Cimon , Louis-Gilles Durand
IPC分类号： G01D18/00
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/055 , A61B8/587 , B33Y80/00 , G01R33/58 , G09B23/286
摘要： A multimodality imaging phantom is disclosed which is useful for calibrating devices for imaging vascular conduits. The phantom is compatible with X-ray, ultrasound and magnetic resonance imaging techniques. It allows testing, calibration, and inter-modality comparative study of imaging devices, in static or dynamic flow conditions. It also provides a geometric reference for evaluation of accuracy of imaging devices. The tissue-mimicking material is preferably an agar-based solidified gel. A vessel of known desired geometry runs throughout the gel and is connected to an inlet and outlet at its extremities for generating a flow circulation in the vessel. Said phantom also contains fiducial markers detectable in the above-mentioned modalities. The markers are preferably made of glass and are embedded in a layer of agar gel containing a fat component. The markers are implanted at precise known locations to allow identification and orientation of plane views, and they can be used for calibration, resealing and fusion of 3D images obtained from different modalities, and 3D image reconstruction from angiographic plane views. Also disclosed is a process for manufacturing said phantom.
摘要翻译： 公开了一种多模态成像体模，其用于校准用于成像血管导管的装置。 幻影与X射线，超声和磁共振成像技术兼容。 它允许在静态或动态流动条件下的成像装置的测试，校准和模式间比较研究。 它还提供了用于评估成像设备精度的几何参考。 组织模拟材料优选为基于琼脂的固化凝胶。 具有已知所需几何形状的容器在整个凝胶中运行，并连接到其末端的入口和出口，以在容器中产生流动循环。 所述幻影还包含在上述方式中可检测的基准标记。 标记物优选由玻璃制成并嵌入含有脂肪成分的琼脂凝胶层中。 标记植入在精确的已知位置以允许平面视图的识别和取向，并且它们可用于从不同模态获得的3D图像的校准，重新密封和融合以及来自血管造影平面视图的3D图像重建。 还公开了用于制造所述体模的方法。
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公开(公告)号：US06241683B1
公开(公告)日：2001-06-05
申请号：US09255003
申请日：1999-02-22
IPC分类号： A61B500
摘要： To compensate for the poor signal-to-noise ratio when transforming a patient tracheal sound signal into a respiration flow signal, the transformed signal is used when the sound signal is above a threshold, and interpolated values are used when the sound signal is below the threshold. A volume of breath signal is reliably obtained. Respiration start/stop is detected either by analyzing the sound signal or by physical measurement of the patient. A wearable device incorporating the sound signal processing method can provide an immediate indication or alarm when the volume of breath signal indicates a condition requiring medical attention.
摘要翻译： 为了补偿将患者气管声音信号转换成呼吸流量信号时的差的信噪比，当声音信号高于阈值时使用变换的信号，并且当声音信号低于声音信号时使用内插值 阈。 可靠地获得体积的呼吸信号。 通过分析声音信号或通过患者的物理测量来检测呼吸开始/停止。 结合声音信号处理方法的穿戴式装置可以在呼吸信号指示需要医疗照顾的状况时提供即时指示或警报。
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