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公开(公告)号：US08481533B2
公开(公告)日：2013-07-09
申请号：US13529542
申请日：2012-06-21
申请人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
发明人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
IPC分类号： A61K31/5377 , A61K31/416 , C07D273/01 , C07D231/54
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：US20110263598A1
公开(公告)日：2011-10-27
申请号：US13081254
申请日：2011-04-06
申请人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
发明人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
IPC分类号： A61K31/5377 , A61P35/02 , A61K31/416 , A61P35/00 , C07D487/04 , C07D273/01
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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![Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones](/abs-image/US/2014/12/30/US08921545B2/abs.jpg.150x150.jpg)
3.发明授权Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones 有权手性2-（1H-吲唑-6-基） - 螺[环丙烷-1,3'-二氢吲哚] -2'-酮的合成公开(公告)号：US08921545B2
公开(公告)日：2014-12-30
申请号：US13639648
申请日：2011-04-06
申请人： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
发明人： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC分类号： C07D403/04 , C07D403/10 , C07D413/14 , C07D403/14 , C07D231/56 , A61K31/5377 , A61K45/06
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
摘要翻译： 本发明涉及用于制备由结构式（A）表示的螺环丙基吲哚啉酮化合物的新型合成方法：（A）或其药学上可接受的盐。 还包括本文所述的合成中间体。
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公开(公告)号：US20120264800A1
公开(公告)日：2012-10-18
申请号：US13529542
申请日：2012-06-21
申请人： Peter Brent SAMPSON , Yong LIU , Sze-Wan LI , Bryan T. FORREST , Heinz W. PAULS , Louise G. EDWARDS , Miklos FEHER , Narendra Kumar B. PATEL , Radoslaw LAUFER , Guohua PAN
发明人： Peter Brent SAMPSON , Yong LIU , Sze-Wan LI , Bryan T. FORREST , Heinz W. PAULS , Louise G. EDWARDS , Miklos FEHER , Narendra Kumar B. PATEL , Radoslaw LAUFER , Guohua PAN
IPC分类号： A61K31/416 , A61P35/02 , A61P35/00
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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公开(公告)号：US20120149686A1
公开(公告)日：2012-06-14
申请号：US13262888
申请日：2010-04-06
申请人： Peter B. Sampson , Yong liu , Sze-Wan Le , Brian T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
发明人： Peter B. Sampson , Yong liu , Sze-Wan Le , Brian T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
IPC分类号： A61K31/416 , C07D471/10 , A61K31/437 , C07D401/14 , A61P35/02 , C07D413/14 , A61K31/5377 , A61K31/553 , A61P35/00 , C07D403/10 , A61K31/496
CPC分类号： A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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公开(公告)号：US20130096301A1
公开(公告)日：2013-04-18
申请号：US13639648
申请日：2011-04-06
申请人： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
发明人： Graham Cumming , Narendra Kumar B. Patel , Bryan T. Forrest , Yong Liu , Sze-Wan Li , Peter Brent Sampson , Louise G. Edwards , Heinz W. Pauls
IPC分类号： C07D413/14 , C07D403/14 , C07D231/56 , C07D403/10
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
摘要翻译： 本发明涉及用于制备由结构式（A）表示的螺环丙基吲哚啉酮化合物的新型合成方法：（A）或其药学上可接受的盐。 还包括本文所述的合成中间体。
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公开(公告)号：US08481525B2
公开(公告)日：2013-07-09
申请号：US13262888
申请日：2010-04-06
申请人： Peter Brent Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
发明人： Peter Brent Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/4427 , A61K31/416 , C07D223/14 , C07D273/00 , C07D237/02 , C07D215/00 , C07D231/54
CPC分类号： A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：US08263596B2
公开(公告)日：2012-09-11
申请号：US13081254
申请日：2011-04-06
申请人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer
发明人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer
IPC分类号： A61K31/5377 , A61K31/416 , C07D273/01 , C07D487/04
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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