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    Multiple capillary electrophoresis systems
    1.
    发明授权
    Multiple capillary electrophoresis systems 失效
    多重毛细管电泳系统

    公开(公告)号：US06613212B1

    公开(公告)日：2003-09-02

    申请号：US09402219

    申请日：2000-02-07

    Applicant: Rainer Siebert ,  Samuele Bottani ,  Hans Rebscher ,  Luc Valentin

    Inventor： Rainer Siebert ,  Samuele Bottani ,  Hans Rebscher ,  Luc Valentin

    IPC: C02F140

    CPC classification number: G01N27/44721 ,  G01N27/44782 ,  Y10T436/11

    Abstract: The invention concerns a multiple capillary electrophoresis system including many juxtaposed capillaries, at least one source for transmitting a beam designed to excite the molecules present in its path and inside the capillaries, and detection of the fluorescence of the molecules excited by said beam. The invention is arranged so as to detect the light emerging at the output of said capillaries and propagated along a direction wherein the capillaries extend and the detection resolution is sufficient for distinguishing the light emerging at the output of the capillaries from that coming from the walls thereof and/or their surrounding medium.

    Abstract translation: 本发明涉及一种多毛细管电泳系统，其包括许多并置的毛细血管，至少一个用于透射设计用于激发存在于其毛细管内和毛细管内的分子的光束的源，以及由所述光束激发的分子的荧光的检测。 本发明被布置成检测出在所述毛细管的输出处出现的光并沿着毛细管延伸的方向传播，并且检测分辨率足以区分毛细血管输出处出现的光与来自其的壁的出射 和/或其周围介质。

    Multicapillary electrophoresis systems
    4.
    发明授权
    Multicapillary electrophoresis systems 失效
    多毛细管电泳系统

    公开(公告)号：US07018519B1

    公开(公告)日：2006-03-28

    申请号：US09632573

    申请日：2000-08-04

    Applicant: Rainer Siebert ,  Samuele Bottani ,  Hans Rebscher ,  Luc Valentin ,  Gilbert Gauguet

    Inventor： Rainer Siebert ,  Samuele Bottani ,  Hans Rebscher ,  Luc Valentin ,  Gilbert Gauguet

    IPC: G01N27/453

    CPC classification number: G01N27/44721 ,  G01N27/44782 ,  Y10T436/11

    Abstract: A multicapillary electrophoresis system includes juxtaposed capillaries, at least one source configured for the emission of a light beam intended to excite molecules lying in its path and inside the capillaries and detects the fluorescence of the molecules excited by the light beam. Light that emerges at the exit of the capillaries and that propagates along the direction in that the capillaries extend is detected. The resolution for detection is high enough to distinguish light that emerges at the exit of each of the capillaries. A first liquid is located outside of the capillaries. A second liquid is located inside of the capillaries. The first liquid has a first refractive that is equal to or greater than the refractive index of the second liquid. A mirror is facing the source on the side of the capillaries which is opposed to the source.

    Abstract translation: 多毛细管电泳系统包括并置的毛细管，至少一个源被配置用于发射旨在激发位于其通路内和毛细管内的分子的光束，并且检测由光束激发的分子的荧光。 检测出毛细管出口处的光，并沿毛细管延伸的方向传播。 检测的分辨率足够高，以区分出现在每个毛细管出口处的光。 第一液体位于毛细管外部。 第二液体位于毛细管内部。 第一液体具有等于或大于第二液体的折射率的第一折射率。 镜子正面临与源头相对的毛细管侧面的源头。

    Multiple capillary electrophoresis devices with detection in capillary output
    5.
    发明授权
    Multiple capillary electrophoresis devices with detection in capillary output 失效
    毛细血管输出检测多个毛细管电泳装置

    公开(公告)号：US06485626B1

    公开(公告)日：2002-11-26

    申请号：US09423925

    申请日：2000-01-31

    Applicant: Samuele Bottani ,  Rainer Siebert ,  Hans Rebscher ,  Maurice Cohen-Solal ,  Luc Valentin

    Inventor： Samuele Bottani ,  Rainer Siebert ,  Hans Rebscher ,  Maurice Cohen-Solal ,  Luc Valentin

    IPC: G01N2726

    CPC classification number: G01N27/44782 ,  G01N27/44704

    Abstract: The invention concerns a multiple capillary electrophoresis device comprising a plurality of juxtaposed capillaries, means for generating inside the capillaries an electric field ensuring electrophoretic migration, at least one source for emitting a beam dsigned to exite the molecules at the capillary output, means for detecting the fluorescence of the molecules excited by said beam. The invention also comprises means for generating another electric field, called confinement electric field, which is regularly distributed around said capillaries and which is substantially parallel thereto, said electric field confining the electrophoretic migration field and forcing the molecules to move substantially without divergence in the axis of said capillaries.

    Abstract translation: 本发明涉及一种多毛细管电泳装置，其包括多个并置的毛细管，用于在毛细管内产生确保电泳迁移的电场的装置，至少一个用于发射被排斥以在毛细管输出处排出分子的束的源，用于检测 由所述光束激发的分子的荧光。 本发明还包括用于产生称为限制电场的另一电场的装置，其被规则地分布在所述毛细管周围并且基本上与其平行，所述电场限制了电泳迁移场，并迫使分子基本上在轴线上没有发散 的毛细血管。

    Low light level, high resolution imager using phosphor screen provided with a metal layer for controlling integration cycle of photosensitive matrix array
    6.
    发明授权
    Low light level, high resolution imager using phosphor screen provided with a metal layer for controlling integration cycle of photosensitive matrix array 失效
    低光级，高分辨率成像器使用荧光屏提供金属层，用于控制光敏矩阵阵列的集成周期

    公开(公告)号：US5294788A

    公开(公告)日：1994-03-15

    申请号：US975930

    申请日：1993-04-16

    Applicant: Yves Charon ,  Jean-Marc Gaillard ,  Michel Leblanc ,  Roland Mastrippolito ,  Herve Tricoire ,  Luc Valentin ,  Philippe Laniece

    Inventor： Yves Charon ,  Jean-Marc Gaillard ,  Michel Leblanc ,  Roland Mastrippolito ,  Herve Tricoire ,  Luc Valentin ,  Philippe Laniece

    IPC: G01T1/20 ,  H01J31/50

    CPC classification number: H01J31/50 ,  H01J2231/50015 ,  H01J2231/50063 ,  H01J2231/50094 ,  H01J2231/5016

    Abstract: The present invention relates to a low level, high resolution imager of the type comprising a light-amplifier tube (300) including a photocathode (310), at least one microchannel slab (330) serving as an electron amplifier, and a light-emitting phosphor screen (340) provided with a metal layer (342), an electron camera (400) comprising a photosensitive matrix array (410) suitable for transforming a received photon into an electron, and control means (700) for the electron camera, characterized by the fact that the control means (700) comprise an amplifier (710) responsive to the electrons collected on the metal layer (342) of the light-emitting phosphor screen (340) to control integration cycles of the photosensitive matrix array (410) in repetitive one-shot mode synchronized on the appearance of photons at the input of the light-amplifying tube (300).

    Abstract translation: PCT No.PCT / FR91 / 00680 Sec。 371日期：1993年04月16日 102（e）日期1993年4月16日PCT 1991年8月21日PCT PCT。 出版物WO92 / 03836 本发明涉及一种低电平，高分辨率成像器，其包括包括光电阴极（310）的光放大管（300），至少一个用作电子的微通道板（330） 放大器和设置有金属层（342）的发光荧光屏（340），包括适于将接收到的光子转换成电子的光敏矩阵阵列（410）的电子照相机（400）以及控制装置（700 ），其特征在于控制装置（700）包括响应于在发光荧光屏（340）的金属层（342）上收集的电子的放大器（710），以控制放大器 在光放大管（300）的输入处对光子的出现同步的以重复单次模式的光敏矩阵阵列（410）。

    Very high resolution autofluoroscope for ionizing radiation
    7.
    发明授权
    Very high resolution autofluoroscope for ionizing radiation 失效
    用于电离辐射的非常高分辨率的自动荧光仪

    公开(公告)号：US4973845A

    公开(公告)日：1990-11-27

    申请号：US289012

    申请日：1988-12-22

    Applicant: Roland Mastrippolito ,  Herve Tricoire ,  Luc Valentin ,  Christophe Raymond ,  Michel LeBlanc

    Inventor： Roland Mastrippolito ,  Herve Tricoire ,  Luc Valentin ,  Christophe Raymond ,  Michel LeBlanc

    IPC: G01T1/00 ,  G01T1/164 ,  G01T1/20 ,  G01T5/08

    CPC classification number: G01T1/201 ,  G01T1/1644

    Abstract: A very high resolution radiochromatogram for ionizing radiation comprises at least one array made up of a set of filament-like members adapted to enable spatial marking of a surface to be analyzed according to a specific frame of reference and adapted to detect said radiation by scintillation and to transmit light produced by such detection. The array is formed by two groups of optical fibers. Each fiber is disposed along a respective straight line segment defining two orthogonal directions delimiting an analysis plane or surface. At least one of the groups is subdivided into two elementary groups spaced in a direction perpendicular to the analysis plane or surface. The fibers of the elementary groups are parallel.

    Abstract translation: 用于电离辐射的非常高分辨率的放射色谱包括至少一个由一组灯丝状构件组成的阵列，所述阵列适合于根据特定的参照系对待分析的表面进行空间标记，并适于通过闪烁检测所述辐射， 以透射由这种检测产生的光。 该阵列由两组光纤形成。 每个光纤沿着限定分析平面或表面的两个正交方向的相应直线段设置。 组中的至少一个被细分成沿垂直于分析平面或表面的方向间隔开的两个基本组。 基团的纤维是平行的。

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