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    MULTI-CAPILLARY ELECTROPHORESIS INSTRUMENT
    1.
    发明公开
    MULTI-CAPILLARY ELECTROPHORESIS INSTRUMENT 审中-公开

    公开(公告)号：US20240295527A1

    公开(公告)日：2024-09-05

    申请号：US18567833

    申请日：2021-07-27

    申请人： HITACHI HIGH-TECH CORPORATION

    发明人： Takashi ANAZAWA ,  Motohiro YAMAZAKI ,  Ryoji INABA ,  Shuhei YAMAMOTO

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44782 ,  G01N27/44721

    摘要： In an instrument configured to spectroscopically divide fluorescences emitted from a plurality of capillaries and collectively measure the fluorescences using an image sensor, when the number of pixels of a binning region on the image sensor on which a predetermined wavelength-band component of each fluorescence is projected is denoted by Bm, the number of pixels of hardware binning is denoted by Bh, the number of pixels of software binning is denoted by Bs, Bm=Bh×Bs, the total noise measured in a case where Bm=Bh=Bs=1 is denoted by N, the readout noise is denoted by Nr, the dark-current noise is denoted by Nd, and the shot noise is denoted by Ns, Bm, Bh, Bs, N, Nr, Nd, and Ns satisfy a predetermined relationship, thereby realizing high sensitivity and high dynamic range in fluorescence measurement.

    CAPILLARY-ARRAY-ELECTROPHORESIS DEVICE
    3.
    发明公开
    CAPILLARY-ARRAY-ELECTROPHORESIS DEVICE 审中-公开

    公开(公告)号：US20240044836A1

    公开(公告)日：2024-02-08

    申请号：US18267133

    申请日：2020-12-18

    申请人： HITACHI HIGH-TECH CORPORATION

    发明人： Takashi ANAZAWA ,  Ryoji INABA ,  Shuhei YAMAMOTO

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44721

    摘要： When laser-irradiation portions of N capillaries with capillary numbers n=1, 2, . . . , and N are arranged on a same plane, a laser-irradiation intensity of each capillary is denoted by L(n), and an output intensity of each capillary by a computer when a light emitting substance having an equal concentration exists inside each capillary is denoted by H(n), an absolute value of an average value of a second derivative of H(n) becomes smaller than an absolute value of an average value of a second derivative of L(n) for any refractive index n3 of a separation medium in a range of 1.33≤n3≤1.41 by digital correction by the computer, which changes according to the refractive index n3 (see FIG. 11).

    Sample component separation analysis method
    7.
    发明授权
    Sample component separation analysis method 有权

    公开(公告)号：US11692966B2

    公开(公告)日：2023-07-04

    申请号：US16905075

    申请日：2020-06-18

    申请人： ARKRAY, Inc.

    发明人： Naotsugu Onuma

    IPC分类号： G01N27/447 ,  G01N33/49 ,  G01N27/416

    CPC分类号： G01N27/44721 ,  G01N27/4163 ,  G01N27/44747 ,  G01N33/491

    摘要： There is provided a separation analysis method for analyzing a sample component s included in a sample liquid by introducing the sample liquid into a separation flow path filled with a flow path liquid, the method comprising: obtaining a correction factor representing a proportion of a time period from the first point in time when the sample liquid is introduced into the separation flow path, to the second point in time when an interface between the flow path liquid and the sample liquid reaches a predetermined position at the separation flow path, with respect to a time period from the first point in time to the third point in time when an optical characteristic value of the sample component is measured at the predetermined position, and correcting the measured optical characteristic value with the correction factor.

    Apparatuses for optical and mass spectrometry detection
    9.
    发明授权
    Apparatuses for optical and mass spectrometry detection 有权

    公开(公告)号：US11676807B2

    公开(公告)日：2023-06-13

    申请号：US17545804

    申请日：2021-12-08

    申请人： GMJ Technologies, Inc.

    发明人： Oluwatosin O. Dada

    IPC分类号： H01J49/16 ,  G01N27/447 ,  H01J49/02 ,  H01J49/06

    CPC分类号： H01J49/167 ,  G01N27/44721 ,  H01J49/022 ,  H01J49/025 ,  H01J49/067

    摘要： Presented herein are apparatuses for use in capillary separations. An apparatus includes a coupling that integrates a capillary with a voltage source, a sheath liquid system, a fluid exit port, and a manifold. The coupling may be an elbow connector or equivalent. The manifold receives incident light from an incident light input, and emitted light is collected by a collected light output. The capillary enters the manifold at an input for the capillary, traverses the coupling, and terminates at the fluid exit port, for example an electrospray emitter. The capillary may also enter the manifold at an input for the capillary and terminates inside the manifold.