公开(公告)号：US06394994B1

公开(公告)日：2002-05-28

申请号：US09384765

申请日：1999-08-27

申请人： Nrk Vilambi ,  Bruce M. Eliash ,  Preston Keusch ,  Lue Huai Li ,  Elena N. Chabala ,  Uday K. Jain ,  Louis J. Mestichelli

发明人： Nrk Vilambi ,  Bruce M. Eliash ,  Preston Keusch ,  Lue Huai Li ,  Elena N. Chabala ,  Uday K. Jain ,  Louis J. Mestichelli

IPC分类号： A61M3100

CPC分类号： A61N1/0428

摘要： A method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament includes providing an iontophoretic reservoir-electrode with a contact surface having a shape, a suitable electrical connection and a hydrated bibulous reservoir containing an ionized medicament. The method further includes providing another electrode operating a at preselected polarity opposite to the preselected polarity of the medicament reservoir-electrode. The method further includes providing a separation medium having the property of allowing passage therein to of ions of one charge. The separation medium is positioned between the reservoir electrode with the ionized medicament and the another electrode. The method also includes applying a sufficient electrical potential between the iontophoretic reservoir-electrode containing the ionized medicament and the another iontophoretic reservoir-electrode so that a current flows through the separation medium for a preselected time thereby transporting a quantity of the ionized medicament into the separation medium. The method then includes determining an amount of the ionizable medicament in the separation medium.

摘要翻译： 用于测试离子电渗储存器电极递送药物的能力的方法包括提供具有形状，合适的电连接的接触表面和含有电离药物的水合吸水性储存器的离子电渗储器电极。 该方法还包括提供另外的电极，其操作的预选极性与药物储存器电极的预选极性相反。 该方法还包括提供一种分离介质，该分离介质具有允许通过一次电荷的离子的性质。 分离介质位于储存器电极与电离药物和另一电极之间。 该方法还包括在包含电离药物的离子电渗储存器电极和另一离子电渗储存器电极之间施加足够的电势，使得电流流过分离介质预选的时间，从而将一定量的离子化药物输送到分离 中。 该方法然后包括确定分离介质中的可离子化药物的量。