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公开(公告)号:US5359138A
公开(公告)日:1994-10-25
申请号:US905792
申请日:1992-06-29
申请人: Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
发明人: Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
CPC分类号: C07K5/0202 , C07K7/02 , A61K38/00
摘要: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
摘要翻译: 已经从属于链霉菌的微生物的培养基中分离出一种新的生物活性物质,后抑制素。 该新物质是具有新结构的肽化合物,其中肽链具有酮基。 因此,物质具有高内肽酶抑制活性。 可以在肽链中化学合成具有酮基的后抑制素相关化合物。 这些化合物还具有内肽酶抑制活性。
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公开(公告)号:US5162500A
公开(公告)日:1992-11-10
申请号:US613759
申请日:1990-12-07
申请人: Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
发明人: Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
IPC分类号: A61K38/00 , C07C229/22 , C07C271/22 , C07K5/02 , C07K7/02
CPC分类号: C07C229/22 , C07C271/22 , C07K5/0202 , C07K7/02 , A61K38/00
摘要: A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
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