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    Skin Whitening Agent
    4.
    发明申请
    Skin Whitening Agent 有权
    皮肤美白剂

    公开(公告)号：US20130295207A1

    公开(公告)日：2013-11-07

    申请号：US13979991

    申请日：2012-01-20

    Applicant: Mamiko Kikuchi ,  Daiki Murase ,  Mitsuru Sugiyama ,  Akiko Kawasaki

    Inventor： Mamiko Kikuchi ,  Daiki Murase ,  Mitsuru Sugiyama ,  Akiko Kawasaki

    IPC: A61K8/97 ,  A61Q19/02 ,  A61K8/60 ,  A61K8/49

    CPC classification number: A61K8/97 ,  A23L33/105 ,  A61K8/4973 ,  A61K8/602 ,  A61K31/365 ,  A61K31/7048 ,  A61K36/19 ,  A61K2800/782 ,  A61Q19/02

    Abstract: Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (I) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (I), R1 and R2, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R1 and R2 together form a methylenedioxy group; R3 and R4, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R3 and R4 together form a methylenedioxy group; R5 represents a hydrogen atom, a hydroxyl group, a C1-5 linear or branched alkoxy group, a C1-4 acyl group, or a sugar residue selected from the group consisting of (D-apio-β-D-furanosyl)oxy, (β-D-glucopyranosyl)oxy, (3-O,4-O-dimethyl-D-xylopyranosyl)oxy, (2-O,3-O,4-O-trimethyl-β-D-xylopyranosyl)oxy, and (3-O-methyl-β-D-glucopyranosyl)oxy; R6 and R7 are each a hydrogen atom and R8 and R9 together represent an oxygen atom, or R8 and R9 are each a hydrogen atom and R6 and R7 together represent an oxygen atom.

    Abstract translation: 或其有机溶剂提取物或由下式（I）表示的化合物或其盐用于抑制多巴氧化酶活性，抑制黑色素生成或使皮肤变白的用途; 在式（I）中，R 1和R 2相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 1和R 2一起形成亚甲二氧基; R 3和R 4相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 3和R 4一起形成亚甲二氧基; R5表示氢原子，羟基，C1-5直链或支链烷氧基，C1-4酰基或选自（D-api-β-D-呋喃糖基）氧基， （3-O，4-O-二甲基-D-木吡喃糖基）氧基（2-O，3-O，4-O-三甲基-β-D-吡喃木糖基）氧基和 （3-O-甲基-β-D-吡喃葡萄糖基）氧基; R6和R7各自为氢原子，R8和R9一起表示氧原子，或R8和R9各自为氢原子，R6和R7一起表示氧原子。

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