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    TREATMENT OF NEURODEGENERATIVE DISEASES BY TARGETING MIRNA
    1.
    发明申请
    TREATMENT OF NEURODEGENERATIVE DISEASES BY TARGETING MIRNA 有权
    通过瞄准MIRNA治疗神经损伤性疾病

    公开(公告)号：US20130184331A1

    公开(公告)日：2013-07-18

    申请号：US13822641

    申请日：2011-09-09

    申请人： Jae-Kyu Roh ,  Sang Kun Lee ,  Man Ho Kim ,  Kon Chu ,  Keun-Hwa Jung ,  Soon-Tae Lee

    发明人： Jae-Kyu Roh ,  Sang Kun Lee ,  Man Ho Kim ,  Kon Chu ,  Keun-Hwa Jung ,  Soon-Tae Lee

    IPC分类号： A61K31/7088 ,  C12Q1/68

    CPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.

    摘要翻译： 本发明涉及通过靶向特异性miRNA来预防或治疗神经变性疾病的药物组合物。 此外，本发明涉及用于诊断神经变性疾病的试剂盒。 在阿尔茨海默病和人类大脑样本的两种动物模型中高度表达的本发明中发现的miR-206靶是选择没有神经错误的实质性治疗靶。 作为miR-206的抑制剂的本发明的反义寡核苷酸表明通过靶向miRNA来治疗神经退行性疾病是成功的结果。 本发明的反义寡核苷酸抑制miR-206的功能，大大增加BDNF和IGF-1的水平，并增加突触的再生，从而治疗神经变性疾病，特别是阿尔茨海默氏病。

    Gals-based network-on-chip and data transfer method thereof
    2.
    发明申请
    Gals-based network-on-chip and data transfer method thereof 审中-公开
    基于Gals的片上网络和数据传输方法

    公开(公告)号：US20080005402A1

    公开(公告)日：2008-01-03

    申请号：US11410117

    申请日：2006-04-25

    申请人： Dae-wook Kim ,  Man-ho Kim ,  Gerald Sobelman ,  Eui-seok Kim ,  Sang-woo Rhim ,  Beom-hak Lee

    发明人： Dae-wook Kim ,  Man-ho Kim ,  Gerald Sobelman ,  Eui-seok Kim ,  Sang-woo Rhim ,  Beom-hak Lee

    IPC分类号： G06F5/00

    CPC分类号： G06F1/12

    摘要： A GALS-based network-on-chip (NoC) includes a plurality of asynchronous first-in first-out (FIFO) input buffers connected to a plurality of IPs that asynchronously receive data; a plurality of asynchronous FIFO output buffers connected to the plurality of IPs asynchronously output data; and a router for forwarding data input to the plurality of asynchronous FIFO input buffers, to an asynchronous FIFO output buffer, among the plurality of asynchronous FIFO output buffers, which is connected to an IP to which the data is destined. Accordingly, the system-on-chip (SoC) adopting the GALS design scheme can transfer data via the NoC between the IPs which are in time zones having different clocks in the centralized switching system, thereby avoiding the need for a point-to-point system.

    摘要翻译： 基于GALS的片上网络（NoC）包括多个异步先入先出（FIFO）输入缓冲器，其连接到异步地接收数据的多个IP; 连接到多个IP的多个异步FIFO输出缓冲器异步地输出数据; 以及用于将输入到多个异步FIFO输入缓冲器的数据转发到多个异步FIFO输出缓冲器中的异步FIFO输出缓冲器的路由器，该异步FIFO输出缓冲器连接到数据所指定的IP。 因此，采用GALS设计方案的片上系统（SoC）可以通过NoC在集中式交换系统中具有不同时钟的时区的IP之间传输数据，从而避免了点对点 系统。

    Method of data modulation and demodulation in SoC
    3.
    发明申请
    Method of data modulation and demodulation in SoC 审中-公开
    SoC中的数据调制和解调方法

    公开(公告)号：US20070115798A1

    公开(公告)日：2007-05-24

    申请号：US11289544

    申请日：2005-11-30

    申请人： Gerald Sobelman ,  Dae-wook Kim ,  Man-ho Kim ,  Beam-hak Lee ,  Eui-seok Kim ,  Sang-woo Rhim

    发明人： Gerald Sobelman ,  Dae-wook Kim ,  Man-ho Kim ,  Beam-hak Lee ,  Eui-seok Kim ,  Sang-woo Rhim

    IPC分类号： H04J11/00

    CPC分类号： H04B1/707

    摘要： A method of modulating data, which is represented by two data types of ‘high’ and ‘low’, and demodulating the modulated data, is disclosed. In a method of data modulation and demodulation for a communication system which has a transmitting end modulating a data and a receiving end demodulating the transmitted data from the transmitting end, the data is represented by two types including ‘high’ and ‘low’, and the receiving end receives at least one data which consists of at least one code-word spread by a unique orthogonal code. The receiving end adds up the received data in the unit of code-word, and subtracts the length of the orthogonal code from a value which is obtained by doubling the sum of the code-word, when the code-word of the orthogonal code is ‘0’. The receiving end then averages the result after the subtraction in the unit of orthogonal code length and e-tracts the result, and therefore obtains the data from the transmitting end.

    摘要翻译： 公开了一种调制数据的方法，它由两种数据类型“高”和“低”表示，并解调调制数据。 在具有发送端调制数据的通信系统和从发送端解调发送数据的接收端的通信系统的数据调制和解调方法中，数据由“高”和“低”两种类型表示， 接收端接收由至少一个由唯一正交码扩展的码字组成的至少一个数据。 接收端以码字为单位将接收到的数据相加，并从正交码的码字的倍数为2倍的值中减去正交码的长度， '0'。 然后，接收端在以正交码长度为单位的减法之后对结果进行平均，并且将结果进行电子邮件发送，从而从发送端获取数据。

    Treatment of neurodegenerative diseases by targeting miRNA
    4.
    发明授权
    Treatment of neurodegenerative diseases by targeting miRNA 有权
    通过靶向miRNA治疗神经退行性疾病

    公开(公告)号：US09301969B2

    公开(公告)日：2016-04-05

    申请号：US13822641

    申请日：2011-09-09

    申请人： Jae-Kyu Roh ,  Sang Kun Lee ,  Man Ho Kim ,  Kon Chu ,  Keun-Hwa Jung ,  Soon-Tae Lee

    发明人： Jae-Kyu Roh ,  Sang Kun Lee ,  Man Ho Kim ,  Kon Chu ,  Keun-Hwa Jung ,  Soon-Tae Lee

    IPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  C12Q1/68

    CPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.

    摘要翻译： 本发明涉及通过靶向特异性miRNA来预防或治疗神经变性疾病的药物组合物。 此外，本发明涉及用于诊断神经变性疾病的试剂盒。 在阿尔茨海默病和人类大脑样本的两种动物模型中高度表达的本发明中发现的miR-206靶是选择没有神经错误的实质性治疗靶。 作为miR-206的抑制剂的本发明的反义寡核苷酸表明通过靶向miRNA来治疗神经退行性疾病是成功的结果。 本发明的反义寡核苷酸抑制miR-206的功能，大大增加BDNF和IGF-1的水平，并增加突触的再生，从而治疗神经变性疾病，特别是阿尔茨海默氏病。

    Switching device of networks-on-chip system and scheduling method thereof
    5.
    发明授权
    Switching device of networks-on-chip system and scheduling method thereof 有权
    网络片上系统的切换装置及其调度方法

    公开(公告)号：US07697563B2

    公开(公告)日：2010-04-13

    申请号：US11326327

    申请日：2006-01-06

    申请人： Gerald E. Sobelman ,  Man-ho Kim ,  Daewook Kim ,  Sang-woo Rhim ,  Eui-seok Kim ,  Beom-hak Lee

    发明人： Gerald E. Sobelman ,  Man-ho Kim ,  Daewook Kim ,  Sang-woo Rhim ,  Eui-seok Kim ,  Beom-hak Lee

    IPC分类号： H04J3/02

    CPC分类号： H04L12/66 ,  H04J13/0003 ,  H04J13/0048 ,  H04L49/109 ,  H04L49/3045 ,  H04L49/503

    摘要： A switching device of NoC (Networks on Chip) system and a scheduling method thereof. The switching device has a switching part having a plurality of input ports and a plurality of output ports, and a scheduler for setting a transmission route between the input ports and the output ports, determining the length of code based on the number of input ports having the data among the plurality of input ports, and assigning a predetermined code of the determined code length to the input port and the output port corresponding to the set transmission route. Because the code length is adjustably varied according to the number of transmission packets, switch performance improves.

    摘要翻译： NoC（片上网络）系统的切换装置及其调度方法。 开关装置具有具有多个输入端口和多个输出端口的开关部件，以及用于设定输入端口和输出端口之间的传输路径的调度器，基于具有 多个输入端口之间的数据，并且将所确定的代码长度的预定代码分配给与所设置的传输路由对应的输入端口和输出端口。 由于代码长度可根据传输数据包的数量进行调整，切换性能提高。

    METHOD AND APPARATUS FOR TAKING PICTURES ON A MOBILE COMMUNICATION TERMINAL HAVING A CAMERA MODULE
    6.
    发明申请
    METHOD AND APPARATUS FOR TAKING PICTURES ON A MOBILE COMMUNICATION TERMINAL HAVING A CAMERA MODULE 有权
    在具有摄像机模块的移动通信终端上拍摄照片的方法和装置

    公开(公告)号：US20100056211A1

    公开(公告)日：2010-03-04

    申请号：US12553550

    申请日：2009-09-03

    申请人： Dong-Youl PARK ,  Young-Kwon Yoon ,  Yeon-Jun Lee ,  Jung-Tae Kwon ,  Man-Ho Kim

    发明人： Dong-Youl PARK ,  Young-Kwon Yoon ,  Yeon-Jun Lee ,  Jung-Tae Kwon ,  Man-Ho Kim

    IPC分类号： H04M1/00 ,  H04N5/228

    CPC分类号： H04N5/23248 ,  H04N5/142 ,  H04N5/145 ,  H04N5/23254

    摘要： A method and an apparatus for taking pictures on a mobile communication terminal having a camera module are provided, which can control the photographing of an object in accordance with the motion of the object. The method includes generating a current frame by photographing an object, determining whether blurring has occurred in the current frame, measuring an amount of motion of the current frame if no blurring has occurred in the generated current frame, and storing the current frame if the measured amount of motion is greater than a pre-stored reference amount of motion.

    摘要翻译： 提供了一种用于在具有相机模块的移动通信终端上拍摄图像的方法和装置，其可以根据对象的运动来控制对象的拍摄。 该方法包括通过拍摄对象来生成当前帧，确定当前帧中是否发生模糊，如果在生成的当前帧中没有发生模糊，则测量当前帧的运动量，并且如果测量到的，存储当前帧 运动量大于预先存储的参考运动量。

    Liquid crystal display device having black/white LCD panel
    7.
    发明申请
    Liquid crystal display device having black/white LCD panel 审中-公开
    具有黑/白液晶显示面板的液晶显示装置

    公开(公告)号：US20080273147A1

    公开(公告)日：2008-11-06

    申请号：US12150198

    申请日：2008-04-25

    申请人： Man-Ho Kim ,  Seong-Ha Park ,  Joong-Wan Park

    发明人： Man-Ho Kim ,  Seong-Ha Park ,  Joong-Wan Park

    IPC分类号： G02F1/1335

    CPC分类号： G02F1/133621

    摘要： Disclosed is a Liquid Crystal Display (LCD) device including a black/white LCD panel for displaying an image, a color filter disposed on a rear surface of the black/white LCD panel in order to filter input light into light of preset colors and output the filtered light to the black/white LCD panel, and a back light unit having a plurality of optical sheets to output white light to the color filter. The color filter is integrated with one of the plurality of optical sheets as one piece.

    摘要翻译： 公开了一种液晶显示器（LCD）装置，其包括用于显示图像的黑/白LCD面板，设置在黑/白LCD面板的后表面上的滤色器，以便将输入光过滤成预设颜色的光并输出 经过滤光到黑/白液晶显示面板，背光单元具有多个光学片以将白光输出到滤色器。 滤色片与多个光学片之一一体化。

    Method and apparatus for taking pictures on a mobile communication terminal having a camera module
    9.
    发明授权
    Method and apparatus for taking pictures on a mobile communication terminal having a camera module 有权
    在具有相机模块的移动通信终端上拍摄照片的方法和装置

    公开(公告)号：US07929853B2

    公开(公告)日：2011-04-19

    申请号：US12553550

    申请日：2009-09-03

    申请人： Dong-Youl Park ,  Young-Kwon Yoon ,  Yeon-Jun Lee ,  Jung-Tae Kwon ,  Man-Ho Kim

    发明人： Dong-Youl Park ,  Young-Kwon Yoon ,  Yeon-Jun Lee ,  Jung-Tae Kwon ,  Man-Ho Kim

    IPC分类号： G03B17/00

    CPC分类号： H04N5/23248 ,  H04N5/142 ,  H04N5/145 ,  H04N5/23254

    摘要： A method and an apparatus for taking pictures on a mobile communication terminal having a camera module are provided, which can control the photographing of an object in accordance with the motion of the object. The method includes generating a current frame by photographing an object, determining whether blurring has occurred in the current frame, measuring an amount of motion of the current frame if no blurring has occurred in the generated current frame, and storing the current frame if the measured amount of motion is greater than a pre-stored reference amount of motion.

    摘要翻译： 提供了一种用于在具有相机模块的移动通信终端上拍摄图像的方法和装置，其可以根据对象的运动来控制对象的拍摄。 该方法包括通过拍摄对象来生成当前帧，确定当前帧中是否发生模糊，如果在生成的当前帧中没有发生模糊，则测量当前帧的运动量，并且如果测量到的，存储当前帧 运动量大于预先存储的参考运动量。

    BACK LIGHT UNIT
    10.
    发明申请
    BACK LIGHT UNIT 审中-公开
    后灯单元

    公开(公告)号：US20080151574A1

    公开(公告)日：2008-06-26

    申请号：US11958426

    申请日：2007-12-18

    申请人： Joong-Wan PARK ,  Man-Ho Kim ,  Seong-Ha Park

    发明人： Joong-Wan PARK ,  Man-Ho Kim ,  Seong-Ha Park

    IPC分类号： F21V7/04 ,  H01J9/02

    CPC分类号： G02B6/0055 ,  G02B6/0081 ,  G02F1/133615

    摘要： A back light unit and a method of manufacture that can provide a backlight unit suitable for a Liquid Crystal Display (LCD) device includes a bezel, a reflection layer arranged onto the bezel, and a light guide plate disposed on the reflection layer. The reflection layer can be coated onto the bezel, and may include a reflective material that includes a metal such as silver or aluminum, or an alloy thereof. The back light unit can be significantly slimmer than previously known while providing good optical characteristics for a number of different lighting conditions.

    摘要翻译： 可以提供适用于液晶显示器（LCD）装置的背光单元的背光单元和制造方法包括边框，布置在边框上的反射层和布置在反射层上的导光板。 反射层可以涂覆在边框上，并且可以包括包括诸如银或铝的金属或其合金的反射材料。 背光单元可以比以前已知的轻得多，同时为许多不同的照明条件提供良好的光学特性。