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1.发明授权公开(公告)号：US08426629B2
公开(公告)日：2013-04-23
申请号：US12991931
申请日：2009-05-14
IPC分类号： C07F9/28
CPC分类号： C25B3/04 , C07F9/5022 , C07F9/509 , C07F9/65515 , Y02P20/582
摘要： Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP═O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.
摘要翻译： 公开了一种由氧化膦衍生物制备膦衍生物的方法，其包括以下步骤：（I）将式（1）表示的氧化膦衍生物与氯化剂在极性有机溶剂中混合，引起它们之间的反应 组件; 和（II-1）将具有等于或低于铝的电离倾向的金属的盐加入到反应混合物中并在铝的存在下进行还原反应或（II-2）使反应混合物 电解还原，从而制得由式（2）表示的膦衍生物。 ArnR3-nP = O（1）ArnR3-nP（2）在式（1）和（2）中，Ar表示芳基，例如苯基，具有取代基的苯基，杂芳族环基和杂芳族 具有取代基的环基; R表示脂肪族烃基或具有取代基的脂族烃基; n表示0〜3的整数。
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公开(公告)号：US20100113769A1
公开(公告)日：2010-05-06
申请号：US12530307
申请日：2008-03-06
IPC分类号： C07D499/10
CPC分类号： C07D499/04 , C07D499/861 , C07D499/897 , Y02P20/55
摘要： The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom;the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom;reacting the generated compound with an amine compound; andfurther reacting the generated compound with acetaldehyde.
摘要翻译： 本发明提供一种可以高选择性制备下述通式（2）所示的6-羟基乙基青霉烷化合物的方法：其中R表示氢原子或羧酸保护基，X2表示卤素原子; 该方法包括以下步骤：使格利雅试剂与由以下通式（1）表示的卤代双酚化合物反应：其中R和X 2与上述相同，X 1表示卤素原子; 使所生成的化合物与胺化合物反应; 并进一步使生成的化合物与乙醛反应。
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公开(公告)号：US08293893B2
公开(公告)日：2012-10-23
申请号：US12530307
申请日：2008-03-06
IPC分类号： C07D499/04 , C07D499/861
CPC分类号： C07D499/04 , C07D499/861 , C07D499/897 , Y02P20/55
摘要： The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and X2 represents a halogen atom; the method including the steps of reacting a Grignard reagent with a halogeno penam compound represented by General Formula (1) below: wherein R and X2 are the same as above, and X1 represents a halogen atom; reacting the generated compound with an amine compound; and further reacting the generated compound with acetaldehyde.
摘要翻译： 本发明提供一种可以高选择性制备下述通式（2）所示的6-羟基乙基青霉烷化合物的方法：其中R表示氢原子或羧酸保护基，X2表示卤素原子; 该方法包括以下步骤：使格利雅试剂与由以下通式（1）表示的卤代双酚化合物反应：其中R和X 2与上述相同，并且X 1表示卤素原子; 使所生成的化合物与胺化合物反应; 并进一步使生成的化合物与乙醛反应。
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4.发明申请公开(公告)号：US20110065961A1
公开(公告)日：2011-03-17
申请号：US12991931
申请日：2009-05-14
IPC分类号： C07F9/50
CPC分类号： C25B3/04 , C07F9/5022 , C07F9/509 , C07F9/65515 , Y02P20/582
摘要： Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP═O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.
摘要翻译： 公开了一种由氧化膦衍生物制备膦衍生物的方法，其包括以下步骤：（I）将式（1）表示的氧化膦衍生物与氯化剂在极性有机溶剂中混合，引起它们之间的反应 组件; 和（II-1）将具有等于或低于铝的电离倾向的金属的盐加入到反应混合物中并在铝的存在下进行还原反应或（II-2）使反应混合物 电解还原，从而制得由式（2）表示的膦衍生物。 ArnR3-nP=O（1）ArnR3-nP（2）式（1）和（2）中，Ar表示苯基，具有取代基的苯基，杂芳环，杂芳基等芳基 具有取代基的环基; R表示脂肪族烃基或具有取代基的脂族烃基; n表示0〜3的整数。
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