公开(公告)号：US08470327B2

公开(公告)日：2013-06-25

申请号：US13138941

申请日：2010-05-06

申请人： Mark Throsby ,  Robert Heinz Edward Friesen ,  Theodorus Hendrikus Jacobus Kwaks ,  Mandy Antonia Catharina Jongeneelen

发明人： Mark Throsby ,  Robert Heinz Edward Friesen ,  Theodorus Hendrikus Jacobus Kwaks ,  Mandy Antonia Catharina Jongeneelen

IPC分类号： A61K39/145 ,  C12Q1/70 ,  C07K16/10

CPC分类号： C07K16/1018 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/16111

摘要： Binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. Provided are nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. The antibodies may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.

摘要翻译： 结合分子，如人单克隆抗体，其结合包含H3亚型HA的流感病毒，如H3N2，并且具有对这种流感病毒的广泛的中和活性。 提供编码抗体的核酸分子，其序列和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H3N2感染。 抗体可以提供跨亚型保护，使得可以预防和/或治疗H3，H7和/或H10基的流感亚型的感染。

公开(公告)号：US20120039898A1

公开(公告)日：2012-02-16

申请号：US13138941

申请日：2010-05-06

申请人： Mark Throsby ,  Robert Heinz Edward Friesen ,  Theodorus Hendrikus Jacobus Kwaks ,  Mandy Antonia Catharina Jongeneelen

发明人： Mark Throsby ,  Robert Heinz Edward Friesen ,  Theodorus Hendrikus Jacobus Kwaks ,  Mandy Antonia Catharina Jongeneelen

IPC分类号： A61K39/395 ,  C12Q1/70 ,  A61P31/16 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00 ,  C07K16/10 ,  C12N15/12

CPC分类号： C07K16/1018 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/16111

摘要： Binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. Provided are nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. The antibodies may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.

摘要翻译： 结合分子，如人单克隆抗体，其结合包含H3亚型HA的流感病毒，如H3N2，并且具有对这种流感病毒的广泛的中和活性。 提供编码抗体的核酸分子，其序列和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H3N2感染。 抗体可以提供跨亚型保护，使得可以预防和/或治疗H3，H7和/或H10基的流感亚型的感染。