公开(公告)号：US3968154A

公开(公告)日：1976-07-06

申请号：US518872

申请日：1974-10-29

申请人： Manfred Klaus Joachim Bock, deceased

发明人： Manfred Klaus Joachim Bock, deceased

IPC分类号： C07F3/10 ,  C07C149/243

CPC分类号： C07F3/103

摘要： This invention relates to the production of penicillamine and acid addition salts of penicillamine through the production from penilloic acid or penicilloic acid formed by hydrolytic decomposition of a penicillin of penicillamine-mercuric-mercaptide which can be easily decomposed by means of hydrogen sulfide to penicillamine. The penicillamine-mercuric-mercaptide is formed as a crystalline precipitate by reaction of the penicilloic acid or penilloic acid with a mercuric salt in a ratio of 1:0.5 in a medium of a water miscible organic solvent and the precipitated penicillamine-mercuric-mercaptide after separation from the reaction medium is decomposed to the penicillamine.

摘要翻译： 本发明涉及青霉胺和青霉胺酸加成盐的生产，通过由青霉素 - 汞 - 硫醇盐的青霉素分解形成的青霉素或青霉素生成青霉素，其可以通过硫化氢容易地分解成青霉胺。 青霉胺 - 汞 - 硫醇盐通过在水混溶性有机溶剂的介质和沉淀的青霉胺 - 汞 - 硫醇盐的混合溶剂中的比例为1:0.5的比例将青霉素酸或者阴离子酸与汞盐反应形成为结晶沉淀物， 与反应介质的分离被分解成青霉胺。