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    Acyclic Sulfamide Derivatives
    4.
    发明申请
    Acyclic Sulfamide Derivatives 有权
    非环状磺酰胺衍生物

    公开(公告)号：US20100179224A2

    公开(公告)日：2010-07-15

    申请号：US12162035

    申请日：2007-01-26

    申请人： Fernando Antonio RODRIGUEZ DE FONSECA ,  Manuel MACIAS GONZALEZ ,  Javier PAVON MORON ,  María Pilar GOYA-LAZA ,  Juan Antonio PAEZ PROSPER ,  Carolina CANO RAMOS

    发明人： Fernando Antonio RODRIGUEZ DE FONSECA ,  Manuel MACIAS GONZALEZ ,  Javier PAVON MORON ,  María Pilar GOYA-LAZA ,  Juan Antonio PAEZ PROSPER ,  Carolina CANO RAMOS

    IPC分类号： A61K31/16 ,  C07C307/06 ,  A61P3/10 ,  A61P9/00

    CPC分类号： C07C307/06 ,  A61K8/466 ,  A61Q19/06

    摘要： The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.

    摘要翻译： 本发明涉及式（I）的无环硫酰胺衍生物，其中当R 1和R 2不同时，R 1和R 2可以相同或不同，R 1是直链C 12 -C 20烷基或直链C 12 -C 20烯基 包括1,2或3或4个双键; 并且R 2是氢原子或C 1 -C 4烷基，或者当R 1和R 2相同时，R 1和R 2是直链C 14 -C 20烷基或具有1,2,3或4的直链C 14 -C 20链烯基 双键及其药学上可接受的盐，溶剂合物和水合物，其可用于制备用于饱和感应和摄取控制，脂肪调节和脂质代谢调节的药物，并且用于制备用于治疗或预防糖尿病和心血管的药物 疾病 无环硫酰胺衍生物也可用于化妆品用于减少皮下脂肪。