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公开(公告)号:US20100297263A1
公开(公告)日:2010-11-25
申请号:US12852473
申请日:2010-08-07
Applicant: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Inventor: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.
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公开(公告)号:US20170119816A1
公开(公告)日:2017-05-04
申请号:US15407080
申请日:2017-01-16
Applicant: Marc Halphen , Hans-Jurgen GRUSS , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
Inventor: Marc Halphen , Hans-Jurgen GRUSS , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
IPC: A61K33/14 , A61K9/08 , A61K9/00 , A61K31/375 , A61K31/765
CPC classification number: A61K33/14 , A61K9/0095 , A61K9/08 , A61K31/375 , A61K31/765 , A61K31/77 , A61K33/04 , A61K47/02 , A61K47/22 , A61K2300/00
Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: —administering to the subject an effect amount of a first cleansing solution; and then after a time interval —administering to the subject an effective amount of a second cleansing solution, wherein the two cleansing solutions are as described in the specification.
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公开(公告)号:US09592252B2
公开(公告)日:2017-03-14
申请号:US14004604
申请日:2012-03-09
Applicant: Marc Halphen , Hans-Jurgen Gruss , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
Inventor: Marc Halphen , Hans-Jurgen Gruss , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
IPC: A61K31/375 , A61K31/765 , A61K47/06 , A61K47/22 , A61K9/08 , A61K33/04 , A61K33/14 , A61K9/00 , A61K47/02
CPC classification number: A61K33/14 , A61K9/0095 , A61K9/08 , A61K31/375 , A61K31/765 , A61K31/77 , A61K33/04 , A61K47/02 , A61K47/22 , A61K2300/00
Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per liter ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: —administering to the subject an effective amount of a first cleansing solution; and then after a time interval —administering to the subject an effective amount of a second cleansing solution, where in the two cleansing solutions are as described in the specification.
Abstract translation: 本发明提供一种结肠清洗溶液,其包含:a)每升抗坏血酸阴离子300至2000mmol,由抗坏血酸,一种或多种抗坏血酸盐或其混合物提供; 和b)10至200g /升聚乙二醇。 本发明还提供与溶液相关联或利用该溶液的方法和试剂盒。 本发明还提供了一种清洁受试者的结肠的方法,包括:向受试者提供有效量的第一清洁溶液; 然后在时间间隔之后 - 向受试者提供有效量的第二清洁溶液,其中两种清洁溶液如说明书中所述。
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公开(公告)号:US20100189815A1
公开(公告)日:2010-07-29
申请号:US12754161
申请日:2010-04-05
Applicant: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Inventor: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected from the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.
Abstract translation: 一种组合物,其包含每升水溶液30至350g聚乙二醇,3至20g选自抗坏血酸,抗坏血酸盐或其混合物的抗坏血酸组分,碱 金属或碱土金属硫酸盐,优选其1至15g,以及任选的一种或多种选自氯化钠,氯化钾和碳酸氢钠的电解质,并且优选还包含调味剂,在清洁肠道中有效,以制备 内镜检查,特别是结肠镜检查。 它比常规磷酸钠基肠清洁组合物更安全,因此可用于使用基于磷酸钠的组合物处于危险中的患者,并且比常规的基于PEG的组合物更耐受,导致更好的患者依从性和使能 有效的门诊使用。
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公开(公告)号:US07658914B2
公开(公告)日:2010-02-09
申请号:US11636105
申请日:2006-12-08
Applicant: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Inventor: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
CPC classification number: A61K9/009 , A61K9/0095 , A61K31/375 , A61K31/765 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/14 , A61K45/06 , Y10S514/892 , A61K2300/00
Abstract: A composition comprising, per liter of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavorings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.
Abstract translation: 一种组合物,其包含每升水溶液30至350g聚乙二醇,3至20g抗坏血酸组分,选自抗坏血酸,抗坏血酸盐或其混合物,碱 金属或碱土金属硫酸盐,优选其1至15g,以及任选的一种或多种选自氯化钠,氯化钾和碳酸氢钠的电解质,并且优选还包含调味剂,在清洁肠道中有效,以制备 内镜检查,特别是结肠镜检查。 它比常规磷酸钠基肠清洁组合物更安全,因此可用于使用基于磷酸钠的组合物处于危险中的患者,并且比常规的基于PEG的组合物更耐受,导致更好的患者依从性和使能 有效的门诊使用。
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公开(公告)号:US20100196513A1
公开(公告)日:2010-08-05
申请号:US12753949
申请日:2010-04-05
Applicant: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Inventor: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.
Abstract translation: 一种组合物,其包含每升水溶液30至350g聚乙二醇,3至20g抗坏血酸组分,选自抗坏血酸,抗坏血酸盐或其混合物,碱 金属或碱土金属硫酸盐,优选其1至15g,以及任选的一种或多种选自氯化钠,氯化钾和碳酸氢钠的电解质,并且优选还包含调味剂,在清洁肠道中有效,以制备 内镜检查,特别是结肠镜检查。 它比常规磷酸钠基肠清洁组合物更安全,因此可用于使用基于磷酸钠的组合物处于危险中的患者,并且比常规的基于PEG的组合物更耐受,导致更好的患者依从性和使能 有效的门诊使用。
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公开(公告)号:US20100086624A1
公开(公告)日:2010-04-08
申请号:US12633663
申请日:2009-12-08
Applicant: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Inventor: Norman Barras , Ian David Cox , Alex Ungar , Marc Halphen
Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.
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公开(公告)号:US20140010895A1
公开(公告)日:2014-01-09
申请号:US14004604
申请日:2012-03-09
Applicant: Marc Halphen , Hans-Jurgen Gruss , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
Inventor: Marc Halphen , Hans-Jurgen Gruss , Ian Cox , Alasdair Cockett , Peter Stein , Alex Ungar
IPC: A61K31/765 , A61K33/04 , A61K31/375 , A61K33/14
CPC classification number: A61K33/14 , A61K9/0095 , A61K9/08 , A61K31/375 , A61K31/765 , A61K31/77 , A61K33/04 , A61K47/02 , A61K47/22 , A61K2300/00
Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: — administering to the subject an effective amount of a first cleansing solution; and then after a time interval-administering to the subject an effective amount of a second cleansing solution, where in the two cleansing solutions are as described in the specification.
Abstract translation: 本发明提供一种结肠清洗溶液,其包含:a)每升抗坏血酸阴离子300至2000mmol,由抗坏血酸,一种或多种抗坏血酸盐或其混合物提供; 和b)10至200g /升聚乙二醇。 本发明还提供与溶液相关联或利用该溶液的方法和试剂盒。 本发明还提供一种清洁受试者结肠的方法,包括: - 向受试者施用有效量的第一清洁溶液; 然后经过一段时间间隔 - 向受试者施用有效量的第二清洁溶液,其中两种清洁溶液如说明书中所述。
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