公开(公告)号：US20240358782A1

公开(公告)日：2024-10-31

申请号：US17923773

申请日：2021-04-30

申请人： Victor Abou Nehmi Filho ,  José Pinhata Otoch ,  Ana Flávia Marçal Pessoa

发明人： Victor Abou Nehmi Filho ,  José Pinhata Otoch ,  Ana Flávia Marçal Pessoa

IPC分类号： A61K36/064 ,  A61K31/353 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/716 ,  A61K33/04 ,  A61K33/06 ,  A61K33/30 ,  A61K36/28 ,  A61P43/00

CPC分类号： A61K36/064 ,  A61K31/353 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/716 ,  A61K33/04 ,  A61K33/06 ,  A61K33/30 ,  A61K36/28 ,  A61P43/00

摘要： The present invention deals with the composition of Betaglucans and Silymarin—Silybum marianum and one or more Bifidogenic Prebiotics, for use as a nutritional supplement, or nutraceutical, or as a prebiotic, aiming to modulate the neuro-immune-endocrine axis, via protection and preservation of the intestinal epithelium. and liver. Having as main objective to provide better quality of sleep. The composition according to the invention comprises the following components: —1,3 and 1,6 beta-glucans; —Silymarin (Silybum marianum), or its natural or synthetic flavonolignans or flavonoids; and —one or more Bifidogenic Prebiotics.

公开(公告)号：US20240350516A1

公开(公告)日：2024-10-24

申请号：US18759260

申请日：2024-06-28

申请人： Azura Ophthalmics Ltd.

发明人： Yair ALSTER ,  Omer RAFAELI ,  Kirsten Angela MACFARLANE ,  Cary REICH ,  Shimon AMSELEM ,  Doron FRIEDMAN

IPC分类号： A61K31/60 ,  A61K8/22 ,  A61K8/23 ,  A61K9/00 ,  A61K9/06 ,  A61K31/122 ,  A61K31/17 ,  A61K31/19 ,  A61K31/327 ,  A61K31/4015 ,  A61K31/555 ,  A61K33/04 ,  A61K35/04

CPC分类号： A61K31/60 ,  A61K8/22 ,  A61K8/23 ,  A61K9/0048 ,  A61K9/06 ,  A61K31/122 ,  A61K31/17 ,  A61K31/19 ,  A61K31/327 ,  A61K31/4015 ,  A61K31/555 ,  A61K33/04 ,  A61K35/04 ,  A61K9/0014

摘要： Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.

公开(公告)号：US20240350443A1

公开(公告)日：2024-10-24

申请号：US18294559

申请日：2022-08-09

申请人： WUHAN GRAND HOYO CO., LTD.

发明人： Lei YANG ,  Chengjun ZHU ,  Wenwen ZHANG ,  Panpan XING ,  Xiaomeng WANG ,  Haixia SU ,  Liyan ZHA ,  Dawei LIU ,  Hao FENG

IPC分类号： A61K31/198 ,  A61K9/20 ,  A61K9/48 ,  A61K31/145 ,  A61K33/04 ,  A61K33/30 ,  A61P1/16

CPC分类号： A61K31/198 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2068 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/145 ,  A61K33/04 ,  A61K33/30 ,  A61P1/16

摘要： A composition, formulation, preparation method and use for a glutathione precursor. The composition comprises, in parts by weight: a selenium-containing compound; a glutathione precursor; a zinc-containing compound. A powder obtained by mixing the present composition has good mixing uniformity and good fluidity, and facilitates filling in a filling capsule; and a capsule containing the composition has the effects of liver protection, oxidation resistance, and immunity enhancement.

公开(公告)号：US12083179B2

公开(公告)日：2024-09-10

申请号：US17384227

申请日：2021-07-23

申请人： NORGINE BV

发明人： Lucy Clayton ,  Alasdair Cockett ,  Mark Christodoulou ,  Ian Davidson ,  Lynn Farrag ,  Marc Halphen ,  Leighton Jones ,  Vanik Petrossian ,  Peter Stein ,  David Tisi ,  Alex Ungar ,  Jeffrey Worthington

IPC分类号： A61K47/26 ,  A61K9/00 ,  A61K9/08 ,  A61K31/047 ,  A61K31/375 ,  A61K31/765 ,  A61K31/77 ,  A61K33/04 ,  A61K33/14 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12

CPC分类号： A61K47/26 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/047 ,  A61K31/375 ,  A61K31/765 ,  A61K31/77 ,  A61K33/04 ,  A61K33/14 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K31/375 ,  A61K2300/00 ,  A61K31/765 ,  A61K2300/00 ,  A61K31/77 ,  A61K2300/00

摘要： The invention provides a colon cleansing solution comprising:



a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of:

(i) ascorbic acid and
(ii) one or more salts of ascorbic acid
the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and


b) 10 to 200 g per litre polyethylene glycol.




The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.

公开(公告)号：US20240285679A1

公开(公告)日：2024-08-29

申请号：US18573953

申请日：2022-06-22

申请人： Azura Ophthalmics Ltd.

发明人： Charles BOSWORTH ,  Yair ALSTER ,  Hila EPSTEIN-BARASH ,  Omer RAFAELI ,  Marc GLEESON

IPC分类号： A61K33/04 ,  A61K9/00 ,  A61P27/10

CPC分类号： A61K33/04 ,  A61K9/0048 ,  A61P27/10

摘要： Described herein are compositions and methods for the treatment of vision loss and/or dry eye syndrome. Such compositions comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of such compositions to the inner surface of the eyelid provides therapeutic benefit to patients suffering from vision loss and/or dry eye syndrome.

公开(公告)号：US20240277607A1

公开(公告)日：2024-08-22

申请号：US18643713

申请日：2024-04-23

申请人： American Regent, Inc.

发明人： Richard Lawrence ,  Jasmina Marinkovic ,  Gopal Anyarambhatla

IPC分类号： A61K9/00 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/14 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61K36/48 ,  A61P3/02 ,  A61P3/12 ,  A61P3/14

CPC分类号： A61K9/0029 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/14 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61K36/48 ,  A61P3/02 ,  A61P3/12 ,  A61P3/14

摘要： A parenteral nutrition including at least one of an amino acid, a dextrose, a lipid, an electrolyte or a mixture thereof and a trace element including at least one of zinc, copper, selenium, or manganese is provided. The parenteral nutrition including the trace element is stable for about at least 3 days to about 14 days. Methods of preparing and using the stable injectable parenteral nutrition are also provided.

公开(公告)号：US20240269162A1

公开(公告)日：2024-08-15

申请号：US18445785

申请日：2024-02-01

申请人： Kedar Prasad

发明人： Kedar Prasad

IPC分类号： A61K31/714 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K33/04 ,  A61K33/06 ,  A61K33/30 ,  A61P39/00

CPC分类号： A61K31/714 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K33/04 ,  A61K33/06 ,  A61K33/30 ,  A61P39/00

摘要： A formulation comprising at least one vitamin, at least one antioxidant, at least one mineral, at least one plant based nutrient and sodium.

公开(公告)号：US20240245581A1

公开(公告)日：2024-07-25

申请号：US18587014

申请日：2024-02-26

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

发明人： Freddy Desbrosses ,  Pierpaolo Padula ,  Caroline Roselyne Dupont ,  Marin Anh-Thuan Demulier ,  Zouaoui Bourezg

IPC分类号： A61J1/10 ,  A61J1/20 ,  A61K33/04 ,  A61K45/06

CPC分类号： A61J1/10 ,  A61K33/04 ,  A61K45/06 ,  A61J1/2048

摘要： The invention relates to a flexible container/multi-chamber container with selective dissolved gas content for stabilizing at least one compound of a medical product having a selective gas requirement for remaining stable, comprising a solution comprising the at least one compound and a fil material from which the container is made that provides for high gas-barrier for the said gas. The at least one compound may be selenium in the form of Se(IV) and is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide. The selective gas may be oxygen, and the headspace of the oxygen maintains the solution to comprise dissolved oxygen (DO) at a level of 0.5 ppm to 8 ppm.

公开(公告)号：US20240238215A1

公开(公告)日：2024-07-18

申请号：US18618465

申请日：2024-03-27

申请人： Peace Out, LLC

发明人： Enrico FREZZA

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/327 ,  A61K31/60 ,  A61K33/04

CPC分类号： A61K9/7007 ,  A61K9/0014 ,  A61K9/7038 ,  A61K31/327 ,  A61K31/60 ,  A61K33/04

摘要： The present technology relates generally to devices for acne treatment, as well as methods for preparing the devices and methods of treatment using the devices. Suitably, the devices comprise a hydrocolloid dressing and an active agent, wherein the amount of the active agent does not reduce the absorption properties of the hydrocolloid dressing. In exemplary embodiments, the active agent is salicylic acid, benzoyl peroxide or sulfur.

公开(公告)号：US20240226141A9

公开(公告)日：2024-07-11

申请号：US18200812

申请日：2023-05-23

申请人： Decibel Therapeutics, Inc.

发明人： John LEE ,  John R. SOGLIA ,  Qi-Ying HU ,  Fuxin SHI

IPC分类号： A61K33/04 ,  A61K9/00 ,  A61P27/16

CPC分类号： A61K33/04 ,  A61K9/0004 ,  A61K9/0046 ,  A61P27/16 ,  A61K47/36

摘要： Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.