公开(公告)号：US20160280623A1

公开(公告)日：2016-09-29

申请号：US15081157

申请日：2016-03-25

Applicant: Brian M. Stoltz ,  Alexander N. Marziale ,  Robert A. Craig ,  Douglas Duquette ,  Kelly E. Kim ,  Marc Liniger ,  Yoshitaka Numajiri

Inventor： Brian M. Stoltz ,  Alexander N. Marziale ,  Robert A. Craig ,  Douglas Duquette ,  Kelly E. Kim ,  Marc Liniger ,  Yoshitaka Numajiri

IPC: C07C45/65 ,  B01J31/04 ,  C07D317/72 ,  C07D211/94 ,  C07D223/10

CPC classification number: C07C45/65 ,  B01J31/04 ,  B01J2231/44 ,  B01J2531/004 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2601/20 ,  C07C2602/10 ,  C07D211/94 ,  C07D223/10 ,  C07D317/72 ,  C07C49/647 ,  C07C49/683

Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.

Abstract translation: 与钯（II）催化剂在烷基化条件下反应。