公开(公告)号：US06671541B2

公开(公告)日：2003-12-30

申请号：US09726358

申请日：2000-12-01

申请人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

发明人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

IPC分类号： A61B600

CPC分类号： A61B5/02755 ,  A61B6/4258 ,  A61B6/507

摘要： A cardiovascular imaging and functional analysis system and method is disclosed, wherein a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis is employed. The cardiovascular imaging and functional analysis system of the present invention can be used as a dedicated nuclear cardiology small field of view imaging camera. The disclosed cardiovascular imaging system and method has the advantages of being able to image physiology, while offering an inexpensive and portable hardware, unlike MRI, CT, and echocardiography systems. The cardiovascular imaging system of the invention employs a basic modular design suitable for cardiac imaging with one of several radionucleide tracers. The detector can be positioned in close proximity to the chest and heart from several different projections, making it possible rapidly to accumulate data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood (MUGA) tests.. In a preferred embodiment, the Cardiovascular Non-Invasive Screening Probe system can perform a novel diagnostic screening test for potential victims of coronary artery disease. The system provides a rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer. Ratios of this activity with the time progression of the injected bolus of radioactive tracer are used to perform diagnosis of the coronary patency (artery disease).

摘要翻译： 公开了一种心血管成像和功能分析系统和方法，其中采用特别适用于心脏成像和功能分析的专用快速，灵敏，紧凑且经济的成像γ照相机系统。 本发明的心血管成像和功能分析系统可用作专用核心脏小视野成像摄像机。 所公开的心血管成像系统和方法具有能够成像生理学的优点，同时提供便宜且便携的硬件，不像MRI，CT和超声心动图系统。本发明的心血管成像系统采用适合于心脏成像的基本模块化设计 与几个放射核素示踪剂之一。 检测器可以从几个不同的投影位置靠近胸部和心脏，使得可以快速地积累数据用于首次分析，正电子成像，定量应激灌注和多门控平衡汇集血液（MUGA）测试。 在优选的实施方案中，心血管非侵入性筛查探针系统可以对冠状动脉疾病的潜在受害者进行新的诊断筛选试验。 该系统通过测量来自注射的放射性示踪剂的丸剂的发射颗粒的活性，提供了冠状动脉阻塞性疾病的快速，便宜的初步指示。 使用注射的放射性示踪剂推注的时间进展的这种活动的比例来执行冠状动脉通畅（动脉疾病）的诊断。

公开(公告)号：US06597940B2

公开(公告)日：2003-07-22

申请号：US09996602

申请日：2001-11-30

申请人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

发明人： Harry Bishop ,  Stanislaw Majewski ,  Marc M. Umeno

IPC分类号： A61B600

CPC分类号： G01T1/1644 ,  A61B5/02755 ,  A61B6/4258 ,  A61B6/507

摘要： One aspect of the present invention relates to screening patients for an early stage of coronary artery disease. According to this method, a patient is screened based on the time-activity curve for a radioactive tracer passing through a left ventricle region of the patient's body. According to another aspect of the invention, an array of gamma particle detectors is employed to obtain data for a region of interest that is larger than and encompasses a left ventricle region of the patient's body. An analysis of the data identifies the subset of the region of interest that corresponds to the left ventricle region. According to a further aspect of the present invention, a second technique is employed to locate the left ventricle region. A still further aspect of the present invention relates to obtaining images of a patient's heart using a high temporal resolution gamma camera.

公开(公告)号：US08017916B1

公开(公告)日：2011-09-13

申请号：US11824357

申请日：2007-06-29

申请人： Stanislaw Majewski ,  Marc M. Umeno

发明人： Stanislaw Majewski ,  Marc M. Umeno

IPC分类号： H01L27/146 ,  G01T1/20

CPC分类号： G01T1/1648 ,  A61B6/4233 ,  A61B6/4241 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/503 ,  A61B6/5205

摘要： A cardiac imaging system employing dual gamma imaging heads co-registered with one another to provide two dynamic simultaneous views of the heart sector of a patient torso. A first gamma imaging head is positioned in a first orientation with respect to the heart sector and a second gamma imaging head is positioned in a second orientation with respect to the heart sector. An adjustment arrangement is capable of adjusting the distance between the separate imaging heads and the angle between the heads. With the angle between the imaging heads set to 180 degrees and operating in a range of 140-159 keV and at a rate of up to 500kHz, the imaging heads are co-registered to produce simultaneous dynamic recording of two stereotactic views of the heart. The use of co-registered imaging heads maximizes the uniformity of detection sensitivity of blood flow in and around the heart over the whole heart volume and minimizes radiation absorption effects. A normalization/image fusion technique is implemented pixel-by-corresponding pixel to increase signal for any cardiac region viewed in two images obtained from the two opposed detector heads for the same time bin. The imaging system is capable of producing enhanced first pass studies, bloodpool studies including planar, gated and non-gated EKG studies, planar EKG perfusion studies, and planar hot spot imaging.

摘要翻译： 使用双伽马成像头的心脏成像系统彼此共同登记以提供病人躯体的心脏部分的两个动态同时视图。 第一伽马成像头相对于心脏扇区被定位在第一方向，并且第二伽马成像头相对于心脏扇区定位在第二方位。 调节装置能够调节分离的成像头之间的距离和头部之间的角度。 由于成像头之间的角度设定为180度并且操作在140-159keV的范围内并且以高达500kHz的速率，成像头被共同配准以产生心脏的两个立体定向视图的同时动态记录。 使用共同注册的成像头使整个心脏体积中的心脏和其周围的血流的检测灵敏度的均匀性最大化并且最小化辐射吸收效应。 一个归一化/图像融合技术通过像素对应的像素来实现，以增加从用于相同时间块的两个相对的检测器头获得的两个图像中观察到的任何心脏区域的信号。 成像系统能够产生增强的一次通过研究，血液研究包括平面，门控和非门控EKG研究，平面EKG灌注研究和平面热点成像。