公开(公告)号：US20100022027A1

公开(公告)日：2010-01-28

申请号：US12499494

申请日：2009-07-08

申请人： Marc-Henry LeBrun ,  Marie-Pascale Latorse

发明人： Marc-Henry LeBrun ,  Marie-Pascale Latorse

IPC分类号： G01N33/566

CPC分类号： C07K14/37

摘要： The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the fungus Magnaporthe grisea with respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

摘要翻译： 本发明涉及水稻致病真菌Magnaporthe grisea的基因组的新型核酸片段，其包含编码蛋白质的基因（以下称为基因763），其存在和完整性对​​于所述真菌与水稻和大麦的发病机制不可或缺 。 本发明还涉及所述基因的启动子，编码蛋白763，蛋白763的基因及其用于鉴定新型杀真菌剂分子的潜在生物学靶标的基因，以及用于分离编码控制真菌Magnaporthe grisea发病机理所必需的生物化学功能的蛋白质的基因 对于大米和大麦。 本发明还涉及抑制与基因763表达有关的真菌发病机理的化合物。