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1.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09266855B2
公开(公告)日：2016-02-23
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： C07D215/20 , A61K31/4709 , C07D401/04 , C07D471/04
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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2.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120077840A1
公开(公告)日：2012-03-29
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： A61K31/4709 , C07D471/04 , A61K31/437 , A61P25/28 , A61P25/18 , A61P27/06 , A61P25/16 , A61P25/02 , A61P27/02 , A61P19/02 , A61K31/4375 , C07D401/04 , A61P29/00
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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3.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09090592B2
公开(公告)日：2015-07-28
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： C07D215/46 , C07D405/14 , C07D401/12 , C07D401/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
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4.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120172376A1
公开(公告)日：2012-07-05
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： A61K31/497 , C07D401/12 , C07D401/14 , A61K31/4709 , A61P25/28 , A61P29/00 , A61P25/18 , A61P25/16 , A61P25/00 , A61P25/02 , A61P27/06 , A61P27/02 , A61P19/02 , C07D471/04 , A61K31/444 , C07D405/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
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5.发明申请USE OF SUBSTITUTED OXINDOLE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF PAIN 审中-公开使用替代的氧化衍生物进行治疗和预防疼痛公开(公告)号：US20110059983A1
公开(公告)日：2011-03-10
申请号：US12797385
申请日：2010-06-09
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/14 , A61P29/00
CPC分类号： A61K31/404
摘要： The present invention relates to the use of substituted oxindole derivatives of formula I as defined in the claims and description for the treatment or prophylaxis of pain.
摘要翻译： 本发明涉及如权利要求和说明书所定义的式I的取代羟吲哚衍生物在治疗或预防疼痛中的应用。
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