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1.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09090592B2
公开(公告)日：2015-07-28
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： C07D215/46 , C07D405/14 , C07D401/12 , C07D401/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
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2.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120172376A1
公开(公告)日：2012-07-05
申请号：US13339884
申请日：2011-12-29
申请人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
发明人： Sean Colm Turner , Helmut Mack , Margaretha Henrica Maria Bakker , Marcel van Gaalen , Carolin Hoft , Wilfried Hornberger
IPC分类号： A61K31/497 , C07D401/12 , C07D401/14 , A61K31/4709 , A61P25/28 , A61P29/00 , A61P25/18 , A61P25/16 , A61P25/00 , A61P25/02 , A61P27/06 , A61P27/02 , A61P19/02 , C07D471/04 , A61K31/444 , C07D405/14
CPC分类号： C07D471/04 , A61P25/16 , A61P25/28 , C07D215/46 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.
摘要翻译： 本发明涉及式I的新型杂环化合物，其中变量如权利要求或描述中所定义，其可用于抑制糖原合酶激酶3（GSK-3），含有该化合物的组合物，其用于制备药物的用途 用于治疗易于用调节，优选抑制糖原合酶激酶3和bgr的活性的化合物治疗的医学疾病;以及治疗易于用调节糖原合酶激酶3和bgr的化合物治疗的医学病症的方法; 使用化合物的活性。
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3.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US09266855B2
公开(公告)日：2016-02-23
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： C07D215/20 , A61K31/4709 , C07D401/04 , C07D471/04
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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4.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20120077840A1
公开(公告)日：2012-03-29
申请号：US13245123
申请日：2011-09-26
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Marcel Van Gaalen , Falko Ernst Wolter , Wilfried Hornberger , Marjoleen Nijsen
IPC分类号： A61K31/4709 , C07D471/04 , A61K31/437 , A61P25/28 , A61P25/18 , A61P27/06 , A61P25/16 , A61P25/02 , A61P27/02 , A61P19/02 , A61K31/4375 , C07D401/04 , A61P29/00
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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5.发明授权Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors 有权杂环化合物及其作为糖原合酶激酶-3抑制剂的用途公开(公告)号：US08318793B2
公开(公告)日：2012-11-27
申请号：US12748875
申请日：2010-03-29
IPC分类号： A61K31/40 , C07D209/34 , C07D295/00
CPC分类号： C07D401/04 , C07D491/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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6.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE-3抑制剂的用途公开(公告)号：US20110003810A1
公开(公告)日：2011-01-06
申请号：US12748875
申请日：2010-03-29
IPC分类号： A61K31/5377 , C07D491/04 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P25/18 , A61P25/28 , A61P25/16 , A61P27/06 , A61P19/02 , A61P25/02 , A61P25/00 , A61P9/00 , A61P29/00
CPC分类号： C07D401/04 , C07D491/04
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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![1-(7-(hexahydropyrrolo [3,4-c] pyrrol-2 (1H)-yl) quinolin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3)](/abs-image/US/2013/06/04/US08455648B2/abs.jpg.150x150.jpg)
7.发明授权1-(7-(hexahydropyrrolo [3,4-c] pyrrol-2 (1H)-yl) quinolin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3) 有权1-（7-（六氢吡咯并[3,4-c]吡咯-2（1H） - 基）喹啉-4-基）-3-（吡嗪-2-基）脲衍生物和相关化合物作为糖原合酶激酶3 GSK-3）公开(公告)号：US08455648B2
公开(公告)日：2013-06-04
申请号：US12988833
申请日：2009-04-24
IPC分类号： C07D215/38
CPC分类号： C07D487/04 , C07D487/08 , C07D491/048
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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![1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3)](/abs-image/US/2011/05/05/US20110105528A1/abs.jpg.150x150.jpg)
8.发明申请1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3) 有权1-（7-（六氢吡喃并[3,4-C]吡咯-2（1H） - 基）喹啉-4-基）-3-（吡嗪-2-基）脲衍生物和相关化合物作为GLYCOGEN SYNTHASE KINASE 3（ GSK-3）公开(公告)号：US20110105528A1
公开(公告)日：2011-05-05
申请号：US12988833
申请日：2009-04-24
IPC分类号： A61K31/497 , C07D403/14 , C07D405/14 , A61K31/4709 , A61P25/18 , A61P25/28 , A61P25/16 , A61P19/02
CPC分类号： C07D487/04 , C07D487/08 , C07D491/048
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。
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9.发明申请HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS 有权杂环化合物及其作为GLYCOGEN SYNTHASE KINASE 3抑制剂的用途公开(公告)号：US20100324042A1
公开(公告)日：2010-12-23
申请号：US12446233
申请日：2007-10-19
IPC分类号： A61K31/497 , C07D401/12 , C07D241/20 , C07D413/14 , C07D471/04 , A61K31/4965 , A61K31/5377 , A61K31/4709 , A61P25/28
CPC分类号： C07D401/12 , C07D241/20 , C07D413/14 , C07D471/04
摘要： The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3),
摘要翻译： 本发明涉及通式（I）的杂环化合物及其用途和制备方法，制备该化合物的方法，含有至少一种所述化合物的组合物和使用至少一种化合物的治疗方法。 特别地，通式（I）的化合物可用于抑制糖原合成酶激酶3（GSK-3），
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10.发明授权Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor 有权适用于治疗对血清素5HT6受体的调节作用的病症的杂环化合物公开(公告)号：US08497273B2
公开(公告)日：2013-07-30
申请号：US12297328
申请日：2007-04-18
申请人： Roland Grandel , Wilfried Martin Braje , Andreas Haupt , Sean Colm Turner , Udo Lange , Karla Drescher , Liliane Unger
发明人： Roland Grandel , Wilfried Martin Braje , Andreas Haupt , Sean Colm Turner , Udo Lange , Karla Drescher , Liliane Unger
IPC分类号： A61K31/496 , C07D401/04 , C07D401/14 , A61K31/4439 , A61K31/4545 , C07D413/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The invention relates to compounds of the formula (I) wherein the variables have meanings given in the claims and the description. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a 5HT6 receptor ligand.
摘要翻译： 本发明涉及式（I）化合物，其中变量具有权利要求书和说明书中给出的含义。 本发明还涉及式I化合物或其药学上可接受的盐在制备用于治疗易受5HT6受体配体治疗的医学病症的药物中的用途。
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