公开(公告)号：US09677052B2

公开(公告)日：2017-06-13

申请号：US14707718

申请日：2015-05-08

申请人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne ,  Matthew Lebar ,  Dorothee Andres

发明人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne ,  Matthew Lebar ,  Dorothee Andres

IPC分类号： C12N9/00 ,  C07H13/06 ,  C12P21/00 ,  A61K39/39 ,  C07H15/04 ,  C07K4/00 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/55583 ,  A61K2039/55594 ,  C07H13/06 ,  C07H15/04 ,  C07K4/00 ,  C12N9/00 ,  C12N9/93 ,  C12N15/04 ,  C12P21/005

摘要： The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.

公开(公告)号：US20150320857A1

公开(公告)日：2015-11-12

申请号：US14707718

申请日：2015-05-08

申请人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne

发明人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne

IPC分类号： A61K39/39 ,  C07H13/06 ,  C12N9/00

CPC分类号： A61K39/39 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/55583 ,  A61K2039/55594 ,  C07H13/06 ,  C07H15/04 ,  C07K4/00 ,  C12N9/00 ,  C12N9/93 ,  C12N15/04 ,  C12P21/005

摘要： The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.

摘要翻译： 本公开一般涉及细菌的遗传工程。 更具体地，本公开描述了大肠杆菌的基因工程以产生突变的O-抗原连接酶，以及由该基因工程产生的新的脂多糖分子。 还描述了使用这些新型分子的方法。