专利检索 ap:("Thomas J. Silhavy" OR "Marcin Grabowicz" OR "Daniel Kahne" OR "Matthew Lebar" OR "Dorothee Andres") AND inv:"Dorothee Andres" 第 1 页

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发明授权
Modified lipopolysaccharide glycoform and method of use 有权

公开(公告)号：US09677052B2

公开(公告)日：2017-06-13

申请号：US14707718

申请日：2015-05-08

申请人： Thomas J. Silhavy , Marcin Grabowicz , Daniel Kahne , Matthew Lebar , Dorothee Andres

发明人： Thomas J. Silhavy , Marcin Grabowicz , Daniel Kahne , Matthew Lebar , Dorothee Andres

IPC分类号： C12N9/00 , C07H13/06 , C12P21/00 , A61K39/39 , C07H15/04 , C07K4/00 , A61K39/00

CPC分类号： A61K39/39 , A61K2039/55516 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07H13/06 , C07H15/04 , C07K4/00 , C12N9/00 , C12N9/93 , C12N15/04 , C12P21/005

摘要： The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.