公开(公告)号：US20080147382A1

公开(公告)日：2008-06-19

申请号：US11471913

申请日：2006-06-20

申请人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

发明人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

IPC分类号： G06F17/21

CPC分类号： G06F17/2785

摘要： A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

摘要翻译： 提供了根据本发明的示例性实施例的方法，系统和软件布置，以从用本体论控制的词汇增加的数值实验数据中提取描述叙述。 这种系统，方法和软件安排的一个示例性应用是根据生物过程来组织基因表达时程过程数据，当生物系统响应于其正常或扰动的环境时，可以被激活和去激活。 本发明还可以具有药物或疫苗发现的生物学应用，了解改变的疾病状态（例如，癌症，神经变性或自身免疫疾病等）中的细胞的行为，遗传修饰天然野生型 - 类型生物，基因工程等。其他示例性应用可以包括理解在互联网上互动的用户群体的神经行为，市场行为等。

公开(公告)号：US20060155483A1

公开(公告)日：2006-07-13

申请号：US10432766

申请日：2001-09-28

申请人： Marco Antoniotti ,  Bhubaneswar Mishra ,  Thomas Anantharaman ,  Salvatore Paxia ,  David Schwartz

发明人： Marco Antoniotti ,  Bhubaneswar Mishra ,  Thomas Anantharaman ,  Salvatore Paxia ,  David Schwartz

IPC分类号： G06F19/00

CPC分类号： G06F19/22

摘要： A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map and/or the second DNA map. In particular, the first and second DNA maps can be received (the first DNA map corresponding to a sequence DNA map, and the second DNA map corresponding to a genomic consensus DNA map as provided in an optical DNA map). Then, the accuracy of the first DNA map and/or the second DNA map is validated based on information associated with the first and second DNA maps. In addition, a method and system are provided for aligning a plurality of DNA sequences with a ordered DNA restriction map. The DNA sequences and the DNA map are received (the DNA sequences being fragments of a genome and the DNA map corresponding to a genomic consensus DNA map which relates to an optical ordered DNA map). Then, a level of accuracy of the DNA sequences and the DNA map is obtained based on information associated with the DNA sequences and the DNA map by means of the method and system described above. The locations of the DNA map at which the DNA sequences are capable of being associated with particular segments of the DNA map are located. Furthermore, it is possible to obtain locations of the DNA map (without the validation) by locating an optimal one of the locations for each of the DNA sequences for each of the locations.

摘要翻译： 提供了一种方法和系统，用于将第一DNA限制性图谱的有序区段与第二DNA限制图谱的有序区段进行比较，以确定第一DNA图谱和/或第二DNA图谱的准确度。 特别地，可以接收第一个和第二个DNA图谱（对应于序列DNA图谱的第一个DNA图谱，和对应于光学DNA图谱中提供的基因组共有DNA图谱的第二个DNA图谱）。 然后，基于与第一和第二DNA图相关联的信息来验证第一DNA图和/或第二DNA图的准确性。 此外，提供了用于使多个DNA序列与有序DNA限制图对齐的方法和系统。 接受DNA序列和DNA图谱（DNA序列是基因组的片段，DNA图谱对应于涉及光学有序DNA图谱的基因组共有DNA图谱）。 然后，通过上述方法和系统，基于与DNA序列和DNA图谱相关的信息，获得DNA序列和DNA图谱的准确度。 DNA序列的DNA图谱位置可以与DNA图谱的特定片段相关联。 此外，通过为每个位置定位每个DNA序列的最佳位置之一，可以获得DNA图谱的位置（无需验证）。

公开(公告)号：US08628611B2

公开(公告)日：2014-01-14

申请号：US13582918

申请日：2011-03-03

申请人： Stefano Crespi ,  Marco Antoniotti ,  Giuseppe Li Bassi ,  Giovanni Floridi

发明人： Stefano Crespi ,  Marco Antoniotti ,  Giuseppe Li Bassi ,  Giovanni Floridi

IPC分类号： C04B41/50 ,  C04B41/86

CPC分类号： C09C1/42 ,  C01P2004/60 ,  C01P2006/22 ,  C04B41/009 ,  C04B41/5022 ,  C04B41/86 ,  Y10T428/31971 ,  C04B33/00 ,  C04B41/4539 ,  C04B2103/0079

摘要： The present invention relates to a rheology modifier for ceramic glazes comprising a water-swellable granulated clay, a carboxymethyl cellulose and possibly another natural gum. In another aspect the invention relates to the ceramic glaze and the glaze slip obtained using the above rheology modifier, which can be used for glazing green or fired ceramic bodies such as artware, tableware, tile, heavy clays products and sanitaryware.

摘要翻译： 本发明涉及一种用于陶瓷釉料的流变改性剂，其包含水溶胀性颗粒状粘土，羧甲基纤维素和可能另外的天然胶。 在另一方面，本发明涉及使用上述流变改性剂获得的陶瓷釉料和釉料，其可用于玻璃窗或烧制陶瓷体如炊具，餐具，瓷砖，重粘土产品和卫生洁具。

公开(公告)号：US08572018B2

公开(公告)日：2013-10-29

申请号：US12803195

申请日：2010-06-21

申请人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

发明人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

IPC分类号： G06F17/00 ,  G06N7/00 ,  G06N7/08

CPC分类号： G06N5/048 ,  G06F17/2785

摘要： A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

摘要翻译： 提供了根据本发明的示例性实施例的方法，系统和软件布置，以从用本体论控制的词汇增加的数值实验数据中提取描述叙述。 这种系统，方法和软件安排的一个示例性应用是根据生物过程来组织基因表达时程过程数据，当生物系统响应于其正常或扰动的环境时，可以被激活和去激活。 本发明还可以具有药物或疫苗发现的生物学应用，了解改变的疾病状态（例如，癌症，神经变性或自身免疫疾病等）中的细胞的行为，遗传修饰天然野生型 - 类型生物，基因工程等。其他示例性应用可以包括理解在互联网上互动的用户群体的神经行为，市场行为等。

公开(公告)号：US20130150229A1

公开(公告)日：2013-06-13

申请号：US13582918

申请日：2011-03-03

申请人： Stefano Crespi ,  Marco Antoniotti ,  Giuseppe Li Bassi ,  Giovanni Floridi

发明人： Stefano Crespi ,  Marco Antoniotti ,  Giuseppe Li Bassi ,  Giovanni Floridi

IPC分类号： C09C1/42

CPC分类号： C09C1/42 ,  C01P2004/60 ,  C01P2006/22 ,  C04B41/009 ,  C04B41/5022 ,  C04B41/86 ,  Y10T428/31971 ,  C04B33/00 ,  C04B41/4539 ,  C04B2103/0079

摘要： The present invention relates to a theology modifier for ceramic glazes comprising a water-swellable granulated clay, a carboxymethyl cellulose and possibly another natural gum. In another aspect the invention relates to the ceramic glaze and the glaze slip obtained using the above rheology modifier, which can be used for glazing green or fired ceramic bodies such as artware, tableware, tile, heavy clays products and sanitaryware.

摘要翻译： 本发明涉及一种用于陶瓷釉料的神经改性剂，其包含水溶胀性粒状粘土，羧甲基纤维素和可能另外的天然树胶。 在另一方面，本发明涉及使用上述流变改性剂获得的陶瓷釉料和釉料，其可用于玻璃窗或烧制陶瓷体如炊具，餐具，瓷砖，重粘土产品和卫生洁具。

公开(公告)号：US20140052686A1

公开(公告)日：2014-02-20

申请号：US14064778

申请日：2013-10-28

申请人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

发明人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

IPC分类号： G06N5/04

CPC分类号： G06N5/048 ,  G06F17/2785

摘要： A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

摘要翻译： 提供了根据本发明的示例性实施例的方法，系统和软件布置，以从用本体论控制的词汇增加的数值实验数据中提取描述叙述。 这种系统，方法和软件安排的一个示例性应用是根据生物过程来组织基因表达时程过程数据，当生物系统响应于其正常或扰动的环境时，可以被激活和去激活。 本发明还可以具有药物或疫苗发现的生物学应用，了解改变的疾病状态（例如，癌症，神经变性或自身免疫疾病等）中的细胞的行为，遗传修饰天然野生型 - 类型生物，基因工程等。其他示例性应用可以包括理解在互联网上互动的用户群体的神经行为，市场行为等。

公开(公告)号：US20110119221A1

公开(公告)日：2011-05-19

申请号：US12803195

申请日：2010-06-21

申请人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

发明人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

IPC分类号： G06N5/02

CPC分类号： G06N5/048 ,  G06F17/2785

摘要： A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

摘要翻译： 提供了根据本发明的示例性实施例的方法，系统和软件布置，以从用本体论控制的词汇增加的数值实验数据中提取描述叙述。 这种系统，方法和软件安排的一个示例性应用是根据生物过程来组织基因表达时程过程数据，当生物系统响应于其正常或扰动的环境时，可以被激活和去激活。 本发明还可以具有药物或疫苗发现的生物学应用，了解改变的疾病状态（例如，癌症，神经变性或自身免疫疾病等）中的细胞的行为，遗传修饰天然野生型 - 类型生物，基因工程等。其他示例性应用可以包括理解在互联网上互动的用户群体的神经行为，市场行为等。

公开(公告)号：US07831392B2

公开(公告)日：2010-11-09

申请号：US10432766

申请日：2001-09-28

申请人： Marco Antoniotti ,  Bhubaneswar Mishra ,  Thomas Anantharaman ,  Salvatore Paxia ,  David C. Schwartz

发明人： Marco Antoniotti ,  Bhubaneswar Mishra ,  Thomas Anantharaman ,  Salvatore Paxia ,  David C. Schwartz

IPC分类号： G01N33/48 ,  C12Q1/68

CPC分类号： G06F19/22

摘要： A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map and/or the second DNA map. In particular, the first and second DNA maps can be received (the first DNA map corresponding to a sequence DNA map, and the second DNA map corresponding to a genomic consensus DNA map as provided in an optical DNA map). Then, the accuracy of the first DNA map and/or the second DNA map is validated based on information associated with the first and second DNA maps. In addition, a method and system are provided for aligning a plurality of DNA sequences with a ordered DNA restriction map. The DNA sequences and the DNA map are received (the DNA sequences being fragments of a genome and the DNA map corresponding to a genomic consensus DNA map which relates to an optical ordered DNA map). Then, a level of accuracy of the DNA sequences and the DNA map is obtained based on information associated with the DNA sequences and the DNA map by means of the method and system described above. The locations of the DNA map at which the DNA sequences are capable of being associated with particular segments of the DNA map are located. Furthermore, it is possible to obtain locations of the DNA map (without the validation) by locating an optimal one of the locations for each of the DNA sequences for each of the locations.

摘要翻译： 提供了一种方法和系统，用于将第一DNA限制性图谱的有序区段与第二DNA限制图谱的有序区段进行比较，以确定第一DNA图谱和/或第二DNA图谱的准确度。 特别地，可以接收第一个和第二个DNA图谱（对应于序列DNA图谱的第一个DNA图谱，和对应于光学DNA图谱中提供的基因组共有DNA图谱的第二个DNA图谱）。 然后，基于与第一和第二DNA图相关联的信息来验证第一DNA图和/或第二DNA图的准确性。 此外，提供了用于使多个DNA序列与有序DNA限制图对齐的方法和系统。 接受DNA序列和DNA图谱（DNA序列是基因组的片段，DNA图谱对应于涉及光学有序DNA图谱的基因组共有DNA图谱）。 然后，通过上述方法和系统，基于与DNA序列和DNA图谱相关的信息，获得DNA序列和DNA图谱的准确度。 DNA序列的DNA图谱位置可以与DNA图谱的特定片段相关联。 此外，通过为每个位置定位每个DNA序列的最佳位置之一，可以获得DNA图谱的位置（无需验证）。

公开(公告)号：US07801841B2

公开(公告)日：2010-09-21

申请号：US11471913

申请日：2006-06-20

申请人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

发明人： Bhubaneswar Mishra ,  Marco Antoniotti ,  Naren Ramakrishnan

IPC分类号： G06N7/00

CPC分类号： G06F17/2785

摘要： A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

摘要翻译： 提供了根据本发明的示例性实施例的方法，系统和软件布置，以从用本体论控制的词汇增加的数值实验数据中提取描述叙述。 这种系统，方法和软件安排的一个示例性应用是根据生物过程来组织基因表达时程过程数据，当生物系统响应于其正常或扰动的环境时，可以被激活和去激活。 本发明还可以具有药物或疫苗发现的生物学应用，了解改变的疾病状态（例如，癌症，神经变性或自身免疫疾病等）中的细胞的行为，遗传修饰天然野生型 - 类型生物，基因工程等。其他示例性应用可以包括理解在互联网上互动的用户群体的神经行为，市场行为等。