公开(公告)号：US20070020623A1

公开(公告)日：2007-01-25

申请号：US10250691

申请日：2001-12-20

申请人： Dirk Petersohn ,  Marcus Conradt ,  Kay Hoffmann

发明人： Dirk Petersohn ,  Marcus Conradt ,  Kay Hoffmann

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/158

摘要： Described herein are processes and devices useful for the identification of genes differentially expressed in skin. Preferably, the processes and devices are useful for the in vitro determination of skin homeostasis. Also described is a combination having a plurality of genes differentially expressed in skin compared to other tissues. Biochips and test kits useful in processes for the identification of genes expressed in skin homeostasis as well as in processes for screening substances useful in maintaining or promoting homeostasis of the skin are also described. Also described are processes for identifying substances useful in maintaining or promoting homeostasis of the skin as well as processes for making cosmetic and/or pharmaceutical preparations comprising such substances.

摘要翻译： 本文描述了可用于鉴定在皮肤中差异表达的基因的方法和装置。 优选地，所述方法和装置可用于体外测定皮肤内稳态。 还描述了与其他组织相比，在皮肤中具有差异表达的多种基因的组合。 还描述了可用于鉴定在皮肤内稳态中表达的基因的方法中的生物芯片和测试试剂盒，以及用于筛选可用于维持或促进皮肤的体内平衡的物质的方法。 还描述了用于鉴定可用于维持或促进皮肤的体内平衡的物质的方法以及制备包含这些物质的化妆品和/或药物制剂的方法。

公开(公告)号：US20060088852A1

公开(公告)日：2006-04-27

申请号：US11158209

申请日：2005-06-20

申请人： Dirk Petersohn ,  Kordula Schlotmann ,  Thomas Gassenmeier ,  Olaf Holtkoetter ,  Marcus Conradt ,  Kay Hofmann

发明人： Dirk Petersohn ,  Kordula Schlotmann ,  Thomas Gassenmeier ,  Olaf Holtkoetter ,  Marcus Conradt ,  Kay Hofmann

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158

摘要： The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating hairy skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating hairy skin and to a method for producing a cosmetic or pharmaceutical preparation for treating hairy skin.

摘要翻译： 本发明涉及一种用于确定体外毛皮的体内平衡的方法，以及用于测定用于确定毛皮皮肤标记物的试剂盒和生物芯片，以及使用蛋白质，mRNA分子或其片段作为毛皮皮肤的标记物。 本发明还涉及用于检测用于治疗毛皮的化妆品或药物活性物质的有效性的试验方法，以及用于鉴定用于治疗毛发皮肤的化妆品或药物活性物质的筛选方法以及化妆品或药物制剂的制备方法 用于治疗毛皮。