公开(公告)号：US07371537B2

公开(公告)日：2008-05-13

申请号：US11116725

申请日：2005-04-27

申请人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

发明人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

IPC分类号： C02K1/00 ,  G01N33/53

CPC分类号： C12Q1/42 ,  C07K14/4716 ,  G01N33/5052 ,  G01N33/9493

摘要： The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

摘要翻译： 本发明提供用于调节B-淋巴细胞活化的组合物和方法。 提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。

公开(公告)号：US06929923B2

公开(公告)日：2005-08-16

申请号：US10202480

申请日：2002-07-23

申请人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

发明人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

IPC分类号： C07K14/705 ,  G01N33/68 ,  C12Q1/02

CPC分类号： G01N33/6872 ,  C07K14/705 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

摘要翻译： 本发明提供了调节白细胞活化的组合物和方法。 提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

公开(公告)号：US06890725B2

公开(公告)日：2005-05-10

申请号：US10202481

申请日：2002-07-23

申请人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

发明人： Marcy K. Vallone ,  Brian R. Wong ,  Esteban Masuda ,  Mark Powell

IPC分类号： C07K14/47 ,  C12Q1/42 ,  G01N33/50 ,  G01N33/94 ,  G01N33/53

CPC分类号： C12Q1/42 ,  C07K14/4716 ,  G01N33/5052 ,  G01N33/9493

摘要： The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

摘要翻译： 本发明提供用于调节B-淋巴细胞活化的组合物和方法。 提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。 还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。