公开(公告)号：US09867811B2

公开(公告)日：2018-01-16

申请号：US14128877

申请日：2012-07-06

申请人： Yoshie Arai ,  Margaret Elizabeth Brousseau ,  Jessie Gu ,  Tomoko Hayashi ,  Hironobu Mitani ,  Muneto Mogi ,  Kazuhiko Nonomura ,  Ken Yamada

发明人： Yoshie Arai ,  Margaret Elizabeth Brousseau ,  Jessie Gu ,  Tomoko Hayashi ,  Hironobu Mitani ,  Muneto Mogi ,  Kazuhiko Nonomura ,  Ken Yamada

IPC分类号： A61K31/421 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/55 ,  A61K31/505 ,  A61K31/5377 ,  A61K45/06

CPC分类号： A61K31/421 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06

摘要： The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R1, X1, R7, R5, C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.