公开(公告)号：US4556563A

公开(公告)日：1985-12-03

申请号：US474750

申请日：1983-03-10

申请人： Marianna Pongor nee Csakvari ,  Gabor Nagy ,  Gabor Horvath ,  Maria David nee Kenez ,  Sandor Bozsoky ,  Sandor Virag ,  Katalin Marmarosi nee Kellner

发明人： Marianna Pongor nee Csakvari ,  Gabor Nagy ,  Gabor Horvath ,  Maria David nee Kenez ,  Sandor Bozsoky ,  Sandor Virag ,  Katalin Marmarosi nee Kellner

IPC分类号： A61K31/40 ,  A61K31/505 ,  A61P29/00 ,  A61K31/60

CPC分类号： A61K31/505 ,  Y10S514/96 ,  Y10S514/966

摘要： The invention relates to synergistic antiphlogistic pharmaceutical compositions comprising a pyrido [1,2-a]-pyrimidine derivative of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 stands for lower alkoxycarbonyl or carbamoyl and the dotted line represents an optionally hydrogenated band or a salt or quaternary salt thereof and 1-[p-chloro-benzoly]-2-methyl-5-methoxy-indolyl-3-acetic acid of the Formula II ##STR2## The advantage of the compositions is that as a result of the synergistic activity of the compound of the Formula I, the antiphlogistic Indomethacin of the Formula II can be administered in a significantly lower doses and consequently the unfavorable side effects of the latter compound are mitigated.

摘要翻译： 本发明涉及包含式I的吡啶并[1,2-a] - 嘧啶衍生物（I）的协同消炎药物组合物，其中R1和R2是低级烷基，R3代表低级烷氧基羰基或氨基甲酰基，虚线 代表任选氢化的带或其盐或季盐和式II的1- [对氯 - 苯并[2-氯苯基] -2-甲基-5-甲氧基 - 吲哚基-3-乙酸。（II） 组合物是由于式I化合物的协同作用的结果，可以以显着较低的剂量施用式II的消炎药吲哚美辛，从而减轻后一种化合物的不良副作用。