公开(公告)号：US06631283B2

公开(公告)日：2003-10-07

申请号：US09894896

申请日：2001-06-29

申请人： Brian Storrie ,  Maria Tarrago-Trani ,  Sam English

发明人： Brian Storrie ,  Maria Tarrago-Trani ,  Sam English

IPC分类号： A61B505

CPC分类号： A61K41/0057 ,  A61K41/0071 ,  A61K47/6415 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/085 ,  A61K49/14

摘要： The invention provides compositions and methods for use in delivering a substance of interest to a targeted cell. The substance of interest is associated with a targeting fragment of a toxin molecule or a lectin that specifically binds to a cell surface receptor, such as the B subunit of an A/B type toxin molecule. The substance of interest may be a photosensitizing agent, in which case the cell (e.g. a cancer cell) may be killed by exposure to light after delivery of the agent. Alternatively, the substance of interest may be a visualizing agent that enhances visualization of the targeted cell.