公开(公告)号：US07422757B2

公开(公告)日：2008-09-09

申请号：US10501873

申请日：2003-01-21

申请人： Jari Alander ,  Staffan Norberg ,  Henri Hansson ,  Marianne Svärd ,  Lars Hovgaard

发明人： Jari Alander ,  Staffan Norberg ,  Henri Hansson ,  Marianne Svärd ,  Lars Hovgaard

IPC分类号： B29C43/02 ,  B29B9/00

CPC分类号： A61K9/1617 ,  A61K9/1075 ,  A61K9/1274 ,  A61K9/1694 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027

摘要： The invention refers to a process for the preparation of a self-dispersing or self-emulsifying tablet, wherein a heated granulation mixture containing an active lipophilic substance and a surfactant is granulated into granules, said granules are cooled to a semi-solid state, said semi-solid granules are mixed with one or more fillers to cover the surface of the granules, distribution, the sieved granules are mixed with tabletting aids, and said mixture is compressed into tablets. The granulation mixture can also contain a lipid and/or filler. The invention also refers to tablets prepared by said processes.

摘要翻译： 本发明涉及一种制备自分散或自乳化片剂的方法，其中将含有活性亲脂性物质和表面活性剂的加热的造粒混合物造粒成颗粒，将所述颗粒冷却至半固体状态，所述 将半固体颗粒与一种或多种填料混合以覆盖颗粒的表面，分布，将筛分的颗粒与压片助剂混合，并将所述混合物压制成片剂。 造粒混合物还可以含有脂质和/或填料。 本发明还涉及通过所述方法制备的片剂。