公开(公告)号：US20100160382A1

公开(公告)日：2010-06-24

申请号：US12643095

申请日：2009-12-21

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K31/4439 ,  A61P1/04

CPC分类号： A61K9/0095 ,  A61K9/16 ,  A61K31/4439 ,  A61K33/00

摘要： An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the composition includes sodium alginate; an anti-acid soluble agent or a combination of anti-acids; an inhibitor of proton pump; diluent and sweetening agents, wherein a) at least 30% of sodium alginate present in the formulation along with the total of the inhibitor of proton pump are homogeneously distributed over the surface of the total soluble anti-acid agent [or] of the combination of anti-acids of the composition; and b) the rest, about 70%, of sodium alginate present in the formulation contains a percentage of humidity of less than 2%.

摘要翻译： 一种抗酸药物组合物，用于通过粉末形式的粘膜保护活性快速和长时间地中和胃酸，通过在水中分散以制备用于口服的药物溶液或悬浮液，其特征在于该组合物包括藻酸钠; 抗酸可溶剂或抗酸组合; 质子泵抑制剂; 稀释剂和甜味剂，其中a）制剂中存在的至少30％的海藻酸钠以及质子泵抑制剂的总量均匀分布在总可溶性抗酸剂[或]的组合的表面上 抗酸成分; 和b）制剂中存在的海藻酸钠的其余约70％含有小于2％的湿度百分比。

公开(公告)号：US20150072000A1

公开(公告)日：2015-03-12

申请号：US14386377

申请日：2012-03-20

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K9/50 ,  A61K9/20 ,  A61K31/4439 ,  A61K9/14 ,  A61K31/196 ,  A61K47/36

CPC分类号： A61K9/5036 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2081 ,  A61K9/5084 ,  A61K9/5089 ,  A61K31/196 ,  A61K31/4439 ,  A61K47/36 ,  A61K2300/00

摘要： Method for producing enteric microcapsules without coating, containing diclofenac or one of the salts thereof with satisfactory anti-inflammatory activity and low gastric aggressiveness; and a pharmaceutical composition containing them. The method comprises a) preparing a mixture in water-ethanol with an alginate salt, adding diclofenac or one of the salts thereof previously diluted with a surfactant and sodium bicarbonate; b) adding the previous solution to a solution with a calcium salt; c) resuspending the microcapsules obtained and isolated in an aqueous solution of the alginate salt; and d) isolating, drying and sieving through 1000 and 250 micron meshes the microcapsules obtained; and selecting the fraction comprised between both meshes. The pharmaceutical composition can be an oral composition, tablets, chewable tablets, or a powder for suspension in water.

摘要翻译： 无涂层生产肠溶微胶囊的方法，含有双氯芬酸或其盐之一，具有令人满意的抗炎活性和低胃侵蚀性; 和含有它们的药物组合物。 该方法包括：a）用海藻酸盐在水 - 乙醇中制备混合物，加入预先用表面活性剂和碳酸氢钠稀释的双氯芬酸或其中一种盐; b）将以前的溶液加入到含有钙盐的溶液中; c）将获得并分离的微胶囊重悬于藻酸盐水溶液中; 和d）通过1000和250微米网眼分离，干燥和筛分获得的微胶囊; 并选择两个网格之间的分数。 药物组合物可以是口服组合物，片剂，咀嚼片或悬浮于水中的粉末。

公开(公告)号：US08685449B2

公开(公告)日：2014-04-01

申请号：US13576606

申请日：2010-02-01

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K9/44

CPC分类号： A61K9/145 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/282 ,  A61K9/286 ,  A61K9/5084 ,  A61K31/365

摘要： Pharmaceutical compositions with anti-obesity activity that act peripherally are provided, which comprise a premixture made up of pure orlistat as the active ingredient and other components that afford the premixture stability and suitable physical properties for simply preparing compositions for oral use with convenient dosage flexibility; and optionally necessary thickening, flavouring and colouring agents. A method for preparing said compositions is also provided. The orlistat content in the premixture is less than 20% of the total weight of the mass, preferably between 12 and 17%.The pharmaceutical composition can be formulated indistinctively from the premixture both as grooved tablets and powder for suspension.

摘要翻译： 提供了具有外周作用的具有抗肥胖活性的药物组合物，其包含由纯奥利司他作为活性成分制成的预混合物和提供预混合物稳定性和合适的物理性质的简单制备用于口服使用的组合物的方便剂量灵活性的预混剂; 和任选需要的增稠剂，调味剂和着色剂。 还提供了制备所述组合物的方法。 预混物中的奥利司他含量小于质量总重量的20％，优选在12至17％之间。 药物组合物可以与预混合物不同的形式配制成凹槽片剂和用于悬浮的粉末。

公开(公告)号：US08093271B2

公开(公告)日：2012-01-10

申请号：US12643095

申请日：2009-12-21

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K31/4439 ,  A61P1/04

CPC分类号： A61K9/0095 ,  A61K9/16 ,  A61K31/4439 ,  A61K33/00

摘要： An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the composition includes sodium alginate; an anti-acid soluble agent or a combination of anti-acids; an inhibitor of proton pump; diluent and sweetening agents, wherein a) at least 30% of sodium alginate present in the formulation along with the total of the inhibitor of proton pump are homogeneously distributed over the surface of the total soluble anti-acid agent of the combination of anti-acids of the composition; and b) the rest, about 70%, of sodium alginate present in the formulation contains a percentage of humidity of less than 2%.

摘要翻译： 一种抗酸药物组合物，用于通过粉末形式的粘膜保护活性快速和长时间地中和胃酸，通过在水中分散以制备用于口服的药物溶液或悬浮液，其特征在于该组合物包括藻酸钠; 抗酸可溶剂或抗酸组合; 质子泵抑制剂; 稀释剂和甜味剂，其中a）制剂中存在的至少30％的藻酸钠与质子泵抑制剂的总量一起均匀分布在抗酸组合的总可溶性抗酸剂的表面上 的组成; 和b）制剂中存在的海藻酸钠的其余约70％含有小于2％的湿度百分比。

公开(公告)号：US09668978B2

公开(公告)日：2017-06-06

申请号：US14386377

申请日：2012-03-20

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K9/20 ,  A61K9/50 ,  A61K9/16 ,  A61K31/196 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K31/44 ,  A61K31/4439 ,  A61K47/36

CPC分类号： A61K9/5036 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2081 ,  A61K9/5084 ,  A61K9/5089 ,  A61K31/196 ,  A61K31/4439 ,  A61K47/36 ,  A61K2300/00

摘要： Method for producing enteric microcapsules without coating, containing diclofenac or one of the salts thereof with satisfactory anti-inflammatory activity and low gastric aggressiveness; and a pharmaceutical composition containing them. The method comprises a) preparing a mixture in water-ethanol with an alginate salt, adding diclofenac or one of the salts thereof previously diluted with a surfactant and sodium bicarbonate; b) adding the previous solution to a solution with a calcium salt; c) resuspending the microcapsules obtained and isolated in an aqueous solution of the alginate salt; and d) isolating, drying and sieving through 1000 and 250 micron meshes the microcapsules obtained; and selecting the fraction comprised between both meshes. The pharmaceutical composition can be an oral composition, tablets, chewable tablets, or a powder for suspension in water.

公开(公告)号：US20120294941A1

公开(公告)日：2012-11-22

申请号：US13576606

申请日：2010-02-01

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K31/365 ,  A61K9/44 ,  A61P3/04

CPC分类号： A61K9/145 ,  A61K9/0095 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/282 ,  A61K9/286 ,  A61K9/5084 ,  A61K31/365

摘要： Pharmaceutical compositions with anti-obesity activity that act peripherally are provided, which comprise a premixture made up of pure orlistat as the active ingredient and other components that afford the premixture stability and suitable physical properties for simply preparing compositions for oral use with convenient dosage flexibility; and optionally necessary thickening, flavouring and colouring agents. A method for preparing said compositions is also provided. The orlistat content in the premixture is less than 20% of the total weight of the mass, preferably between 12 and 17%.The pharmaceutical composition can be formulated indistinctively from the premixture both as grooved tablets and powder for suspension.

摘要翻译： 提供了具有外周作用的具有抗肥胖活性的药物组合物，其包含由纯奥利司他作为活性成分制成的预混合物和提供预混合物稳定性和合适的物理性质的简单制备用于口服使用的组合物的方便剂量灵活性的预混剂; 和任选需要的增稠剂，调味剂和着色剂。 还提供了制备所述组合物的方法。 预混物中的奥利司他含量小于质量总重量的20％，优选在12至17％之间。 药物组合物可以从预混合物中明显地与凹槽片剂和用于悬浮的粉末混合配制。

公开(公告)号：US07968118B2

公开(公告)日：2011-06-28

申请号：US11810453

申请日：2007-06-05

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K31/4439 ,  A61P1/04

CPC分类号： A61K9/0095 ,  A61K9/16 ,  A61K31/4439 ,  A61K33/00

摘要： An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the composition includes sodium alginate; an anti-acid soluble agent or a combination of anti-acids; an inhibitor of proton pump; diluent and sweetening agents, wherein a) at least 30% of sodium alginate present in the formulation along with the total of the inhibitor of proton pump are homogeneously distributed over the surface of the total soluble anti-acid agent of the combination of anti-acids of the composition; and b) the rest, about 70%, of sodium alginate present in the formulation contains a percentage of humidity of less than 2%.

摘要翻译： 一种抗酸药物组合物，用于通过粉末形式的粘膜保护活性快速和长时间地中和胃酸，通过在水中分散以制备用于口服的药物溶液或悬浮液，其特征在于该组合物包括藻酸钠; 抗酸可溶剂或抗酸组合; 质子泵抑制剂; 稀释剂和甜味剂，其中a）制剂中存在的至少30％的藻酸钠与质子泵抑制剂的总量一起均匀分布在抗酸组合的总可溶性抗酸剂的表面上 的组成; 和b）制剂中存在的海藻酸钠的其余约70％含有小于2％的湿度百分比。

公开(公告)号：US20070281015A1

公开(公告)日：2007-12-06

申请号：US11810453

申请日：2007-06-05

申请人： Mario Atilio Los

发明人： Mario Atilio Los

IPC分类号： A61K31/4439 ,  A61K9/46 ,  A61K33/00 ,  A61K33/06 ,  A61K33/10

CPC分类号： A61K9/0095 ,  A61K9/16 ,  A61K31/4439 ,  A61K33/00

摘要： An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the composition includes sodium alginate; an anti-acid soluble agent or a combination of anti-acids; an inhibitor of proton pump; diluent and sweetening agents, wherein a) at least 30% of sodium alginate present in the formulation along with the total of the inhibitor of proton pump are homogeneously distributed over the surface of the total soluble anti-acid agent or of the combination of anti-acids of the composition; and b) the rest, about 70%, of sodium alginate present in the formulation contains a percentage of humidity of less than 2%.

摘要翻译： 一种抗酸药物组合物，用于通过粉末形式的粘膜保护活性快速和长时间地中和胃酸，通过在水中分散以制备用于口服的药物溶液或悬浮液，其特征在于该组合物包括藻酸钠; 抗酸可溶剂或抗酸组合; 质子泵抑制剂; 稀释剂和甜味剂，其中a）制剂中存在的至少30％的海藻酸钠以及质子泵抑制剂的总量均匀地分布在总可溶性抗酸剂的表面或抗 - 组成的酸; 和b）制剂中存在的海藻酸钠的其余约70％含有小于2％的湿度百分比。