-
公开(公告)号:US20060234255A1
公开(公告)日:2006-10-19
申请号:US11340031
申请日:2006-01-26
申请人: Carol Pena , Li Li , Steven Spaderna , William LaRochelle , Kerry Quinn-Senger , Mario Leite
发明人: Carol Pena , Li Li , Steven Spaderna , William LaRochelle , Kerry Quinn-Senger , Mario Leite
CPC分类号: C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C12N9/00 , C12N9/48
摘要: The present invention provides novel isolated polynucleotides and small molecule target proteins encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target protein or any derivative, variant, mutant or fragment of that protein, polynucleotide or antibody are disclosed, as are methods in which the small molecule target protein, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译: 本发明提供了由多核苷酸编码的新型分离的多核苷酸和小分子靶蛋白。 公开了免疫特异性结合该蛋白质,多核苷酸或抗体的新型小分子靶蛋白或任何衍生物,变体,突变体或片段的抗体,其中小分子靶蛋白,多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地,本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断,治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗,诊断和研究方法。