公开(公告)号：US06139839A

公开(公告)日：2000-10-31

申请号：US158565

申请日：1998-09-22

申请人： William D. Odell ,  Jeanine T. Griffin ,  Sanjeev Grover ,  Omar Caticha ,  Douglas T. Carrell ,  Marion L. Woods, II

发明人： William D. Odell ,  Jeanine T. Griffin ,  Sanjeev Grover ,  Omar Caticha ,  Douglas T. Carrell ,  Marion L. Woods, II

IPC分类号： A61K38/00 ,  A61P5/02 ,  A61P31/04 ,  C07K16/26 ,  A61K39/395 ,  A61K39/00 ,  C07K16/00

CPC分类号： C07K16/26 ,  A61K2039/505 ,  A61K38/00

摘要： A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by administering to the warm-blooded animal an effective amount of an antibody capable of inhibiting the activity of the protein, the chorionic gonadotropin-like growth-regulating protein itself such that the animal develops a neutralizing immune response, or peptides that block the receptors of the chorionic gonadotropin-like growth-regulating protein in the infectious microorganism. Candida albicans is one such microorganism that can be controlled by delivering an antibody against the growth-regulating protein, CaCGLP. Mycobacteria can also be controlled by this method. A method of inhibiting transition of Candida albicans blastospores in vitro by contacting the blastospores with an antibody against CaCGLP is also disclosed. A method of inhibiting growth of mycobacteria in vitro comprises contacting the mycobacteria with an antibody against an endogenous chorionic gonadotropin-like growth-regulating protein. In vitro growth of microorganisms can also be stimulated by contacting the microorganism with a chorionic gonadotropin-like growth-regulating protein.

摘要翻译： 在温血动物中，控制表达绒毛膜促性腺激素样生长调节蛋白的感染性微生物的方法包括通过向温血动物施用有效量的能抑制绒毛膜促性腺激素生长调节蛋白的抗体来调节蛋白质的活性 蛋白质的活性，绒毛膜促性腺激素样生长调节蛋白本身使得动物产生中和免疫应答，或阻断感染性微生物中绒毛膜促性腺激素样生长调节蛋白的受体的肽。 白色念珠菌是一种这样的微生物，其可以通过递送针对生长调节蛋白CaCGLP的抗体来控制。 分枝杆菌也可以通过这种方法进行控制。 还公开了通过使胚泡与抗CaCGLP的抗体接触来抑制白色念珠菌胚轴的转化的方法。 一种在体外抑制分枝杆菌生长的方法包括使分枝杆菌与抗内源性绒毛膜促性腺激素样生长调节蛋白的抗体接触。 微生物的体外生长也可以通过使微生物与绒毛膜促性腺激素样生长调节蛋白接触来刺激。