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公开(公告)号：US20070088897A1
公开(公告)日：2007-04-19
申请号：US11581145
申请日：2006-10-13
IPC分类号： G06F12/08
CPC分类号： G06F17/30241 , G01C21/343 , G01C21/3676 , G09B29/007 , G09B29/106
摘要： Method and computer program product for presenting a set of address locations in a browser window of a user device via the Internet are disclosed. The method includes receiving a set of address locations in a given order, presenting the set of address locations as a list of directions, and presenting the set of address locations graphically on a map, where the map includes a route connecting the set of address locations according to the given order and a marker for each of the address locations. The method further includes creating a new order of the set of address locations from the given order by dragging an address location from the map to a different position in the list of directions, updating the list of directions according to the new order of the set of address locations, and updating the map according to the new order of the set of address locations.
摘要翻译： 公开了用于经由因特网在用户设备的浏览器窗口中呈现一组地址位置的方法和计算机程序产品。 该方法包括以给定的顺序接收一组地址位置，将一组地址位置呈现为方向列表，并以地图形式在地图上呈现一组地址位置，其中地图包括连接该组地址位置的路线 根据给定的顺序和每个地址位置的标记。 该方法还包括通过将地址位置从地图拖动到方向列表中的不同位置来创建来自给定顺序的一组地址位置的新顺序，根据该组的新顺序更新方向列表 地址位置，并根据地址位置集合的新顺序更新地图。
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公开(公告)号：US07829736B2
公开(公告)日：2010-11-09
申请号：US12061124
申请日：2008-04-02
IPC分类号： C07F9/02
CPC分类号： C07F9/657181 , C07C237/22 , C07F9/3895 , Y02P20/127
摘要： Method of performing condensation reactions, acylations or of preparing heterocycles comprising forming cyclic phosphonic anhydride of the formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.
摘要翻译： 使式（I）的膦酸衍生物与乙酸酐在30至150℃之间的温度范围内反应，同时分离出式（III）的环状膦酸酐，进行缩合反应，酰化或制备杂环的方法， 乙酸酐的混合物，b）然后反应性地蒸馏步骤a）中获得的式（II）的低聚膦酸酐，并将其转化为相应的式（III）的环状三聚膦酸酐， ，其中n表示0至300之间的数字，而R表示烯丙基，芳基或开链，环状或支链C1至C8烷基，芳氧基，烯丙氧基或包含开链，环状或支链C1至C8的烷氧基 烷基。 优选在步骤b）中形成的环状三聚膦酸酐立即溶解在相对于其表现出惰性行为的有机溶剂中。
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公开(公告)号：US20080183009A1
公开(公告)日：2008-07-31
申请号：US12061124
申请日：2008-04-02
IPC分类号： C07F9/38
CPC分类号： C07F9/657181 , C07C237/22 , C07F9/3895 , Y02P20/127
摘要： Method of performing condensation reactions, acylations or of preparing heterocycles comprising forming cyclic phosphonic anhydride of the formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.
摘要翻译： 使式（I）的膦酸衍生物与乙酸酐在30至150℃之间的温度范围内反应，同时分离出式（III）的环状膦酸酐，进行缩合反应，酰化或制备杂环的方法， 乙酸酐的混合物，b）然后反应性地蒸馏步骤a）中获得的式（II）的低聚膦酸酐，并将其转化为相应的式（III）的环状三聚膦酸酐， ，其中n表示0至300之间的数字，而R表示烯丙基，芳基或开链，环状或支链C1至C8烷基，芳氧基，烯丙氧基或包含开链，环状或支链C1至C8的烷氧基 烷基。 优选在步骤b）中形成的环状三聚膦酸酐立即溶解在相对于其表现出惰性行为的有机溶剂中。
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公开(公告)号：US07473794B2
公开(公告)日：2009-01-06
申请号：US10565470
申请日：2004-07-08
IPC分类号： C07F9/02
CPC分类号： C07F9/657181 , C07C237/22 , C07F9/3895 , Y02P20/127
摘要： Disclosed is a method for producing cyclic phosphonic acid anhydrides of formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.
摘要翻译： 公开了通过以下方式制备式（III）的环状膦酸酐的方法：a）使式（I）的膦酸衍生物与乙酸酐在30至150℃之间的温度下反应，同时分离出乙酸和乙酸的混合物 酸酐，b）然后反应性地蒸馏步骤a）中获得的式（II）的低聚膦酸酐，并将其转化为相应的式（III）的环状三聚膦酸酐，其中n表示 0和300，而R表示烯丙基，芳基或开链，环状或支链C1至C8烷基，芳氧基，烯丙氧基或包含开链，环状或支链C1至C8烷基的烷氧基。 优选在步骤b）中形成的环状三聚膦酸酐立即溶解在相对于其表现出惰性行为的有机溶剂中。
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公开(公告)号：US20070156332A1
公开(公告)日：2007-07-05
申请号：US11580776
申请日：2006-10-13
IPC分类号： G01C21/32
CPC分类号： G06F17/30241 , G01C21/343 , G01C21/3676 , G09B29/007 , G09B29/106
摘要： Method and computer program product for navigating a map in a browser window of a user device via the Internet are disclosed. The method includes providing a first map for showing geographic context of a general area, providing a second map for showing geographic context of a portion of the general area, superimposing the second map onto the first map, wherein the second map is represented by a highlighted area in the first map, and navigating the first map using the highlighted area. The method further includes displaying points of interest inside the highlighted area of the first map and in the second map for assisting a user in navigating to the points of interest, and displaying additional points of interest outside the shaded area of the first map for assisting a user in navigating to the additional points of interest.
摘要翻译： 公开了用于通过因特网在用户设备的浏览器窗口中导航地图的方法和计算机程序产品。 该方法包括提供用于显示一般区域的地理上下文的第一地图，提供用于显示一般区域的一部分的地理上下文的第二地图，将第二地图叠加到第一地图上，其中第二地图由高亮显示 区域，并使用突出显示的区域导航第一个地图。 该方法还包括在第一地图的突出显示的区域内和第二地图中显示兴趣点，以帮助用户导航到兴趣点，并且在第一地图的阴影区域外显示额外的兴趣点以辅助 用户导航到其他兴趣点。
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公开(公告)号：US20060264654A1
公开(公告)日：2006-11-23
申请号：US10565470
申请日：2004-07-08
申请人： Mark Wehner , Bettina Kirschbaum , Lothar Deutscher , Hans Wagner , Harald Hossl
发明人： Mark Wehner , Bettina Kirschbaum , Lothar Deutscher , Hans Wagner , Harald Hossl
CPC分类号： C07F9/657181 , C07C237/22 , C07F9/3895 , Y02P20/127
摘要： Disclosed is a method for producing cyclic phosphonic acid anhydrides of formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.
摘要翻译： 公开了通过以下方式制备式（III）的环状膦酸酐的方法：a）使式（I）的膦酸衍生物与乙酸酐在30至150℃之间的温度下反应，同时分离出乙酸和乙酸的混合物 酸酐，b）然后反应性地蒸馏步骤a）中获得的式（II）的低聚膦酸酐，并将其转化为相应的式（III）的环状三聚膦酸酐，其中n表示 0和300，而R代表烯丙基，芳基或开链，环状或支链C 1至C 8烷基，芳氧基，烯丙氧基或烷氧基， 链，环状或支链C 1至C 8烷基。 优选在步骤b）中形成的环状三聚膦酸酐立即溶解在相对于其表现出惰性行为的有机溶剂中。
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7.发明申请Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur 审中-公开用于治疗，诊断和预防异常蛋白质结构发生的疾病的活性物质公开(公告)号：US20050239808A1
公开(公告)日：2005-10-27
申请号：US10514015
申请日：2003-05-09
申请人： Thomas Schrader , Detlev Riesner , Petra Rzepecki , Luitgard Nagel-Steger , Mark Wehner , Christian Kirsten , Oliver Molt , Reza Zadmard , Katja Aschermann
发明人： Thomas Schrader , Detlev Riesner , Petra Rzepecki , Luitgard Nagel-Steger , Mark Wehner , Christian Kirsten , Oliver Molt , Reza Zadmard , Katja Aschermann
IPC分类号： A61P25/28 , C07D231/40 , C07D401/14 , A61K31/522 , A61K31/416 , A61K31/4196 , A61K31/4709 , C07D473/02 , C07D43/02
CPC分类号： C07D231/40 , C07D401/14
摘要： The invention on hand refers to diseases associated with abnormal protein structures, including Alzheimer's disease, Creutzfeldt-Jakob's disease, BSE and other prion-associated diseases. It is the task of the invention on hand to provide new active agents preventing the formation of amyloid plaques and to dissolve existing plaques, such agents being convenient for therapy, diagnosis and prophylaxis of diseases that are associated with abnormal protein structures. This task is performed in terms of the current invention by heterocyclic or aromatic agents with a rigid structure and a donor-acceptor-donor pattern (DAD), the latter being formed by donors and acceptors of hydrogen bridge linkages which comply with the β-sheet structure of the peptide or protein and thus fit as binding partners. The heterocyclic or aromatic agents are available at least as dimers. They recognise peptides and proteins with a β-sheet structure, form stable complexes with them and inhibit their aggregation to β-amyloid plaques. Furthermore, the new active agents are able to dissolve β-amyloid plaques that already exist. Another task of the current invention is to provide methods for the synthesis of said heterocyclic or aromatic compounds.
摘要翻译： 手头的发明是指与异常蛋白质结构相关的疾病，包括阿尔茨海默病，克雅氏病，疯牛病和其他朊病毒相关疾病。 本发明的任务是提供防止淀粉样蛋白斑块形成和溶解现有斑块的新的活性剂，所述药剂便于治疗，诊断和预防与异常蛋白质结构相关的疾病。 根据本发明，通过具有刚性结构和供体 - 受体 - 给体模式（DAD）的杂环或芳族化合物来执行该任务，后者由供体和符合β-折叠板的氢桥连接体的受体形成 肽或蛋白质的结构，因此适合作为结合配偶体。 杂环或芳族试剂至少可以作为二聚体获得。 它们识别具有β-折叠结构的肽和蛋白质，与它们形成稳定的复合物并抑制它们与β-淀粉样蛋白斑的聚集。 此外，新的活性剂能够溶解已经存在的β-淀粉样斑块。 本发明的另一个任务是提供合成所述杂环或芳族化合物的方法。
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公开(公告)号：US5711545A
公开(公告)日：1998-01-27
申请号：US656623
申请日：1996-05-31
申请人： Mark Wehner
发明人： Mark Wehner
IPC分类号： B60R21/205 , B60R21/2165 , B60R21/26 , B60R21/261 , B60R21/16
CPC分类号： B60R21/261 , B60R21/205 , B60R21/2165
摘要： An air bag system for use as a vehicle safety restraint, and a method for installing an air bag in a vehicle. The system comprises a folded air bag, means for securing the air bag to an instrument panel armature of the vehicle (e.g. by studs), a gas generator for inflating the air bag, a flexible air bag cover, a layer of foam preferably bonded to the cover, and layer of skin preferably bonded to the foam. The skin is of a material and finish consistent with the decorative finish to the vehicle and has a line of weakness adapted to split when subjected to a predetermined pressure such as that generated by the air bag inflating, to release the inflating air bag through the cover and the foam and skin layers. Preferably the line of weakness is arranged to perpendicularly intersect the direction of gas flow from the inflator so that release of the gas applies a point pressure on the line of weakness causing the skin to effectively zipper open and release the air bag. This system obviates the need for an expensive air bag deployment door and is more aesthetically pleasing to the vehicle owner since unsightly visible tear seams and door edges are eliminated.
摘要翻译： 一种用作车辆安全限制的气囊系统，以及一种在汽车中安装气囊的方法。 该系统包括折叠的气囊，用于将气囊固定到车辆的仪表板电枢（例如通过螺栓）的装置，用于使气囊充气的气体发生器，柔性气囊罩，优选地粘合到 覆盖物和优选粘合到泡沫上的皮肤层。 皮肤是材料，并且与车辆的装饰性完成一致，并且具有适合于在受到气囊膨胀产生的预定压力时分裂的弱线，以通过盖子释放充气气囊 和泡沫和皮肤层。 优选地，弱线布置成与来自充气机的气流的方向垂直相交，使得气体的释放对弱线施加点压力，导致皮肤有效地拉开开口并释放气囊。 该系统消除了昂贵的气囊展开门的需要，并且对于车主来说更美观，因为消除了难看的可见撕裂接缝和门边缘。
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