公开(公告)号：US08569451B2

公开(公告)日：2013-10-29

申请号：US13263954

申请日：2010-04-09

申请人： Anthony Rees ,  Börje Sellergren ,  Ecevit Yilmaz ,  Thomas Schrader

发明人： Anthony Rees ,  Börje Sellergren ,  Ecevit Yilmaz ,  Thomas Schrader

IPC分类号： C07K17/00

CPC分类号： C07K17/02 ,  B01D15/3809 ,  B01D15/3852 ,  B01J20/26 ,  B01J20/268 ,  C07K16/065 ,  C07K17/14

摘要： The present application relates to an affinity material useful in antibody purification.

摘要翻译： 本申请涉及用于抗体纯化的亲和材料。

公开(公告)号：US20120270795A1

公开(公告)日：2012-10-25

申请号：US13504325

申请日：2010-01-26

申请人： Thomas Schrader ,  Katrin Hochdörffer ,  Julia März-Berberich ,  Luitgard Nagel-Steger ,  Gal Bitan ,  Sharmistha Sinha

发明人： Thomas Schrader ,  Katrin Hochdörffer ,  Julia März-Berberich ,  Luitgard Nagel-Steger ,  Gal Bitan ,  Sharmistha Sinha

IPC分类号： A61K38/10 ,  A61P25/28 ,  A61K38/08 ,  A61K38/07 ,  A61P25/16 ,  A61K38/05 ,  A61K31/4155 ,  C07K5/02 ,  C07K7/02 ,  C07D403/14 ,  A61P25/00 ,  A61K38/06

CPC分类号： C07D231/38 ,  A61K38/00

摘要： The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

摘要翻译： 本发明涉及蛋白质错误折叠疾病的领域，因此涉及与蛋白质和/或肽的异常或致病性三维折叠相关或由其引起的或与蛋白质和/或肽的致病性构象变化相关的疾病， 如阿尔茨海默病。 特别地，本发明提供了新颖的三聚吡唑化合物，其对上述蛋白质错误折叠疾病具有治疗效果，并且是指其用于治疗这种蛋白质错折叠疾病，特别是神经变性疾病以及药物或药物组合物的用途 包括这些化合物。

公开(公告)号：US20120108548A1

公开(公告)日：2012-05-03

申请号：US13203962

申请日：2010-03-05

申请人： Gal Bitan ,  Akila Shanmugam ,  Aleksey Lomakin ,  Thomas Schrader ,  Frank Gerrit Klarner ,  Peter Talbiersky ,  Jolanta Polkowska ,  Frank Bastkowski ,  Sharmistha Sinha ,  Sally Frautschy

发明人： Gal Bitan ,  Akila Shanmugam ,  Aleksey Lomakin ,  Thomas Schrader ,  Frank Gerrit Klarner ,  Peter Talbiersky ,  Jolanta Polkowska ,  Frank Bastkowski ,  Sharmistha Sinha ,  Sally Frautschy

IPC分类号： A61K31/6615 ,  C07K14/47 ,  A61P25/28 ,  A61P25/00 ,  A61P3/10 ,  A61P25/16 ,  A61P25/14 ,  A61P21/00 ,  A61P25/20 ,  A61P43/00 ,  A61P13/12 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  C07F9/40 ,  A61K31/663 ,  C07F9/12

CPC分类号： C07F9/12 ,  A61K31/661 ,  A61K31/663 ,  A61K49/0052 ,  C07F9/4084

摘要： This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.

摘要翻译： 本发明提供抑制淀粉样蛋白聚集的新型组合物。 在各种实施方案中，组合物包含结合赖氨酸和/或精氨酸并由此抑制淀粉样蛋白形成蛋白质聚集的分子镊子。

公开(公告)号：US20120095165A1

公开(公告)日：2012-04-19

申请号：US13263954

申请日：2010-04-09

申请人： Anthony Rees ,  Börje Sellergren ,  Ecevit Yilmaz ,  Thomas Schrader

发明人： Anthony Rees ,  Börje Sellergren ,  Ecevit Yilmaz ,  Thomas Schrader

IPC分类号： C08G63/91 ,  C07K16/00

CPC分类号： C07K17/02 ,  B01D15/3809 ,  B01D15/3852 ,  B01J20/26 ,  B01J20/268 ,  C07K16/065 ,  C07K17/14

摘要： The present application relates to an affinity material useful in antibody purification.

摘要翻译： 本申请涉及用于抗体纯化的亲和材料。

公开(公告)号：US07833612B2

公开(公告)日：2010-11-16

申请号：US10936708

申请日：2004-09-09

申请人： Albrecht Uhlig ,  Michael Redecker ,  Marcus Schaedig ,  Thomas Schrader ,  Werner Humbs

发明人： Albrecht Uhlig ,  Michael Redecker ,  Marcus Schaedig ,  Thomas Schrader ,  Werner Humbs

IPC分类号： B32B7/14 ,  B32B7/02 ,  G09G3/30

CPC分类号： H01L51/0005 ,  B41M5/506 ,  B41M5/52 ,  Y10S428/917 ,  Y10T428/24851 ,  Y10T428/24942

摘要： A substrate for inkjet printing, which includes a photoresist layer structure on a base substrate, and a method of manufacturing the same are provided. The substrate, which has high surface tension variation and slight thickness variation, may be manufactured at a low cost. The substrate includes a discontinuous organic layer structure made of a fluorinated hydrocarbon or a polysiloxane on the photoresist layer structure.

摘要翻译： 提供了一种用于喷墨印刷的基板，其包括在基底基板上的光致抗蚀剂层结构及其制造方法。 可以以低成本制造具有高表面张力变化和轻微厚度变化的基材。 基板包括在光致抗蚀剂层结构上由氟化烃或聚硅氧烷制成的不连续的有机层结构。

公开(公告)号：US07737631B2

公开(公告)日：2010-06-15

申请号：US11419258

申请日：2006-05-19

申请人： Albrecht Uhlig ,  Kerstin Nolte ,  Thomas Schrader

发明人： Albrecht Uhlig ,  Kerstin Nolte ,  Thomas Schrader

IPC分类号： H01J1/62 ,  H01J63/04

CPC分类号： H01L51/0005 ,  H01L27/3283

摘要： A flat panel display and a method of manufacturing the same, which allows the formation of an organic film by inkjet printing while avoiding overflow of ink into adjacent areas, thus increasing the uniformity of thickness of the organic film and decreasing manufacturing costs. The flat panel display includes a substrate, a first electrode layer formed on the substrate, ink with material for a light emission layer formed on an active area of the first electrode layer, a repellant area formed of organic material located around the active area, and a border area also formed of organic material located between the active area and the repellant area. A surface energy of the border area is higher than a surface energy of the repellant area.

摘要翻译： 平板显示器及其制造方法，其允许通过喷墨印刷形成有机膜，同时避免墨水溢出到相邻区域中，从而增加有机膜的厚度均匀性并降低制造成本。 平板显示器包括基板，形成在基板上的第一电极层，形成在第一电极层的有效区域上的用于发光层的材料的墨水，由有源区域周围的有机材料形成的排斥区域，以及 边界区也由有机材料形成，位于有效区域和驱避区域之间。 边界区域的表面能高于排斥区域的表面能。

公开(公告)号：US20090233344A1

公开(公告)日：2009-09-17

申请号：US12403697

申请日：2009-03-13

申请人： MANFRED KURFURST ,  Christian Ramsch ,  Thomas Schrader ,  Thomas Moest

发明人： MANFRED KURFURST ,  Christian Ramsch ,  Thomas Schrader ,  Thomas Moest

IPC分类号： C12N9/94

CPC分类号： C12N9/94 ,  A61L2/0023

摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.

摘要翻译： 本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。 与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性降低了大于1log10的因子，以及根据该方法制备的胰酶 及其用于生产药物或营养补充剂的用途。

公开(公告)号：US07553207B2

公开(公告)日：2009-06-30

申请号：US11155562

申请日：2005-06-20

申请人： Albrecht Uhlig ,  Kerstin Nolte ,  Thomas Schrader

发明人： Albrecht Uhlig ,  Kerstin Nolte ,  Thomas Schrader

IPC分类号： H01L29/04 ,  H01L31/20 ,  H01L31/0376 ,  H01L27/01

CPC分类号： H01L51/56 ,  H01L2251/562

摘要： An organic light-emitting diode (OLED) with an increased service life and a method of manufacturing the same are provided. The OLED is subjected to electromagnetic radiation with a spectrum that at least partially overlaps the absorption spectrum of an organic material layer of the OLED. As a result, the OLED has a longer service life, reduced decay in its initial brightness, and more saturated color than a conventional OLED.

摘要翻译： 提供了具有更长使用寿命的有机发光二极管（OLED）及其制造方法。 对OLED进行电磁辐射，其光谱至少部分地与OLED的有机材料层的吸收光谱重叠。 结果，OLED比常规OLED具有更长的使用寿命，降低其初始亮度衰减和更饱和的颜色。

公开(公告)号：US20070073062A1

公开(公告)日：2007-03-29

申请号：US11601184

申请日：2006-11-17

申请人： P. Boatman ,  Thomas Schrader ,  Graeme Semple ,  Philip Skinner ,  Jae-Kyu Jung

发明人： P. Boatman ,  Thomas Schrader ,  Graeme Semple ,  Philip Skinner ,  Jae-Kyu Jung

IPC分类号： C07D231/54 ,  C07D403/02

CPC分类号： C07D403/04 ,  C07D209/80 ,  C07D209/88 ,  C07D231/54 ,  C07D265/36 ,  C07D471/04 ,  C07D471/14

摘要： The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

公开(公告)号：US20060273716A1

公开(公告)日：2006-12-07

申请号：US11419258

申请日：2006-05-19

申请人： Albrecht UHLIG ,  Kerstin NOLTE ,  Thomas SCHRADER

发明人： Albrecht UHLIG ,  Kerstin NOLTE ,  Thomas SCHRADER

IPC分类号： H05B33/00 ,  H01L51/50 ,  B05D5/06

CPC分类号： H01L51/0005 ,  H01L27/3283

摘要： A flat panel display and a method of manufacturing the same, which allows the formation of an organic film by inkjet printing while avoiding overflow of ink into adjacent areas, thus increasing the uniformity of thickness of the organic film and decreasing manufacturing costs. The flat panel display includes a substrate, a first electrode layer formed on the substrate, ink with material for a light emission layer formed on an active area of the first electrode layer, a repellant area formed of organic material located around the active area, and a border area also formed of organic material located between the active area and the repellant area. A surface energy of the border area is higher than a surface energy of the repellant area.

摘要翻译： 平板显示器及其制造方法，其允许通过喷墨印刷形成有机膜，同时避免墨水溢出到相邻区域中，从而增加有机膜的厚度均匀性并降低制造成本。 平板显示器包括基板，形成在基板上的第一电极层，形成在第一电极层的有效区域上的用于发光层的材料的墨水，由有源区域周围的有机材料形成的排斥区域，以及 边界区也由有机材料形成，位于有效区域和驱避区域之间。 边界区域的表面能高于排斥区域的表面能。