公开(公告)号：US06465496B1

公开(公告)日：2002-10-15

申请号：US09638106

申请日：2000-08-11

申请人： Judith Aronhime ,  David Leonov ,  Marko Kordova ,  Anchel Schwartz ,  Ben-Zion Dolitzky

发明人： Judith Aronhime ,  David Leonov ,  Marko Kordova ,  Anchel Schwartz ,  Ben-Zion Dolitzky

IPC分类号： A61K3144

CPC分类号： C07D213/74 ,  A61K31/64

摘要： The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol adduct. Methods for their preparation are also disclosed. The present invention also relates to processes for making torsemide modification I. Pharmaceutical compositions containing the new forms of torsemide and methods of using them are also disclosed.

摘要翻译： 本发明涉及形式为V，无定形托塞米特，杜邦2型溶剂加合物，杜邦2型乙醇加合物和杜邦2型异丙醇加合物的新型托马斯。 还公开了它们的制备方法。 本发明还涉及制备托塞米特改性的方法I.还公开了含有新形式的托塞米的药物组合物及其使用方法。