公开(公告)号：US10478482B2

公开(公告)日：2019-11-19

申请号：US16285353

申请日：2019-02-26

申请人： Markus Maeurer

发明人： Markus Maeurer

IPC分类号： A61K39/04 ,  A61K39/00 ,  C07K14/35 ,  C12Q1/48 ,  G01N33/569 ,  C12N15/117

摘要： The present invention provides new immunological compositions and vaccines comprising selected M. tuberculosis antigens and antigenic peptides as well as nucleic acids encoding said antigens for use in the prevention, prophylaxis and treatment of mycobacterial infection, especially tuberculosis. In particular the invention provides recombinant BCG based vaccines in which one or more of the selected M. tuberculosis antigens are over expressed. The invention further provides isolated peptides for use in methods for diagnosing, characterizing, or classifying mycobacterial infections.

公开(公告)号：US20190175715A1

公开(公告)日：2019-06-13

申请号：US16285353

申请日：2019-02-26

申请人： Markus Maeurer

发明人： Markus Maeurer

IPC分类号： A61K39/04 ,  C12Q1/48 ,  C12N15/117 ,  C07K14/35

CPC分类号： A61K39/04 ,  A61K2039/522 ,  C07K14/35 ,  C12N15/117 ,  C12Q1/48

摘要： The present invention provides new immunological compositions and vaccines comprising selected M. tuberculosis antigens and antigenic peptides as well as nucleic acids encoding said antigens for use in the prevention, prophylaxis and treatment of mycobacterial infection, especially tuberculosis. In particular the invention provides recombinant BCG based vaccines in which one or more of the selected M. tuberculosis antigens are over expressed. The invention further provides isolated peptides for use in methods for diagnosing, characterizing, or classifying mycobacterial infections.

公开(公告)号：US20140127251A1

公开(公告)日：2014-05-08

申请号：US14009931

申请日：2012-04-11

申请人： Markus Maeurer

发明人： Markus Maeurer

IPC分类号： A61K39/04 ,  C12Q1/48 ,  C12N15/117

CPC分类号： A61K39/04 ,  A61K2039/522 ,  C07K14/35 ,  C12N15/117 ,  C12Q1/48

摘要： The present invention provides new immunological compositions and vaccines comprising selected M. tuberculosis antigens and antigenic peptides as well as nucleic acids encoding said antigens for use in the prevention, prophylaxis and treatment of mycobacterial infection, especially tuberculosis. In particular the invention provides recombinant BCG based vaccines in which one or more of the selected M. tuberculosis antigens are over expressed. The invention further provides isolated peptides for use in methods for diagnosing, characterizing, or classifying mycobacterial infections.

摘要翻译： 本发明提供新的免疫组合物和疫苗，其包含选定的结核分枝杆菌抗原和抗原肽以及编码所述抗原的核酸，用于预防，预防和治疗分枝杆菌感染，特别是结核病。 特别地，本发明提供了重组基于BCG的疫苗，其中一种或多种选择的结核分枝杆菌抗原过表达。 本发明还提供用于诊断，表征或分类分枝杆菌感染的方法中的分离的肽。

公开(公告)号：US20180064798A1

公开(公告)日：2018-03-08

申请号：US15645760

申请日：2017-07-10

申请人： Markus Maeurer

发明人： Markus Maeurer

IPC分类号： A61K39/04 ,  C12Q1/48 ,  C12N15/117

CPC分类号： A61K39/04 ,  A61K2039/522 ,  C07K14/35 ,  C12N15/117 ,  C12Q1/48

摘要： The present invention provides new immunological compositions and vaccines comprising selected M. tuberculosis antigens and antigenic peptides as well as nucleic acids encoding said antigens for use in the prevention, prophylaxis and treatment of mycobacterial infection, especially tuberculosis. In particular the invention provides recombinant BCG based vaccines in which one or more of the selected M. tuberculosis antigens are over expressed. The invention further provides isolated peptides for use in methods for diagnosing, characterizing, or classifying mycobacterial infections.