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    Antibacterial amide compounds and pharmaceutical compositions containing the same
    3.
    发明授权
    Antibacterial amide compounds and pharmaceutical compositions containing the same 失效
    抗菌酰胺化合物和含有它的药物组合物

    公开(公告)号：US4315933A

    公开(公告)日：1982-02-16

    申请号：US190154

    申请日：1980-09-24

    申请人： Thomas F. Mich ,  Theodore H. Haskell ,  Marland P. Hutt, Jr.

    发明人： Thomas F. Mich ,  Theodore H. Haskell ,  Marland P. Hutt, Jr.

    IPC分类号： C07D239/36 ,  C07D499/00 ,  C07D499/64 ,  A61K31/505 ,  C07D499/70

    CPC分类号： C07D239/36 ,  C07D499/00

    摘要： Novel organic amide compounds which are N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-(acylaminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-(acylaminophenyl)-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

    摘要翻译： 通过（a）使适当的青霉素或酸式盐的游离氨基酸反应，得到具有广谱抗菌效用的N- [2-（酰基氨基苯基）-4-羟基-5-嘧啶基羰基]青霉素化合物的新型有机酰胺化合物或 甲硅烷基化的衍生物或其配合物与相应的N-2-（酰氨基苯基）-4-羟基-5-嘧啶羧酸的反应性衍生物或（b）使游离氨基酸6-氨基青霉烷酸或相关化合物或酸盐 或其甲硅烷基化衍生物与相应的DN- [2-（酰氨基苯基）-4-羟基-5-嘧啶基羰基] -2-取代的甘氨酸的反应性衍生物。 还公开了含有所述化合物的药物组合物和使用所述组合物治疗感染的方法。

    Antibacterial amide compounds and means for using the same
    7.
    发明授权
    Antibacterial amide compounds and means for using the same 失效
    抗菌酰胺化合物及其使用方法

    公开(公告)号：US4278681A

    公开(公告)日：1981-07-14

    申请号：US112657

    申请日：1980-01-31

    申请人： Theodore H. Haskell ,  Marland P. Hutt, Jr. ,  Ernest D. Nicolaides ,  Peter W. K. Woo ,  Gin G. Huang

    发明人： Theodore H. Haskell ,  Marland P. Hutt, Jr. ,  Ernest D. Nicolaides ,  Peter W. K. Woo ,  Gin G. Huang

    IPC分类号： C07D207/16 ,  C07D207/28 ,  C07D213/80 ,  C07D213/85 ,  C07D499/00 ,  C07D499/64 ,  C07F7/10 ,  A61K31/455 ,  C07D499/68

    CPC分类号： C07D213/80 ,  C07D207/16 ,  C07D207/28 ,  C07D213/85 ,  C07D499/00 ,  C07F7/10

    摘要： Novel organic amide compounds which are N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)-phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

    摘要翻译： 通过以下方法提供了具有广谱抗菌效用的N- [6 - [（酰氨基酰氨基或氨基酰氨基）苯基] -1,2-二氢-2-氧代烟碱基]青霉素化合物的新型有机酰胺化合物：（a）使游离氨基酸 适当的青霉素或其酸盐或甲硅烷基化衍生物或其配合物与相应的N-6 - [（酰氨基酰基氨基或氨基酰氨基） - 苯基] -1,2-二氢-2-氧代烟酸的反应性衍生物或（b） 氨基酸6-氨基青霉烷酸或相关化合物或其酸式盐或甲硅烷基化衍生物与相应的DN- [6 - [（酰氨基酰基氨基或氨酰基氨基）苯基] -1,2-二氢-2-氧代烟酰基] - 2-取代甘氨酸。 还公开了含有所述化合物的药物组合物和使用所述组合物治疗感染的方法。

    Novel antibacterial amide compounds and process means for producing the same
    8.
    发明授权
    Novel antibacterial amide compounds and process means for producing the same 失效
    新型抗菌酰胺化合物及其制备方法

    公开(公告)号：US4267180A

    公开(公告)日：1981-05-12

    申请号：US117318

    申请日：1980-01-31

    申请人： Theodore H. Haskell ,  Marland P. Hutt, Jr. ,  Ernest D. Nicolaides

    发明人： Theodore H. Haskell ,  Marland P. Hutt, Jr. ,  Ernest D. Nicolaides

    IPC分类号： C07D239/36 ,  C07D499/00 ,  C07D499/64 ,  C07D521/00 ,  A61K31/505 ,  C07D499/68

    CPC分类号： C07D239/36 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D499/00

    摘要： Novel organic amide compounds which are N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl] penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid of 6-aminopenicillamic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

    摘要翻译： 通过（a）使适当的青霉素的游离氨基酸反应，得到具有广谱抗菌效用的N- [2 - [（酰氨基酰氨基或氨酰氨基）苯基] -4-羟基-5-嘧啶基羰基]青霉素化合物的新型有机酰胺化合物 或其酸性盐或甲硅烷基化衍生物或其配合物与相应的N-2 - [（酰氨基酰基氨基或氨基酰基氨基）苯基] -4-羟基-5-嘧啶羧酸的反应性衍生物或（b）游离氨基酸6 - 氨基青霉胺酸或相关化合物或其酸式盐或甲硅烷基化衍生物与相应的DN- [2 - [（酰氨基酰基氨基或氨酰基氨基）苯基] -4-羟基-5-嘧啶基羰基] -2-取代的甘氨酸的反应性衍生物。 还公开了含有所述化合物的药物组合物和使用所述组合物治疗感染的方法。