公开(公告)号：US20070053891A1

公开(公告)日：2007-03-08

申请号：US11591717

申请日：2006-11-02

申请人： Amparo Cano Garcia ,  Ma Angela Nieto Toledano ,  Maria Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Fernandez de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Moreno

发明人： Amparo Cano Garcia ,  Ma Angela Nieto Toledano ,  Maria Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Fernandez de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Moreno

IPC分类号： A61K48/00 ,  A61K39/395 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/43504 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00

摘要： The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of tissue invasion and metastatic capacity.

公开(公告)号：US20070065450A1

公开(公告)日：2007-03-22

申请号：US11599664

申请日：2006-11-15

申请人： Amparo Cano Garcia ,  M. Angela Nieto Toledano ,  M. Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Blanco de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Moreno

发明人： Amparo Cano Garcia ,  M. Angela Nieto Toledano ,  M. Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Blanco de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Moreno

IPC分类号： G01N33/574 ,  C12Q1/00 ,  C12Q1/68 ,  A61K39/395 ,  A61K48/00

CPC分类号： C07K14/43504 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00

摘要： The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of tissue invasion and metastatic capacity.

公开(公告)号：US20070054307A1

公开(公告)日：2007-03-08

申请号：US11591825

申请日：2006-11-02

申请人： Amparo Cano Garcia ,  Ma Angela Nieto Toledano ,  Ma Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Fernandez de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Mareno

发明人： Amparo Cano Garcia ,  Ma Angela Nieto Toledano ,  Ma Isabel Rodrigo Castro ,  Annamaria Locascio ,  Marta Garcia del Barrio ,  Maria Jose Fernandez de Valderrama ,  Francisco Portillo Perez ,  Mirna Perez Mareno

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/43504 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/00

摘要： The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of tissue invasion and metastatic capacity.