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公开(公告)号：US07977337B2
公开(公告)日：2011-07-12
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/47 , A61K31/496
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US07452888B2
公开(公告)日：2008-11-18
申请号：US10509078
申请日：2003-03-25
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , C07D215/40
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.
摘要翻译： 公开了式（I）的新型喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS障碍中的用途。
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公开(公告)号：US20100305107A1
公开(公告)日：2010-12-02
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/551 , A61K31/4985 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/30
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US07799774B2
公开(公告)日：2010-09-21
申请号：US12541456
申请日：2009-08-14
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/47 , C07D215/40 , C07D471/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US20090036682A1
公开(公告)日：2009-02-05
申请号：US12205079
申请日：2008-09-05
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： C07D401/10
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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公开(公告)号：US08236947B2
公开(公告)日：2012-08-07
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/551 , C07D401/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US20090298841A1
公开(公告)日：2009-12-03
申请号：US12541456
申请日：2009-08-14
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4985 , C07D401/10 , C07D487/04 , A61K31/496 , A61P25/00 , A61P3/04
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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