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公开(公告)号：US08236947B2
公开(公告)日：2012-08-07
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/551 , C07D401/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US08101775B2
公开(公告)日：2012-01-24
申请号：US12520145
申请日：2007-12-19
申请人： Mahmood Ahmed , James Myatt , David Norton , Dean Andrew Rivers
发明人： Mahmood Ahmed , James Myatt , David Norton , Dean Andrew Rivers
IPC分类号： A61K31/443 , A61K31/405 , A61K31/4245 , C07D271/06 , C07D209/04 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to compounds of formula (I) wherein one of R5 and R6 is hydrogen or R2 and the other is (a) pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the S1P1 receptor.
摘要翻译： 本发明涉及式（I）化合物，其中R 5和R 6中的一个是氢或R 2，另一个是（a）含有它们的药物组合物及其在治疗通过S1P1受体介导的病症或病症中的用途。
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3.发明申请OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS 失效用作磷酸1-磷酸（S1P）激动剂的奥氮唑取代的吲哚衍生物公开(公告)号：US20100113528A1
公开(公告)日：2010-05-06
申请号：US12596488
申请日：2008-04-17
IPC分类号： A61K31/4439 , C07D271/06 , C07D413/04 , A61K31/4245 , A61P37/06 , A61P35/00 , A61P1/06
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides compounds of formula (I) or salts thereof: having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
摘要翻译： 本发明提供式（I）化合物或其盐：具有药理活性，其制备方法，含有它们的药物组合物及其用于治疗由S1P1受体介导的各种疾病的用途。
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公开(公告)号：US20090298841A1
公开(公告)日：2009-12-03
申请号：US12541456
申请日：2009-08-14
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4985 , C07D401/10 , C07D487/04 , A61K31/496 , A61P25/00 , A61P3/04
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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公开(公告)号：US07601837B2
公开(公告)日：2009-10-13
申请号：US12205079
申请日：2008-09-05
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , David R Witty
IPC分类号： C07D215/40
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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6.发明申请5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders 审中-公开5-磺基-1-哌啶基取代的吲哚衍生物作为治疗Cns病的5-Ht6受体拮抗剂公开(公告)号：US20080318933A1
公开(公告)日：2008-12-25
申请号：US11576070
申请日：2005-10-05
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Neil Derek Miller , Peter Henry Milner , Dean Andrew Rivers , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Neil Derek Miller , Peter Henry Milner , Dean Andrew Rivers , David R Witty
IPC分类号： A61K31/55 , C07D401/04 , A61K31/454 , A61P3/00 , A61P25/00 , C07D403/04 , A61K31/403
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to novel indole derivatives such as compounds of the formula (I): which possess antagonist potency at the 5-HT6 receptor and the use of such compounds or pharmaceutically acceptable salts or solvates thereof in the treatment of Alzheimer's disease and other CNS disorders.
摘要翻译： 本发明涉及新的吲哚衍生物，例如式（I）的化合物：其具有5-HT 6受体的拮抗剂效力，以及这些化合物或其药学上可接受的盐或溶剂化物在治疗阿尔茨海默病和其它CNS中的用途 疾病
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公开(公告)号：US20050090496A1
公开(公告)日：2005-04-28
申请号：US10503682
申请日：2003-02-04
申请人： Mahmood Ahmed , Steven Bromidge
发明人： Mahmood Ahmed , Steven Bromidge
IPC分类号： A61K31/40 , A61K31/496 , A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D471/04 , A61K31/519 , A61K31/503
CPC分类号： C07D471/04 , A61K31/40
摘要： The present invention relates to novel sulfonamide compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
摘要翻译： 本发明涉及具有药理学活性的新型磺酰胺化合物，其制备方法，含有它们的组合物及其在治疗CNS和其它疾病中的用途。
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8.发明授权Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists 失效恶二唑取代的吲唑衍生物，用作1-肌氨酸鞘磷脂（S1P）激动剂公开(公告)号：US08324254B2
公开(公告)日：2012-12-04
申请号：US12596488
申请日：2008-04-17
IPC分类号： A01N43/40 , A61K31/44 , C07D271/06 , C07D271/12 , C07D413/00 , C07D498/00 , C07D413/04 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides compounds of formula (I) or salts thereof: having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
摘要翻译： 本发明提供式（I）化合物或其盐：具有药理活性，其制备方法，含有它们的药物组合物及其用于治疗由S1P1受体介导的各种疾病的用途。
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公开(公告)号：US20110237792A1
公开(公告)日：2011-09-29
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： C07D403/10 , C07D401/10 , C07D487/04
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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公开(公告)号：US20100305107A1
公开(公告)日：2010-12-02
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/551 , A61K31/4985 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/30
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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