公开(公告)号：US20080261917A1

公开(公告)日：2008-10-23

申请号：US11574531

申请日：2005-08-26

申请人： Hendrika Maria Gerarda Willems ,  Per Kallblad ,  Ian Robert Hardcastle ,  Robert John Griffin ,  Bernard Thomas Golding ,  John Lunec ,  Martin E.M. Noble ,  David R. Newell ,  Alan H. Calvert

发明人： Hendrika Maria Gerarda Willems ,  Per Kallblad ,  Ian Robert Hardcastle ,  Robert John Griffin ,  Bernard Thomas Golding ,  John Lunec ,  Martin E.M. Noble ,  David R. Newell ,  Alan H. Calvert

IPC分类号： A61K31/695 ,  C07D209/44 ,  A61K31/4035 ,  C07D213/02 ,  C07D295/00 ,  A61P35/00 ,  A61K31/496 ,  A61K31/4439 ,  C07D233/54 ,  A61K31/4164

CPC分类号： C07D209/50 ,  C07D209/48 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12

摘要： A compound of formula or a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S; R1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R4-R7, is used to represent groups R4, R5, R6 and R7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF3, NH2, NO2, COOH, C=0.

摘要翻译： 式或其前药和/或其药学上可接受的盐的化合物，其中X为O，N或S; 取代或未取代的烷基，取代或未取代的烷基胺，烷氧基，取代或未经取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂芳烷基; R 1是氢，卤素，羟基， R 2是氢，卤素，羟基，取代或未取代的烷基，取代或未取代的羟基烷基取代或未取代的烷基胺，烷氧基，取代或未取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂烷基; 取代或未取代的烷基烷氧基，取代或未取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂烷基; 和R 4〜R 7，用于表示R 4，R 5，R 5， 6和7是H，OH，烷基，烷氧基，烷基胺，羟基烷基，卤素，CF 3，NH 2， NO 2，COOH，C = 0。