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公开(公告)号：US20100184965A1
公开(公告)日：2010-07-22
申请号：US12585886
申请日：2009-09-28
申请人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
发明人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1825 , A61K38/185 , A61K38/1866 , A61K38/27 , A61K38/29 , A61K47/42 , A61K47/61
摘要： The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.
摘要翻译： 本发明涉及由多糖和HBP组成的复合物，所述多糖由（1,6）和/或（1,4）和/或（1,3）和/或（1,2）的糖苷键组成 ）类型并用至少一种可成盐或盐化的色氨酸衍生物官能化。 本发明还涉及包含根据本发明的复合物和由（1,6）和/或（1,4）和/或（1,3）和/或（1,3）的糖苷键组成的多糖和/ 或（1,2）型，并用至少一种可成盐或盐化的色氨酸衍生物官能化，用于制备稳定HBP的药物制剂。
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2.发明申请Stable pharmaceutical composition comprising at least one monoclonal antibody and at least one amphiphilic polysaccharide comprising hydrophobic substituents 审中-公开稳定的药物组合物，其包含至少一种单克隆抗体和至少一种包含疏水取代基的两亲性多糖公开(公告)号：US20110014189A1
公开(公告)日：2011-01-20
申请号：US12654552
申请日：2009-12-23
申请人： Olivier Soula , Gerard Soula , Martin Gaudier , Remi Soula
发明人： Olivier Soula , Gerard Soula , Martin Gaudier , Remi Soula
IPC分类号： A61K39/395 , A61P17/00 , A61P35/00 , A61P11/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P1/00 , A61P3/00 , A61P5/00
CPC分类号： A61K39/39591 , A61K47/26 , A61K47/36 , C07K16/22 , Y02A50/394
摘要： A stable pharmaceutical composition with at least one monoclonal antibody and at least one amphiphilic polysaccharide chosen from the group of amphiphilic polysaccharides comprising carboxylate functional groups partly substituted with at least one hydrophobic substituent is disclosed.
摘要翻译： 公开了具有至少一种单克隆抗体和至少一种两亲性多糖的稳定药物组合物，其选自包含部分被至少一个疏水性取代基取代的羧酸官能团的两亲性多糖组。
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公开(公告)号：US08367640B2
公开(公告)日：2013-02-05
申请号：US12585886
申请日：2009-09-28
申请人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
发明人： Olivier Soula , Remi Soula , Martin Gaudier , Gerard Soula
IPC分类号： A01N43/04 , A01N61/00 , A61K31/715 , A61K31/00
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1825 , A61K38/185 , A61K38/1866 , A61K38/27 , A61K38/29 , A61K47/42 , A61K47/61
摘要： The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition comprising a complex according to the invention and to the use of a polysaccharide consisted of glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative, for the preparation of a pharmaceutical formulation of stable HBPs.
摘要翻译： 本发明涉及由多糖和HBP组成的复合物，所述多糖由（1,6）和/或（1,4）和/或（1,3）和/或（1,2）的糖苷键组成 ）类型并用至少一种可成盐或盐化的色氨酸衍生物官能化。 本发明还涉及包含根据本发明的复合物和由（1,6）和/或（1,4）和/或（1,3）和/或（1,3）的糖苷键组成的多糖和/ 或（1,2）型，并用至少一种可成盐或盐化的色氨酸衍生物官能化，用于制备稳定HBP的药物制剂。
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