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公开(公告)号:US20190192629A1
公开(公告)日:2019-06-27
申请号:US15777222
申请日:2016-11-18
申请人: Herantis Pharma Plc
发明人: Henri Huttunen , Mikko Airavaara , Mart Saarma
CPC分类号: A61K38/185 , A61K9/0043
摘要: The present invention is directed to a composition for intranasal administration comprising a CDNF polypeptide for use in the intranasal treatment of a central nervous system disease, such as Alzheimer's disease, Parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, dementia with Lewy bodies, mild cognitive impairment, Huntington's disease, traumatic brain injury and stroke. The present invention is also directed to a composition for intranasal administration comprising a MANF polypeptide for use in the intranasal treatment of a central nervous system disease.
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公开(公告)号:US20180333458A1
公开(公告)日:2018-11-22
申请号:US16047129
申请日:2018-07-27
发明人: Avinoam KADOURI , Avihay BAR-ILAN , Eldad MELAMED , Daniel OFFEN , Ofer SADAN , Merav BAHAT-STROMZA
CPC分类号: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
摘要: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
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公开(公告)号:US10080778B2
公开(公告)日:2018-09-25
申请号:US15297386
申请日:2016-10-19
发明人: Khalid Iqbal , Inge Grundke-Iqbal
CPC分类号: A61K38/185 , A61K38/00 , A61K38/07 , C07K5/10 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021
摘要: Five tetra peptides corresponding to different active regions of brain derived neurotrophic factor (BDNF) that are neurotrophic and can modulate BDNF signaling in a partial agonist/antagonist way. The peptides offer a therapeutic approach to neural pathologies where BDNF levels are dysregulated.
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公开(公告)号:US20180177790A1
公开(公告)日:2018-06-28
申请号:US15902491
申请日:2018-02-22
发明人: David R. Elmaleh
IPC分类号: A61K31/5415 , C07K16/18 , A61K31/075 , A61K31/55 , A61K31/713 , A61K38/18 , A61K39/00
CPC分类号: A61K31/5415 , A61K31/047 , A61K31/075 , A61K31/13 , A61K31/192 , A61K31/194 , A61K31/225 , A61K31/352 , A61K31/353 , A61K31/428 , A61K31/435 , A61K31/438 , A61K31/55 , A61K31/706 , A61K31/713 , A61K38/185 , A61K39/0005 , A61K45/06 , A61K48/00 , A61K51/0453 , C07K16/18 , A61K2300/00
摘要: The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
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公开(公告)号:US09968706B2
公开(公告)日:2018-05-15
申请号:US14603616
申请日:2015-01-23
发明人: Mark E. Van Dyke
CPC分类号: A61L27/26 , A61K38/185 , A61L27/227 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/32 , A61N1/0551 , Y10S524/916
摘要: A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
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公开(公告)号:US20180110833A1
公开(公告)日:2018-04-26
申请号:US15568450
申请日:2016-04-18
申请人: STAIDSON (BEIJING) BIOPHARMACEUTICALS CO., LTD. , BEIJING STAIDSON MEDICAL TECHNOLOGY CO., LTD.
发明人: Jianping TAN , Bingzhang WANG
CPC分类号: A61K38/185 , A61K9/08 , A61K9/19 , A61K38/18 , A61K47/14 , A61K47/183 , A61K47/26 , A61K47/36 , A61P25/00
摘要: The present invention discloses a nerve growth factor composition and an injection powder comprising a nerve growth factor, a stabilizer, a supporting agent, a pH buffer, water and optionally a surfactant. The stabilizer may be selected from arginine, glutamic acid, glycine and isoleucine. By using an amino acid instead of albumin as a stabilizer, the nerve growth factor composition and the injection powder can avoid the potential risk of viral or other unknown components carried in albumin, ensuring the stability of hNGF and rhNGF during preparation, transportation and storage processes, and allowing for increased safety and quality control.
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公开(公告)号:US20180055766A1
公开(公告)日:2018-03-01
申请号:US15805842
申请日:2017-11-07
申请人: Neurotech USA, Inc.
发明人: Cahil McGovern , Weng Tao , Konrad Kauper
IPC分类号: A61K9/00 , A61F9/00 , A61K38/21 , A61K38/20 , A61K38/18 , C12N5/00 , A61K47/34 , A61K35/30 , A61K38/19 , C12N5/079
CPC分类号: A61K9/0051 , A61F9/0017 , A61K9/4816 , A61K35/30 , A61K38/185 , A61K38/19 , A61K38/2066 , A61K38/212 , A61K38/215
摘要: Described herein are methods and devices for the long term treatment of ophthalmic disorders. Also disclosed are encapsulated cell therapy (ECT) devices that secrete a biologically active molecule and methods for using the same for the treatment of various kinds of ophthalmic disorders, including retinitis pigmentosa, geographic atrophy (dry age-related macular degeneration), glaucoma and/or macular telangiectasia.
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公开(公告)号:US09845344B2
公开(公告)日:2017-12-19
申请号:US10594192
申请日:2005-03-30
申请人: Mette Grønborg , Philip Kusk , Nikolaj Blom , Thomas Nordahl Petersen , Teit E. Johansen , Søren Brunak , Lars U. Wahlberg
发明人: Mette Grønborg , Philip Kusk , Nikolaj Blom , Thomas Nordahl Petersen , Teit E. Johansen , Søren Brunak , Lars U. Wahlberg
IPC分类号: A61K38/18 , C07K14/475 , A01K67/027 , A61K38/17 , A61K38/00
CPC分类号: C07K14/475 , A01K67/027 , A01K2207/05 , A01K2207/20 , A01K2227/105 , A01K2267/0356 , A61K38/00 , A61K38/17 , A61K38/185 , C12N2799/027
摘要: The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.
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公开(公告)号:US20170298110A1
公开(公告)日:2017-10-19
申请号:US15443712
申请日:2017-02-27
CPC分类号: C07K14/475 , A61K35/30 , A61K38/00 , A61K38/18 , A61K38/185 , G01N33/5058
摘要: In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a pharmaceutical composition that includes MANF and a pharmaceutically-acceptable excipient, methods for treatment of a neurodegenerative disease, methods for improving dopaminergic neuronal survival during or following cell transplantation, methods for production of neurons for transplantation, and methods for identifying compounds that modulate or mimic MANF's biological activity.
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公开(公告)号:US20170166926A1
公开(公告)日:2017-06-15
申请号:US15374596
申请日:2016-12-09
IPC分类号: C12N15/86 , C07K14/005 , C12N15/113 , A61K38/02 , C07K16/18 , A61K38/18 , A61K38/48 , A61K38/50 , A61K38/43 , A61K38/17 , A61K38/20 , C12N7/00 , A61K38/47
CPC分类号: C12N15/86 , A61K38/00 , A61K38/02 , A61K38/1709 , A61K38/185 , A61K38/2093 , A61K38/43 , A61K38/47 , A61K38/4813 , A61K38/50 , A61K48/00 , C07K14/005 , C07K16/18 , C07K2317/622 , C07K2319/00 , C12N7/00 , C12N15/113 , C12N15/1137 , C12N2310/122 , C12N2310/141 , C12N2320/32 , C12N2330/51 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171 , C12Y302/0102 , C12Y304/14009 , C12Y305/01015 , C12N2310/14 , C12N2310/531
摘要: Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.
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