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公开(公告)号:US20120115794A1
公开(公告)日:2012-05-10
申请号:US13378574
申请日:2010-06-11
CPC分类号: A61K38/08 , A61K38/177
摘要: The present invention relates to the use of peptide compounds for the prevention and/or treatment of ophthalmic diseases. In particular, the present invention relates to a peptide compound comprising an amino acid sequence displayed by amino acids 7 to 11 of SEQ ID NO: 2 (KEQWFGNRWHEGYR) or of SEQ ID NO: 1 (KEKWFENEWQGKNP), or a functionally active derivative thereof, or a pharmaceutically acceptable salt thereof, for use in the prevention and/or treatmend of an ophthalmic disease in an individual. While SEQ ID NO: 2 is a part of the human CD44v6, SEQ ID NO: 1 is a part of the rat CD44v6.
摘要翻译: 本发明涉及肽化合物在预防和/或治疗眼科疾病中的应用。 特别地,本发明涉及包含由SEQ ID NO:2(KEQWFGNRWHEGYR)或SEQ ID NO:1(KEKWFENEWQGKNP)的氨基酸7至11显示的氨基酸序列或其功能活性衍生物的肽化合物, 或其药学上可接受的盐,用于预防和/或治疗个体眼科疾病。 虽然SEQ ID NO:2是人CD44v6的一部分,但是SEQ ID NO:1是大鼠CD44v6的一部分。